Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA796 | CA10007 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | AZT+DDI | 266 |
| 3 | 3TC+D4T+SQV | 39 |
| 4 | D4T+DDC+NFV | 17 |
| 5 | 3TC+AZT+IDV+NVP | 17 |
| 6 | 3TC+AZT+IDV | 10 |
| 7 | 3TC+AZT+RTV+SQV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | F53L, G73S | L10I, L24LF, N37D, D60E, L63P, A71IV, V77I, I93L |
| >CA10007| codons 1-99 PQITLWQRPIVTIKIGGQLKEALFDTGADDTVLEEMDLPGRWKPKIIGGIGGLIKVRQYE QIPIEICGHKIISTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, M184V, T215F | K219W | K103KN, Y181C | V35T, V60I, I94L, K122E, I135T, V179I, H208Y, D218E, L228H, V245E, E248Q, A272P, A288S, V292I, I293V |
| >CA9945| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQDFWEVQLGLPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVGSDLEIGQHRTKIEELRQYLLRWGFFTPEWKHQKEPPFHWMGYELHPDKWT VQPIELPQKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEIVPLTEEAE LEL |
References
| Author | Title | Citation |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |