Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4172 | CA10014 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC+SQV | 47 |
| 2 | 3TC+AZT+DDC | 13 |
| 3 | D4T+DDI | 8 |
| 4 | D4T+IDV | 30 |
| 5 | 3TC+D4T+RTV+SQV | 17 |
| 6 | 3TC+D4T+NFV+SQV | 13 |
| 7 | Unknown | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90LM | G73GS | L10I, I13V, K20IM, M36I, L63P, A71AV, I72V |
| >CA10014| codons 1-99 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVVSTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, M184MI, L210W | K219R | V35I, K43X, K122E, I202V, R211K, T215X, D218DE, D250E, S251D, A272P, K277R, Q278N, L283I, T286A, I293V, P294S |
| >CA9948| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEXEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVGSDLEIGQHRTKVEELRQHLWKWGFXTPERKHQKEPPFLWMGYELHPDKWT VQPIVLPEKEDWTVNDIQKLVGKLNWASQIYPGIKVRNLCKLIRGAKALTEVVSLTEEAE LEL |
References
| Author | Title | Citation |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: Clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |