HIVDB
8.6
2018-07-03
PR
PI
RT
NRTI,NNRTI
IN
INSTI
1
Susceptible
S
2
Potential Low-Level Resistance
S
3
Low-Level Resistance
I
4
Intermediate Resistance
I
5
High-Level Resistance
R
NRTI
ABC,AZT,D4T,DDI,FTC,3TC,TDF
NNRTI
EFV,ETR,NVP,RPV
PI
ATV/r,DRV/r,FPV/r,IDV/r,LPV/r,NFV,SQV/r,TPV/r
INSTI
BIC,DTG,EVG,RAL
1, 10 TO 14 => 2, 15 TO 29 => 3, 30 TO 59 => 4, 60 TO INF => 5)]]>
5-fold reduced susceptibility to each of the INSTIs. $listMutsIn{118(NOT R)} is an unusual mutation at this position.]]>
1
5-fold reduced susceptibility to each of the INSTIs. Data are not available for BIC.]]>
1
1
1
1
1
1
1
1
1
100-fold. Alone, Y143C/R have minimal effects on EVG susceptibility. However, they are associated with intermediate to high-level reductions in EVG susceptibility (~10-fold) when they occur in combination with one or more accessory INSTI-resistance mutations. Y143 mutations do not reduce DTG or BIC susceptibility.]]>
1
100-fold. Alone, Y143C/R have minimal effects on EVG susceptibility. However, they are associated with ~10-fold reduced EVG susceptibility when they occur in combination with two or more accessory INSTI-resistance mutations. Y143 mutations do not reduce DTG or BIC susceptibility. $listMutsIn{143(NOT CRHKGSA)} is an unusual mutation at this position.]]>
1
100-fold. Y143H is a less-common mutation at this position that is likely a transitional mutation between the wildtype Y amino acid and the mutant R (which differs from the wildtype Y by two nucleotides).]]>
1
1
1
1
1
1
1
1
100-fold. Alone, Q148H/K/R have minimal effects on DTG and BIC susceptibility. In combination with G140S/A/C and/or E138K/A/T, they cause moderate to high level reductions in DTG and BIC susceptibility. $listMutsIn{148(NOT HKRN)} is an unusual mutation at this position.]]>
1
100-fold. Alone, Q148H/K/R have minimal effects on DTG and BIC susceptibility. In combination with G140S/A/C and/or E138K/A/T, they cause moderate to high level reductions in DTG and BIC susceptibility.]]>
1
100-fold. Alone, Q148H/K/R have minimal effects on DTG and BIC susceptibility. In combination with G140S/A/C and/or E138K/A/T, they cause moderate to high level reductions in DTG and BIC susceptibility. Q148N is a rare INSTI-selected mutation that causes ~3-fold reduced EVG susceptibility and may represent a reversion from Q148H or Q148K.]]>
1
1
1
1
1
1
1
15-fold. It causes minimal if any clinically significant reduction in DTG susceptibility. N155S/T are rare non-polymorphic mutations selected in vitro by investigational INSTIs. They reduce RAL and EVG susceptibility somewhat less than does N155H. $listMutsIn{155(NOT HST)} is an unusual mutation at this position.]]>
1
15-fold. It causes minimal if any clinically significant reduction in DTG susceptibility.]]>
1
15-fold. It causes minimal if any clinically significant reduction in DTG susceptibility. N155S/T are extremely rare non-polymorphic mutations selected in vitro by investigational INSTIs. They reduce RAL and EVG susceptibility somewhat less than does N155H.]]>
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
1
1
1
ABC
abacavir
5,
62V => 5,
MAX ( 65E => 10, 65N => 30, 65R => 45 ),
MAX ( 67E => 5, 67G => 5, 67H => 5, 67N => 5, 67S => 5, 67T => 5, 67d => 30 ),
68d => 15,
MAX ( 69G => 10, 69i => 60, 69d => 15 ),
MAX ( 70E => 15, 70G => 15, 70N => 15, 70Q => 15, 70R => 5, 70S => 15, 70T => 15, 70d => 15 ),
MAX ( 74I => 30, 74V => 30 ),
75I => 5,
77L => 5,
115F => 60,
116Y => 10,
MAX ( 151L => 30, 151M => 60 ),
MAX ( 184I => 15, 184V => 15 ),
210W => 5,
MAX ( 215A => 5, 215C => 5, 215D => 5, 215E => 5, 215F => 10, 215I => 5, 215L => 5, 215N => 5, 215S => 5, 215V => 5, 215Y => 10 ),
MAX ( 219E => 5, 219N => 5, 219Q => 5, 219R => 5 ),
(40F AND 41L AND 210W AND 215FY) => 5,
(41L AND 210W) => 10,
(41L AND 210W AND 215FY) => 5,
(41L AND 44AD AND 210W AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(67EGN AND 215FY AND 219ENQR) => 5,
(67EGN AND 70R AND 184IV AND 219ENQR) => 20,
(67EGN AND 70R AND 219ENQR) => 10,
(70R AND 215FY) => 5,
(74IV AND 184IV) => 15,
(77L AND 116Y AND 151M) => 10,
MAX ((210W AND 215ACDEILNSV) => 5, (210W AND 215FY) => 10),
MAX ((41L AND 215ACDEILNSV) => 5, (41L AND 215FY) => 15))]]>
AZT
zidovudine
15,
62V => 5,
MAX ( 65N => -10, 65R => -15 ),
MAX ( 67E => 10, 67G => 10, 67H => 10, 67N => 15, 67S => 10, 67T => 10, 67d => 30 ),
MAX ( 69G => 5, 69i => 60 ),
MAX ( 70E => -10, 70G => -10, 70R => 30 ),
MAX ( 75I => 5, 75M => 10 ),
77L => 10,
116Y => 10,
MAX ( 151L => 30, 151M => 60 ),
MAX ( 184I => -10, 184V => -10 ),
210W => 15,
MAX ( 215A => 20, 215C => 20, 215D => 20, 215E => 20, 215F => 40, 215I => 20, 215L => 20, 215N => 20, 215S => 20, 215V => 20, 215Y => 40 ),
MAX ( 219E => 10, 219N => 10, 219Q => 10, 219R => 10, 219W => 10 ),
(151M AND 184IV) => 10,
(40F AND 41L AND 210W AND 215FY) => 5,
(41L AND 210W) => 10,
(41L AND 44AD AND 210W AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(65R AND 151M) => 10,
(67EGN AND 215FY AND 219ENQR) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(70R AND 215FY) => 5,
(77L AND 116Y AND 151M) => 10,
MAX ((210W AND 215ACDEILNSV) => 5, (210W AND 215FY) => 10),
MAX ((41L AND 215ACDEILNSV) => 5, (41L AND 215FY) => 10))]]>
D4T
stavudine
15,
62V => 5,
MAX ( 65E => 10, 65N => 30, 65R => 60 ),
MAX ( 67E => 10, 67G => 10, 67H => 10, 67N => 15, 67S => 10, 67T => 10, 67d => 30 ),
68d => 30,
MAX ( 69D => 10, 69G => 10, 69i => 60, 69d => 30 ),
MAX ( 70E => 15, 70G => 15, 70N => 15, 70Q => 15, 70R => 15, 70S => 15, 70T => 15, 70d => 30 ),
MAX ( 75A => 30, 75I => 5, 75M => 30, 75S => 30, 75T => 60 ),
77L => 10,
116Y => 10,
MAX ( 151L => 30, 151M => 60 ),
MAX ( 184I => -10, 184V => -10 ),
210W => 15,
MAX ( 215A => 20, 215C => 20, 215D => 20, 215E => 20, 215F => 40, 215I => 20, 215L => 20, 215N => 20, 215S => 20, 215V => 20, 215Y => 40 ),
MAX ( 219E => 10, 219N => 10, 219Q => 10, 219R => 10, 219W => 10 ),
(151M AND 184IV) => 10,
(40F AND 41L AND 210W AND 215FY) => 5,
(41L AND 210W) => 10,
(41L AND 44AD AND 210W AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(67EGN AND 215FY AND 219ENQR) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(70EGNQST AND 184IV) => 10,
(70R AND 215FY) => 5,
(77L AND 116Y AND 151M) => 10,
MAX ((210W AND 215ACDEILNSV) => 5, (210W AND 215FY) => 10),
MAX ((41L AND 215ACDEILNSV) => 5, (41L AND 215FY) => 10))]]>
DDI
didanosine
10,
62V => 5,
MAX ( 65E => 10, 65N => 30, 65R => 60 ),
MAX ( 67E => 5, 67G => 5, 67H => 5, 67N => 5, 67S => 5, 67T => 5, 67d => 30 ),
68d => 30,
MAX ( 69D => 30, 69G => 10, 69i => 60, 69d => 30 ),
MAX ( 70E => 15, 70G => 15, 70N => 15, 70Q => 15, 70R => 10, 70S => 15, 70T => 15, 70d => 30 ),
MAX ( 74I => 60, 74V => 60 ),
MAX ( 75A => 15, 75I => 5, 75M => 15, 75S => 15, 75T => 30 ),
77L => 10,
116Y => 10,
MAX ( 151L => 30, 151M => 60 ),
MAX ( 184I => 10, 184V => 10 ),
210W => 10,
MAX ( 215A => 10, 215C => 10, 215D => 10, 215E => 10, 215F => 15, 215I => 10, 215L => 10, 215N => 10, 215S => 10, 215V => 10, 215Y => 15 ),
MAX ( 219E => 5, 219N => 5, 219Q => 5, 219R => 5, 219W => 5 ),
(40F AND 41L AND 210W AND 215FY) => 5,
(41L AND 210W) => 10,
(41L AND 44AD AND 210W AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(67EGN AND 215FY AND 219ENQR) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(70R AND 215FY) => 5,
(77L AND 116Y AND 151M) => 10,
MAX ((210W AND 215ACDEILNSV) => 5, (210W AND 215FY) => 10),
MAX ((41L AND 215ACDEILNSV) => 5, (41L AND 215FY) => 10))]]>
FTC
emtricitabine
5,
MAX ( 65N => 15, 65R => 30 ),
67d => 15,
68d => 15,
MAX ( 69i => 30, 69d => 15 ),
MAX ( 70E => 10, 70G => 10, 70N => 10, 70Q => 10, 70S => 10, 70T => 10, 70d => 15 ),
75I => 5,
77L => 5,
116Y => 5,
MAX ( 151L => 10, 151M => 15 ),
MAX ( 184I => 60, 184V => 60 ),
(210W AND 215FY) => 5,
(41L AND 210W AND 215FY) => 5,
(41L AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(77L AND 116Y AND 151M) => 15)]]>
3TC
lamivudine
5,
MAX ( 65N => 15, 65R => 30 ),
67d => 15,
68d => 15,
MAX ( 69i => 30, 69d => 15 ),
MAX ( 70E => 10, 70G => 10, 70N => 10, 70Q => 10, 70S => 10, 70T => 10, 70d => 15 ),
75I => 5,
77L => 5,
116Y => 5,
MAX ( 151L => 10, 151M => 15 ),
MAX ( 184I => 60, 184V => 60 ),
(210W AND 215FY) => 5,
(41L AND 210W AND 215FY) => 5,
(41L AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(77L AND 116Y AND 151M) => 15)]]>
TDF
tenofovir
5,
62V => 5,
MAX ( 65E => 10, 65N => 30, 65R => 60 ),
MAX ( 67E => 5, 67G => 5, 67H => 5, 67N => 5, 67S => 5, 67T => 5, 67d => 30 ),
68d => 15,
MAX ( 69G => 5, 69i => 60, 69d => 15 ),
MAX ( 70E => 15, 70G => 15, 70N => 15, 70Q => 15, 70R => 5, 70S => 15, 70T => 15, 70d => 15 ),
74I => 5,
75I => 5,
77L => 5,
115F => 15,
116Y => 5,
MAX ( 151L => 10, 151M => 15 ),
MAX ( 184I => -10, 184V => -10 ),
210W => 5,
MAX ( 215A => 5, 215C => 5, 215D => 5, 215E => 5, 215F => 10, 215I => 5, 215L => 5, 215N => 5, 215S => 5, 215V => 5, 215Y => 10 ),
MAX ( 219E => 5, 219N => 5, 219Q => 5, 219R => 5 ),
(151M AND 184IV) => 10,
(40F AND 41L AND 210W AND 215FY) => 5,
(41L AND 210W) => 10,
(41L AND 210W AND 215FY) => 5,
