HIVDB
8.1.1
2016-09-23
PR
PI
RT
NRTI,NNRTI
IN
INSTI
1
Susceptible
S
2
Potential Low-Level Resistance
S
3
Low-Level Resistance
I
4
Intermediate Resistance
I
5
High-Level Resistance
R
NRTI
ABC,AZT,D4T,DDI,FTC,3TC,TDF
NNRTI
EFV,ETR,NVP,RPV
PI
ATV/r,DRV/r,FPV/r,IDV/r,LPV/r,NFV,SQV/r,TPV/r
INSTI
DTG,EVG,RAL
1, 10 TO 14 => 2, 15 TO 29 => 3, 30 TO 59 => 4, 60 TO INF => 5)]]>
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
50-fold, 5-fold, 3-fold, and 2-fold, respectively. Although Y181C itself reduces EFV susceptibility by only 2-fold, it has been associated with a reduced response to an EFV-containing regimen in NNRTI-experienced patients. Y181C has a weight of 2.5 in the Tibotec ETR genotypic susceptibility score.]]>
1
1
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5-fold reduced susceptibility to each of the INSTIs.]]>
1
5-fold reduced susceptibility to each of the INSTIs. $listMutsIn{118(NOT R)} is an unusual mutation at this position.]]>
1
1
1
1
100-fold reduced RAL and EVG susceptibility and up to 10-fold reduced DTG susceptibility when they occur in combination with Q148 mutations. E138T is a rare nonpolymorphic INSTI-selected mutation that appears to have an effect similar to E138K/A.]]>
1
1
1
100-fold reduction in RAL and EVG susceptibility and an up to 10-fold reduction in DTG susceptibility.]]>
1
100-fold reduction in RAL and EVG susceptibility and an up to 10-fold reduction in DTG susceptibility. $listMutsIn{140(NOT SAC)} is an unusual mutation at this position.]]>
1
100-fold. Alone, Y143C/R have minimal effects on EVG susceptibility. However, they are associated with ~10-fold reduced EVG susceptibility when they occur in combination with one or more INSTI-resistance mutations. Y143 mutations do not reduce DTG susceptibility.]]>
1
100-fold. Y143H is a less-common mutation at this position that is likely a transitional mutation between the wildtype Y amino acid and the mutant R which differs from Y by two bases.]]>
1
1
100-fold. Alone, Y143C/R have minimal effects on EVG susceptibility. However, they are associated with ~10-fold reduced EVG susceptibility when they occur in combination with two or more accessory INSTI-resistance mutations. Y143 mutations do not reduce DTG susceptibility. $listMutsIn{143(NOT CRHKGSA)} is an unusual mutation at this position.]]>
1
1
1
1
1
1
1
100-fold. Alone, Q148H/K/R have minimal effects on DTG susceptibility. In combination with G140S/A/C and/or E138K/A, they reduce DTG susceptibility up to 10-fold.]]>
1
100-fold. In combination with G140S/A/C and/or E138K/A, they reduce DTG susceptibility >10-fold. Q148N is a rare INSTI-selected mutation that causes ~3-fold reduced EVG susceptibility and may represent a reversion from Q148H or Q148K.]]>
1
100-fold. Alone, Q148H/K/R have minimal effects on DTG susceptibility. In combination with G140S/A/C and/or E138K/A, they reduce DTG susceptibility up to 10-fold. $listMutsIn{148(NOT HKRN)} is an unusual mutation at this position.]]>
1
1
1
1
1
1
1
1
1
1
1
1
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1
1
1
ABC
abacavir
5,
62V => 5,
MAX ( 65E => 10, 65N => 30, 65R => 45 ),
MAX ( 67E => 5, 67G => 5, 67H => 5, 67N => 5, 67S => 5, 67T => 5, 67d => 30 ),
68d => 15,
MAX ( 69G => 10, 69i => 60, 69d => 15 ),
MAX ( 70E => 15, 70G => 15, 70N => 15, 70Q => 15, 70R => 5, 70S => 15, 70T => 15, 70d => 15 ),
MAX ( 74I => 30, 74V => 30 ),
75I => 5,
77L => 5,
115F => 60,
116Y => 10,
MAX ( 151L => 30, 151M => 60 ),
MAX ( 184I => 15, 184V => 15 ),
210W => 5,
MAX ( 215A => 5, 215C => 5, 215D => 5, 215E => 5, 215F => 10, 215I => 5, 215L => 5, 215N => 5, 215S => 5, 215V => 5, 215Y => 10 ),
MAX ( 219E => 5, 219N => 5, 219Q => 5, 219R => 5 ),
(40F AND 41L AND 210W AND 215FY) => 5,
(41L AND 210W) => 10,
(41L AND 210W AND 215FY) => 5,
(41L AND 44AD AND 210W AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(67EGN AND 215FY AND 219ENQR) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(70R AND 215FY) => 5,
(74IV AND 184IV) => 15,
(77L AND 116Y AND 151M) => 10,
MAX ((210W AND 215ACDEILNSV) => 5, (210W AND 215FY) => 10),
MAX ((41L AND 215ACDEILNSV) => 5, (41L AND 215FY) => 10))]]>
AZT
zidovudine
15,
62V => 5,
MAX ( 65N => -10, 65R => -15 ),
MAX ( 67E => 10, 67G => 10, 67H => 10, 67N => 15, 67S => 10, 67T => 10, 67d => 30 ),
MAX ( 69G => 5, 69i => 60 ),
MAX ( 70E => -10, 70G => -10, 70R => 30 ),
MAX ( 75I => 5, 75M => 10 ),
77L => 10,
116Y => 10,
MAX ( 151L => 30, 151M => 60 ),
MAX ( 184I => -10, 184V => -10 ),
210W => 15,
MAX ( 215A => 20, 215C => 20, 215D => 20, 215E => 20, 215F => 40, 215I => 20, 215L => 20, 215N => 20, 215S => 20, 215V => 20, 215Y => 40 ),
MAX ( 219E => 10, 219N => 10, 219Q => 10, 219R => 10, 219W => 10 ),
(151M AND 184IV) => 10,
(40F AND 41L AND 210W AND 215FY) => 5,
(41L AND 210W) => 10,
(41L AND 44AD AND 210W AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(65R AND 151M) => 10,
(67EGN AND 215FY AND 219ENQR) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(70R AND 215FY) => 5,
(77L AND 116Y AND 151M) => 10,
MAX ((210W AND 215ACDEILNSV) => 5, (210W AND 215FY) => 10),
MAX ((41L AND 215ACDEILNSV) => 5, (41L AND 215FY) => 10))]]>
D4T
stavudine
15,
62V => 5,
MAX ( 65E => 10, 65N => 30, 65R => 60 ),
MAX ( 67E => 10, 67G => 10, 67H => 10, 67N => 15, 67S => 10, 67T => 10, 67d => 30 ),
68d => 30,
MAX ( 69D => 10, 69G => 10, 69i => 60, 69d => 30 ),
MAX ( 70E => 15, 70G => 15, 70N => 15, 70Q => 15, 70R => 15, 70S => 15, 70T => 15, 70d => 30 ),
MAX ( 75A => 30, 75I => 5, 75M => 30, 75S => 30, 75T => 60 ),
77L => 10,
116Y => 10,
MAX ( 151L => 30, 151M => 60 ),
MAX ( 184I => -10, 184V => -10 ),
210W => 15,
MAX ( 215A => 20, 215C => 20, 215D => 20, 215E => 20, 215F => 40, 215I => 20, 215L => 20, 215N => 20, 215S => 20, 215V => 20, 215Y => 40 ),
MAX ( 219E => 10, 219N => 10, 219Q => 10, 219R => 10, 219W => 10 ),
(151M AND 184IV) => 10,
(40F AND 41L AND 210W AND 215FY) => 5,
(41L AND 210W) => 10,
(41L AND 44AD AND 210W AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(67EGN AND 215FY AND 219ENQR) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(70EGNQST AND 184IV) => 10,
(70R AND 215FY) => 5,
(77L AND 116Y AND 151M) => 10,
MAX ((210W AND 215ACDEILNSV) => 5, (210W AND 215FY) => 10),
MAX ((41L AND 215ACDEILNSV) => 5, (41L AND 215FY) => 10))]]>
DDI
didanosine
10,
62V => 5,
MAX ( 65E => 10, 65N => 30, 65R => 60 ),
MAX ( 67E => 5, 67G => 5, 67H => 5, 67N => 5, 67S => 5, 67T => 5, 67d => 30 ),
68d => 30,
MAX ( 69D => 30, 69G => 10, 69i => 60, 69d => 30 ),
MAX ( 70E => 15, 70G => 15, 70N => 15, 70Q => 15, 70R => 10, 70S => 15, 70T => 15, 70d => 30 ),
MAX ( 74I => 60, 74V => 60 ),
MAX ( 75A => 15, 75I => 5, 75M => 15, 75S => 15, 75T => 30 ),
77L => 10,
116Y => 10,
MAX ( 151L => 30, 151M => 60 ),
MAX ( 184I => 10, 184V => 10 ),
210W => 10,
MAX ( 215A => 10, 215C => 10, 215D => 10, 215E => 10, 215F => 15, 215I => 10, 215L => 10, 215N => 10, 215S => 10, 215V => 10, 215Y => 15 ),
MAX ( 219E => 5, 219N => 5, 219Q => 5, 219R => 5, 219W => 5 ),
(40F AND 41L AND 210W AND 215FY) => 5,
(41L AND 210W) => 10,
(41L AND 44AD AND 210W AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(67EGN AND 215FY AND 219ENQR) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(70R AND 215FY) => 5,
(77L AND 116Y AND 151M) => 10,
MAX ((210W AND 215ACDEILNSV) => 5, (210W AND 215FY) => 10),
MAX ((41L AND 215ACDEILNSV) => 5, (41L AND 215FY) => 10))]]>
FTC
emtricitabine
5,
MAX ( 65N => 15, 65R => 30 ),
67d => 15,
68d => 15,
MAX ( 69i => 30, 69d => 15 ),
MAX ( 70E => 10, 70G => 10, 70N => 10, 70Q => 10, 70S => 10, 70T => 10, 70d => 15 ),
75I => 5,
77L => 5,
116Y => 5,
MAX ( 151L => 10, 151M => 15 ),
MAX ( 184I => 60, 184V => 60 ),
(210W AND 215FY) => 5,
(41L AND 210W AND 215FY) => 5,
(41L AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(77L AND 116Y AND 151M) => 15)]]>
3TC
lamivudine
5,
MAX ( 65N => 15, 65R => 30 ),
67d => 15,
68d => 15,
MAX ( 69i => 30, 69d => 15 ),
MAX ( 70E => 10, 70G => 10, 70N => 10, 70Q => 10, 70S => 10, 70T => 10, 70d => 15 ),
75I => 5,
77L => 5,
116Y => 5,
MAX ( 151L => 10, 151M => 15 ),
MAX ( 184I => 60, 184V => 60 ),
(210W AND 215FY) => 5,
(41L AND 210W AND 215FY) => 5,
(41L AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(77L AND 116Y AND 151M) => 15)]]>
