Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ML1956 | ML1956 | Kenya | 2001 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S24H, V32I, I72V, E96D, L101I, T112V, T124A, T125A, K136Q, I182V, V201I, K215R, Q216N, L234I, D279DG | S283SG |
| >ML1956| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMAHDFNLPPVIAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQDTAYFILKLAGRWPVKVIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FVHNFKRKGGIGGYSAGERIIDIIATDIQTKELQRNITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDGCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, I15V, M36I, R41K, L63T, H69Q |
| >ML1956| codons 1-99 PQITLWQRPIVTVKVGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QITIEICGQKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, T39A, I135R, I142V, D177E, I178M, T200I, Q207E, R211K, K238R, V245K, D250E, A272P, K277R, L282C, L283I, V292I, I293V, P321Q, G335D, F346L, R356K, G359T, T377Q, S379C, K385R, K390R, E399D, A400T, E413ED, V435IM, L469I, H483N, L491S, A534S, A554S |
| >ML1956| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSRNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRIKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDRWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKCIRGTKALTEIVPLTEEAE LELAENREILKEPVHGVYYDQSKDLIAEIQKQGQDQWTYQIYQEPLKNLKTGKYAKMRTA HTNDVKQLTEAVQKIAQECIVIWGRTPKFRLPIQKETWDTWWTEYWQATWIPDWEFVNTP PLVKLWYQLEKEPIMGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSITDTTNQKTELQ AINLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Land, AM | Full-length HIV type 1 proviral sequencing of 10 highly exposed women from Nairobi, Kenya reveals a high proportion of intersubtype recombinants. | ARHR, 2008 |