(41L AND 44AD AND 210W AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(65R AND 151M) => 10,
(67EGN AND 215FY AND 219ENQR) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(70EGNQST AND 184IV) => 10,
(70R AND 215FY) => 5,
(77L AND 116Y AND 151M) => 15,
MAX ((210W AND 215ACDEILNSV) => 5, (210W AND 215FY) => 10),
MAX ((41L AND 215ACDEILNSV) => 5, (41L AND 215FY) => 10))]]>
EFV
efavirenz
15,
MAX ( 100I => 60, 100V => 30 ),
MAX ( 101E => 15, 101H => 10, 101P => 60 ),
MAX ( 103H => 60, 103N => 60, 103S => 45, 103T => 15 ),
MAX ( 106A => 45, 106M => 60 ),
108I => 10,
MAX ( 138G => 10, 138K => 10, 138Q => 10, 138R => 10 ),
MAX ( 179D => 10, 179E => 10, 179F => 10, 179L => 10 ),
MAX ( 181C => 30, 181F => 15, 181G => 15, 181I => 30, 181S => 15, 181V => 30 ),
MAX ( 188C => 60, 188F => 60, 188H => 30, 188L => 60 ),
MAX ( 190A => 45, 190C => 60, 190E => 60, 190Q => 60, 190S => 60, 190T => 60, 190V => 60 ),
221Y => 10,
225H => 45,
MAX ( 227C => 45, 227L => 15 ),
MAX ( 230I => 15, 230L => 45 ),
MAX ( 238N => 10, 238T => 30 ),
318F => 10,
(101E AND 181C) => 5,
(103R AND 179D) => 20,
(106A AND 227L) => 15,
(98G AND 181C) => 5)]]>
ETR
etravirine
10,
MAX ( 100I => 30, 100V => 10 ),
MAX ( 101E => 15, 101H => 10, 101P => 60 ),
MAX ( 138A => 10, 138G => 10, 138K => 10, 138Q => 10, 138R => 10 ),
MAX ( 179D => 10, 179E => 10, 179F => 15, 179L => 10 ),
MAX ( 181C => 30, 181F => 15, 181G => 15, 181I => 60, 181S => 15, 181V => 60 ),
188L => 10,
MAX ( 190A => 10, 190C => 10, 190E => 45, 190Q => 45, 190S => 10, 190T => 10, 190V => 10 ),
221Y => 10,
227C => 30,
MAX ( 230I => 15, 230L => 30 ),
(101E AND 181C) => 5,
(101E AND 188L) => 5,
(181C AND 190ACSTV) => 10,
(98G AND 181C) => 5,
MAX ((101E AND 190A) => 5, (101E AND 190S) => 5),
MAX ((179F AND 181C) => 15, (179T AND 181C) => 10))]]>
NVP
nevirapine
30,
MAX ( 100I => 60, 100V => 30 ),
MAX ( 101E => 30, 101H => 15, 101P => 60 ),
MAX ( 103H => 60, 103N => 60, 103S => 60, 103T => 60 ),
MAX ( 106A => 60, 106M => 60 ),
108I => 15,
MAX ( 138G => 10, 138K => 10, 138Q => 10, 138R => 10 ),
MAX ( 179D => 10, 179E => 10, 179F => 15, 179L => 10 ),
MAX ( 181C => 60, 181F => 60, 181G => 60, 181I => 60, 181S => 60, 181V => 60 ),
MAX ( 188C => 60, 188F => 60, 188H => 60, 188L => 60 ),
MAX ( 190A => 60, 190C => 60, 190E => 60, 190Q => 60, 190S => 60, 190T => 60, 190V => 60 ),
221Y => 15,
225H => 45,
MAX ( 227C => 45, 227L => 30 ),
MAX ( 230I => 30, 230L => 60 ),
MAX ( 238N => 10, 238T => 30 ),
318F => 30,
348I => 15,
(101E AND 181C) => 5,
(103R AND 179D) => 20,
(98G AND 181C) => 5)]]>
RPV
rilpivirine
15,
MAX ( 100I => 60, 100V => 15 ),
MAX ( 101E => 45, 101H => 10, 101P => 60 ),
MAX ( 138A => 15, 138G => 15, 138K => 45, 138Q => 15, 138R => 15 ),
MAX ( 179D => 10, 179E => 10, 179F => 15, 179L => 15 ),
MAX ( 181C => 45, 181F => 30, 181G => 30, 181I => 60, 181S => 30, 181V => 60 ),
MAX ( 188F => 30, 188L => 60 ),
MAX ( 190A => 15, 190C => 10, 190E => 60, 190Q => 45, 190S => 15, 190T => 10, 190V => 10 ),
221Y => 15,