TDF
tenofovir
5,
62V => 5,
MAX ( 65E => 10, 65N => 30, 65R => 60 ),
MAX ( 67E => 5, 67G => 5, 67H => 5, 67N => 5, 67S => 5, 67T => 5, 67d => 30 ),
68d => 15,
MAX ( 69G => 5, 69i => 60, 69d => 15 ),
MAX ( 70E => 15, 70G => 15, 70N => 15, 70Q => 15, 70R => 5, 70S => 15, 70T => 15, 70d => 15 ),
74I => 5,
75I => 5,
77L => 5,
115F => 15,
116Y => 5,
MAX ( 151L => 10, 151M => 15 ),
MAX ( 184I => -10, 184V => -10 ),
210W => 5,
MAX ( 215A => 5, 215C => 5, 215D => 5, 215E => 5, 215F => 10, 215I => 5, 215L => 5, 215N => 5, 215S => 5, 215V => 5, 215Y => 10 ),
MAX ( 219E => 5, 219N => 5, 219Q => 5, 219R => 5 ),
(151M AND 184IV) => 10,
(40F AND 41L AND 210W AND 215FY) => 5,
(41L AND 210W) => 10,
(41L AND 210W AND 215FY) => 5,
(41L AND 44AD AND 210W AND 215FY) => 5,
(41L AND 67EGN AND 215FY) => 5,
(65R AND 151M) => 10,
(67EGN AND 215FY AND 219ENQR) => 5,
(67EGN AND 70R AND 219ENQR) => 10,
(70EGNQST AND 184IV) => 10,
(70R AND 215FY) => 5,
(77L AND 116Y AND 151M) => 15,
MAX ((210W AND 215ACDEILNSV) => 5, (210W AND 215FY) => 10),
MAX ((41L AND 215ACDEILNSV) => 5, (41L AND 215FY) => 10))]]>
EFV
efavirenz
15,
MAX ( 100I => 60, 100V => 30 ),
MAX ( 101E => 15, 101H => 10, 101P => 60 ),
MAX ( 103H => 60, 103N => 60, 103S => 45, 103T => 15 ),
MAX ( 106A => 45, 106M => 60 ),
108I => 10,
MAX ( 138G => 10, 138K => 10, 138Q => 10, 138R => 10 ),
MAX ( 179D => 10, 179E => 10, 179F => 10, 179L => 10 ),
MAX ( 181C => 30, 181F => 15, 181G => 15, 181I => 30, 181S => 15, 181V => 30 ),
MAX ( 188C => 60, 188F => 60, 188H => 30, 188L => 60 ),
MAX ( 190A => 45, 190C => 60, 190E => 60, 190Q => 60, 190S => 60, 190T => 60, 190V => 60 ),
221Y => 10,
225H => 45,
MAX ( 227C => 45, 227L => 15 ),
MAX ( 230I => 15, 230L => 45 ),
MAX ( 238N => 10, 238T => 30 ),
318F => 10,
(101E AND 181C) => 5,
(103R AND 179D) => 20,
(106A AND 227L) => 15,
(98G AND 181C) => 5)]]>
ETR
etravirine
10,
MAX ( 100I => 30, 100V => 10 ),
MAX ( 101E => 15, 101H => 10, 101P => 60 ),
MAX ( 138A => 10, 138G => 10, 138K => 10, 138Q => 10, 138R => 10 ),
MAX ( 179D => 10, 179E => 10, 179F => 15, 179L => 10 ),
MAX ( 181C => 30, 181F => 15, 181G => 15, 181I => 60, 181S => 15, 181V => 60 ),
188L => 10,
MAX ( 190A => 10, 190C => 10, 190E => 45, 190Q => 45, 190S => 10, 190T => 10, 190V => 10 ),
221Y => 10,
227C => 30,
MAX ( 230I => 15, 230L => 30 ),
(101E AND 181C) => 5,
(101E AND 188L) => 5,
(181C AND 190ACSTV) => 10,
(98G AND 181C) => 5,
MAX ((101E AND 190A) => 5, (101E AND 190S) => 5),
MAX ((179F AND 181C) => 15, (179T AND 181C) => 10))]]>
NVP
nevirapine
30,
MAX ( 100I => 60, 100V => 30 ),
MAX ( 101E => 30, 101H => 15, 101P => 60 ),
MAX ( 103H => 60, 103N => 60, 103S => 60, 103T => 60 ),
MAX ( 106A => 60, 106M => 60 ),
108I => 15,