227C => 45,
MAX ( 230I => 30, 230L => 60 ),
(101E AND 184I) => 15,
(103R AND 179D) => 15,
(138K AND 184I) => 15,
(181C AND 190ACSTV) => 10,
(98G AND 181C) => 5,
MAX ((179F AND 181C) => 15, (179T AND 181C) => 10))]]>
ATV/r
atazanavir/r
5,
MAX ( 24F => 5, 24I => 10, 24M => 5 ),
32I => 15,
33F => 5,
MAX ( 46I => 10, 46L => 10, 46V => 10 ),
47V => 10,
MAX ( 48A => 10, 48L => 10, 48M => 30, 48Q => 10, 48S => 10, 48T => 10, 48V => 30 ),
50L => 60,
53L => 10,
MAX ( 54A => 15, 54L => 15, 54M => 15, 54S => 15, 54T => 15, 54V => 15 ),
MAX ( 73A => 10, 73C => 10, 73D => 5, 73S => 10, 73T => 10, 73V => 5 ),
74P => 10,
MAX ( 82A => 15, 82C => 15, 82F => 15, 82L => 10, 82M => 10, 82S => 30, 82T => 30 ),
83D => 10,
MAX ( 84A => 60, 84C => 60, 84V => 60 ),
MAX ( 88D => 10, 88G => 15, 88S => 60, 88T => 15 ),
90M => 25,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 82ACFLMST) => 10,
(46ILV AND 90M) => 10,
(47AV AND 54LM) => 5,
(53L AND 90M) => 10,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 10,
(73ACSTV AND 90M) => 10,
(82ACFLMST AND 90M) => 10)]]>
DRV/r
darunavir/r
5,
32I => 15,
33F => 5,
MAX ( 47A => 10, 47V => 10 ),
MAX ( 50L => -10, 50V => 20 ),
MAX ( 54L => 20, 54M => 20 ),
74P => 5,
76V => 20,
82F => 15,
MAX ( 84A => 30, 84C => 15, 84V => 15 ),
88S => -5,
89V => 5,
(11IL AND 32I) => 5,
(11IL AND 54LM) => 5,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(32I AND 76V) => 5,
(32I AND 84V) => 5,
(32I AND 89V) => 5,
(47AV AND 54LM) => 5,
(47AV AND 84V) => 5,
(54LM AND 84V) => 5,
(54LM AND 89V) => 5)]]>
FPV/r
fosamprenavir/r
15,
20T => 5,
MAX ( 24F => 5, 24I => 10, 24M => 5 ),
32I => 30,
33F => 10,
MAX ( 46I => 10, 46L => 10, 46V => 10 ),
MAX ( 47A => 60, 47V => 35 ),
MAX ( 50L => -5, 50V => 60 ),
MAX ( 54A => 10, 54L => 60, 54M => 60, 54S => 10, 54T => 10, 54V => 10 ),
MAX ( 73A => 10, 73C => 10, 73D => 5, 73S => 10, 73T => 10, 73V => 5 ),
74P => 10,
76V => 60,
MAX ( 82A => 15, 82C => 15, 82F => 30, 82L => 15, 82M => 15, 82S => 15, 82T => 15 ),
MAX ( 84A => 60, 84C => 60, 84V => 60 ),
88S => -10,
89V => 10,
90M => 20,
(11IL AND 32I) => 5,
(11IL AND 54LM) => 5,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(32I AND 76V) => 5,
(32I AND 84V) => 5,
(32I AND 89V) => 5,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 76V) => 10,
(46ILV AND 82ACFLMST) => 10,
(46ILV AND 90M) => 10,
(47AV AND 54LM) => 5,
(47AV AND 84V) => 5,
(53L AND 90M) => 10,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 10,
(54LM AND 84V) => 5,
(54LM AND 89V) => 5,
(73ACSTV AND 90M) => 10,
(82ACFLMST AND 90M) => 10)]]>
IDV/r
indinavir/r
10,
20T => 5,
MAX ( 24F => 5, 24I => 15, 24M => 5 ),
32I => 15,
33F => 5,
MAX ( 46I => 10, 46L => 10, 46V => 10 ),
MAX ( 47A => 15, 47V => 15 ),
MAX ( 48A => 10, 48L => 10, 48M => 10, 48Q => 10, 48S => 10, 48T => 10, 48V => 10 ),
50L => -5,
MAX ( 54A => 15, 54L => 10, 54M => 15, 54S => 15, 54T => 15, 54V => 15 ),
MAX ( 73A => 15, 73C => 15, 73D => 5, 73S => 15, 73T => 15, 73V => 5 ),
74P => 10,
76V => 30,
MAX ( 82A => 30, 82C => 15, 82F => 30, 82L => 10, 82M => 30, 82S => 30, 82T => 30 ),
83D => 10,
MAX ( 84A => 60, 84C => 60, 84V => 60 ),
88S => 15,
89V => 5,
90M => 30,
(11IL AND 32I) => 5,
(11IL AND 54LM) => 5,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(32I AND 76V) => 5,
(32I AND 84V) => 5,
(32I AND 89V) => 5,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 76V) => 10,
(46ILV AND 82ACFLMST) => 10,
(46ILV AND 90M) => 10,
(47AV AND 54LM) => 5,
(47AV AND 84V) => 5,
(53L AND 90M) => 10,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 10,
(54LM AND 84V) => 5,
(54LM AND 89V) => 5,
(73ACSTV AND 90M) => 10,
(82ACFLMST AND 90M) => 10)]]>
LPV/r
lopinavir/r
5,
MAX ( 24F => 5, 24I => 10, 24M => 5 ),
32I => 15,
33F => 5,
MAX ( 46I => 10, 46L => 10, 46V => 5 ),
MAX ( 47A => 60, 47V => 15 ),
MAX ( 48A => 10, 48L => 10, 48M => 10, 48Q => 10, 48S => 10, 48T => 10, 48V => 10 ),
MAX ( 50L => -10, 50V => 30 ),
MAX ( 54A => 15, 54L => 20, 54M => 20, 54S => 15, 54T => 15, 54V => 15 ),
MAX ( 73A => 5, 73C => 5, 73D => 5, 73S => 5, 73T => 5, 73V => 5 ),
74P => 5,
76V => 30,
MAX ( 82A => 30, 82C => 15, 82F => 30, 82L => 10, 82M => 25, 82S => 30, 82T => 30 ),
MAX ( 84A => 60, 84C => 30, 84V => 30 ),
90M => 15,
(11IL AND 32I) => 5,
(11IL AND 54LM) => 5,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(32I AND 76V) => 5,
(32I AND 84V) => 5,
(32I AND 89V) => 5,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 76V) => 10,
(46ILV AND 82ACFLMST) => 10,
(47AV AND 54LM) => 5,
(47AV AND 84V) => 5,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 5,
(54LM AND 84V) => 5,
(54LM AND 89V) => 5,
(82ACFLMST AND 90M) => 5)]]>
NFV
nelfinavir
15,
20T => 15,
23I => 15,
MAX ( 24F => 10, 24I => 10, 24M => 10 ),
30N => 60,
32I => 15,
33F => 10,
43T => 10,
MAX ( 46I => 30, 46L => 20, 46V => 20 ),
MAX ( 47A => 30, 47V => 20 ),
MAX ( 48A => 30, 48L => 30, 48M => 30, 48Q => 30, 48S => 30, 48T => 30, 48V => 30 ),
50V => 15,
53L => 10,
MAX ( 54A => 20, 54L => 20, 54M => 20, 54S => 20, 54T => 20, 54V => 20 ),
58E => 10,
MAX ( 73A => 15, 73C => 15, 73D => 10, 73S => 15, 73T => 15, 73V => 10 ),
74P => 20,
76V => 10,
MAX ( 82A => 30, 82C => 30, 82F => 30, 82L => 10, 82M => 30, 82S => 30, 82T => 30 ),
83D => 15,
MAX ( 84A => 60, 84C => 60, 84V => 60 ),
MAX ( 88D => 60, 88G => 30, 88S => 60, 88T => 30 ),
89V => 10,
90M => 60,
(11IL AND 32I) => 5,
(11IL AND 54LM) => 5,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(32I AND 76V) => 5,
(32I AND 84V) => 5,
(32I AND 89V) => 5,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 76V) => 10,
(46ILV AND 82ACFLMST) => 10,
(46ILV AND 90M) => 10,
(47AV AND 54LM) => 5,
(47AV AND 84V) => 5,
(53L AND 90M) => 10,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 10,
(54LM AND 84V) => 5,
(54LM AND 89V) => 5,
(73ACSTV AND 90M) => 10,
(82ACFLMST AND 90M) => 10)]]>
SQV/r
saquinavir/r
5,
MAX ( 24F => 5, 24I => 10, 24M => 5 ),
33F => 5,
MAX ( 46I => 10, 46L => 10, 46V => 5 ),
MAX ( 48A => 60, 48L => 60, 48M => 60, 48Q => 60, 48S => 60, 48T => 60, 48V => 60 ),
MAX ( 50L => -5, 50V => 15 ),
53L => 15,
MAX ( 54A => 15, 54L => 15, 54M => 15, 54S => 15, 54T => 15, 54V => 15 ),
MAX ( 73A => 15, 73C => 15, 73D => 10, 73S => 15, 73T => 15, 73V => 10 ),
74P => 10,
MAX ( 82A => 15, 82C => 15, 82F => 10, 82L => 10, 82M => 15, 82S => 15, 82T => 15 ),
83D => 10,
MAX ( 84A => 60, 84C => 60, 84V => 60 ),
MAX ( 88D => 10, 88S => 15 ),
90M => 45,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 82ACFLMST) => 10,
(46ILV AND 90M) => 5,
(53L AND 90M) => 10,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 10,
(73ACSTV AND 90M) => 10,
(82ACFLMST AND 90M) => 10)]]>
TPV/r
tipranavir/r
-5,
32I => 5,
33F => 10,
43T => 10,
MAX ( 46I => 5, 46L => 10, 46V => 5 ),
MAX ( 47A => 30, 47V => 30 ),
MAX ( 50L => -5, 50V => -5 ),
MAX ( 54A => 20, 54L => -10, 54M => 20, 54S => 20, 54T => 20, 54V => 20 ),
58E => 15,
74P => 25,
76V => -5,
MAX ( 82C => 10, 82L => 45, 82M => 10, 82S => 30, 82T => 45 ),
83D => 25,
MAX ( 84A => 60, 84C => 30, 84V => 30 ),
(46IL AND 84V AND 90M) => 5)]]>
BIC
bictegravir
10,
MAX ( 66I => 5, 66K => 15 ),
92Q => 10,
118R => 15,
121Y => 10,
MAX ( 138A => 10, 138K => 10, 138T => 10 ),
MAX ( 140A => 10, 140C => 10, 140S => 10 ),
MAX ( 143A => 5, 143C => 5, 143G => 5, 143H => 5, 143K => 5, 143R => 5, 143S => 5 ),
MAX ( 148H => 25, 148K => 30, 148R => 25 ),
151L => 15,
MAX ( 153F => 15, 153Y => 15 ),
155H => 10,
230R => 10,
263K => 25,
(138AKT AND 140ACS) => 10,
(138AKT AND 148HKR) => 10,
(140ACS AND 148HKR) => 10,
(143ACGHRS AND 163R) => 5,
(143ACGHRS AND 230R) => 5,
(148HKR AND 155H) => 10,
(148HKR AND 163KR) => 5,
(157Q AND 263K) => 10,
(51Y AND 263K) => 10,
(74FM AND 143ACGHRS) => 5,
(74FM AND 148HKR) => 10,
(92Q AND 155H) => 5,
(97A AND 148HKR) => 10)]]>
DTG
dolutegravir
10,
MAX ( 66I => 5, 66K => 15 ),
92Q => 10,
118R => 15,
121Y => 10,
MAX ( 138A => 10, 138K => 10, 138T => 10 ),
MAX ( 140A => 10, 140C => 10, 140S => 10 ),
MAX ( 143A => 5, 143C => 5, 143G => 5, 143H => 5, 143K => 5, 143R => 5, 143S => 5 ),
MAX ( 148H => 25, 148K => 30, 148R => 25 ),
151L => 15,
MAX ( 153F => 15, 153Y => 15 ),
155H => 10,
230R => 20,
263K => 25,
(138AKT AND 140ACS) => 10,
(138AKT AND 148HKR) => 10,
(140ACS AND 148HKR) => 10,
(143ACGHRS AND 163R) => 5,
(143ACGHRS AND 230R) => 5,
(148HKR AND 155H) => 10,
(148HKR AND 163KR) => 5,
(157Q AND 263K) => 10,
(51Y AND 263K) => 10,
(74FM AND 143ACGHRS) => 5,
(74FM AND 148HKR) => 10,
(92Q AND 155H) => 5,
(97A AND 148HKR) => 10)]]>
EVG
elvitegravir
15,
MAX ( 66A => 60, 66I => 60, 66K => 60 ),
MAX ( 92G => 30, 92Q => 60, 92V => 60 ),
95K => 10,
97A => 10,
118R => 30,
121Y => 60,
MAX ( 138A => 15, 138K => 15, 138T => 15 ),
MAX ( 140A => 30, 140C => 30, 140S => 30 ),
MAX ( 143A => 10, 143C => 10, 143G => 10, 143H => 10, 143K => 10, 143R => 10, 143S => 10 ),
145S => 60,
146P => 60,
147G => 60,
MAX ( 148H => 60, 148K => 60, 148N => 15, 148R => 60 ),
MAX ( 151A => 30, 151L => 60 ),
MAX ( 153F => 15, 153Y => 15 ),
MAX ( 155H => 60, 155S => 30, 155T => 30 ),
157Q => 10,
MAX ( 163K => 15, 163R => 15 ),
230R => 20,
263K => 30,
(138AKT AND 140ACS) => 15,
(143ACGHRS AND 163R) => 5,
(143ACGHRS AND 230R) => 5,
(51Y AND 263K) => 15,
(74FM AND 143ACGHRS) => 5,
(74FM AND 148HKR) => 10,
(97A AND 143ACGHRS) => 5)]]>
RAL
raltegravir
15,
MAX ( 66A => 15, 66I => 15, 66K => 60 ),
MAX ( 92G => 15, 92Q => 30, 92V => 30 ),
95K => 10,
97A => 10,
118R => 30,
121Y => 60,
MAX ( 138A => 15, 138K => 15, 138T => 15 ),
MAX ( 140A => 30, 140C => 30, 140S => 30 ),
MAX ( 143A => 60, 143C => 60, 143G => 60, 143H => 60, 143K => 60, 143R => 60, 143S => 60 ),
MAX ( 148H => 60, 148K => 60, 148N => 10, 148R => 60 ),
MAX ( 151A => 15, 151L => 30 ),
MAX ( 155H => 60, 155S => 30, 155T => 30 ),
157Q => 10,
MAX ( 163K => 15, 163R => 15 ),
230R => 20,
263K => 25,
(138AKT AND 140ACS) => 15,
(74FM AND 148HKR) => 10)]]>
PR
10ACDEGHKMNPQSTWid
10F
10IV
10RY
11IL
20I
20MV
20R
20T
23I
24ACDEGHKNPQRSTVWYid
24FM
24I
30ACEFGHIKLMPQRSTVWYid
30N
32ACDEFGHKLMNPQRSTWYid
32I
33F
43T
46ACDEFGHKNPQRSTWYid
46IL
46V
47A
47CDEFGHKLMNPQRSTWYid
47V
48ASTQL
48CDEFHIKNPRWYid
48M
48V
50ACDEFGHKMNPQRSTWYid
50L
50V
53L
53Y
54ATS
54CDEFGHKNPQRWYid
54LM
54V
58E
71IL
71TV
73EFHIKLMNPQRWYid
73STCADV
74P
74S
76ACDEFGHIKMNPQRSTWYid
76V
82A
82C
82DEGHKNPQRWYid
82F
82I
82L
82M
82TS
83D
84AC
84DEFGHKLMNPQRSTWYid
84V
85V
88ACEFHIKLMPQRVWYid
88D
88S
88TG
89VT
90ACDEFGHIKNPQRSTVWYid
90M
IN
118ACDEFHIKLMNPQSTVWYid
118R
121ACDEGHIKLMNPQRSTVWid
121Y
128T
138CFGHILMNPQRSVWYid
138D
138KAT
140DEFHIKLMNPQRTVWYid
140SAC
143CR
143DEFILMNPQTVWid
143H
143KGSA
145ACDEFGHIKLMNQRTVWYid
145S
146ACDEFGHIKLMNRSTVWYid
146P
147ACDEFHIKLMNPQRTVWYid
147G
148ACDEFGILMPSTVWYid
148HKR
148N
151A
151CDEFGHKMNPQRSTWYid
151I
151L
153ACDEGHIKLMNPQRTVWid
153YF
155ACDEFGIKLMPQRVWYid
155H
155ST
157Q
163RK
230N
230R
263ACDEFGHILMNPQSTVWYid
263K
51ACDEFGIKLMNPQRSTVWid
51Y
66A
66CDEFGHLMNPQRSVWYid
66I
66K
74MI
92ACDFHIKLMNPRSTWYid
92G
92Q
92V
95K
97A
RT
100ACDEFGHKMNPQRSTWYid
100I
100V
101CDFGILMSVWYid
101E
101H
101NAT
101P
101Q
103ACDFGILMPVWYid
103EQ
103H
103N
103R
103S
103T
106A
106CDEFGHKLNPQRSTWYid
106I
106M
108ACDEFGHKLMNPQRSTWYid
108I
115ACDEGHIKLMNPQRSTVWid
115F
116ACDEGHIKLMNPQRSTVWid
116Y
118I
132ML
138A
138CDFHILMNPSTVWYid
138K
138QG
138R
151ACDEFGHIKNPRSTVWYid
151L
151M
179ACGHKMNPQRSWYid
179DE
179F
179I
179L
179T
181ADEHKLMNPQRTWid
181C
181FSG
181IV
184ACDEFGHKLNPQRSTWYid
184VI
188ADEGIKMNPQRSTVWid
188C
188F
188H
188L
190A
190CTV
190DFHIKLMNPRWYid
190EQ
190S
210W
215F
215GHKMPQRWid
215SCDEIVALN
215Y
219ACDFGHILMPSTVYid
219NR
219QE
219W
221Y
225ACDEFGIKLMNQRSTVWYid
225H
227ADEGHIKMNPQRSTVWYid
227C
227L
230ACDEFGHKNPQRSTVWYid
230I
230L
236ACDEFGHIKMNQRSTVWYid
236L
238ACDEFGHILMPQSVWYid
238R
238TN
318ACDEGHIKLMNPQRSTVWid
318F
348ACDEFGHKLMPQRSTVWYid
348I
40F
41I
41L
44AD
62V
65ACDFGHILMPQSTVWYid
65E
65N
65R
67d
67ACFIKLMPQRVWYi
67GESTH
67N
68d
68G
69d
69CFHKLMPQRVWY
69D
69G
69N
69SAIE
69i
70d
70ACDFHILMPVWYi
70EG
70QNST
70R
74ACDEFGHKMNPQRSTWYid
74VI
75CDEFGHKNPQRWYid
75I
75M
75SA
75T
77ACDEGHIKMNPQRSTVWYid
77L
90I
98G