MAX ( 138G => 10, 138K => 10, 138Q => 10, 138R => 10 ),
MAX ( 179D => 10, 179E => 10, 179F => 15, 179L => 10 ),
MAX ( 181C => 60, 181F => 60, 181G => 60, 181I => 60, 181S => 60, 181V => 60 ),
MAX ( 188C => 60, 188F => 60, 188H => 60, 188L => 60 ),
MAX ( 190A => 60, 190C => 60, 190E => 60, 190Q => 60, 190S => 60, 190T => 60, 190V => 60 ),
221Y => 15,
225H => 45,
MAX ( 227C => 45, 227L => 30 ),
MAX ( 230I => 30, 230L => 60 ),
MAX ( 238N => 10, 238T => 30 ),
318F => 30,
348I => 15,
(101E AND 181C) => 5,
(103R AND 179D) => 20,
(98G AND 181C) => 5)]]>
RPV
rilpivirine
15,
MAX ( 100I => 60, 100V => 15 ),
MAX ( 101E => 45, 101H => 10, 101P => 60 ),
MAX ( 138A => 15, 138G => 15, 138K => 45, 138Q => 15, 138R => 15 ),
MAX ( 179D => 10, 179E => 10, 179F => 15, 179L => 15 ),
MAX ( 181C => 45, 181F => 30, 181G => 30, 181I => 60, 181S => 30, 181V => 60 ),
MAX ( 188F => 30, 188L => 60 ),
MAX ( 190A => 15, 190C => 10, 190E => 60, 190Q => 45, 190S => 15, 190T => 10, 190V => 10 ),
221Y => 15,
227C => 45,
MAX ( 230I => 30, 230L => 60 ),
(101E AND 184I) => 15,
(103R AND 179D) => 15,
(138K AND 184I) => 15,
(181C AND 190ACSTV) => 10,
(98G AND 181C) => 5,
MAX ((179F AND 181C) => 15, (179T AND 181C) => 10))]]>
ATV/r
atazanavir/r
5,
MAX ( 24F => 5, 24I => 10, 24M => 5 ),
32I => 15,
33F => 5,
MAX ( 46I => 10, 46L => 10, 46V => 10 ),
MAX ( 48A => 10, 48L => 10, 48M => 30, 48Q => 10, 48S => 10, 48T => 10, 48V => 30 ),
50L => 60,
53L => 10,
MAX ( 54A => 15, 54L => 15, 54M => 15, 54S => 15, 54T => 15, 54V => 15 ),
MAX ( 73A => 10, 73C => 10, 73D => 5, 73S => 10, 73T => 10, 73V => 5 ),
74P => 10,
MAX ( 82A => 15, 82C => 15, 82F => 15, 82L => 10, 82M => 10, 82S => 30, 82T => 30 ),
83D => 10,
MAX ( 84A => 60, 84C => 60, 84V => 60 ),
MAX ( 88D => 10, 88G => 15, 88S => 60, 88T => 15 ),
90M => 25,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 82ACFLMST) => 10,
(46ILV AND 90M) => 10,
(53L AND 90M) => 10,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 10,
(73ACSTV AND 90M) => 10,
(82ACFLMST AND 90M) => 10)]]>
DRV/r
darunavir/r
5,
32I => 15,
33F => 5,
MAX ( 47A => 10, 47V => 10 ),
MAX ( 50L => -10, 50V => 20 ),
MAX ( 54L => 20, 54M => 20 ),
74P => 5,
76V => 20,
82F => 15,
MAX ( 84A => 30, 84C => 15, 84V => 15 ),
88S => -5,
89V => 5,
(11IL AND 32I) => 5,
(11IL AND 54LM) => 5,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(32I AND 76V) => 5,
(32I AND 84V) => 5,
(32I AND 89V) => 5,
(47AV AND 54LM) => 5,
(47AV AND 84V) => 5,
(54LM AND 84V) => 5,
(54LM AND 89V) => 5)]]>
FPV/r
fosamprenavir/r
15,
20T => 5,
MAX ( 24F => 5, 24I => 10, 24M => 5 ),
32I => 30,
33F => 10,
MAX ( 46I => 10, 46L => 10, 46V => 10 ),
MAX ( 47A => 60, 47V => 35 ),
MAX ( 50L => -5, 50V => 60 ),
MAX ( 54A => 10, 54L => 60, 54M => 60, 54S => 10, 54T => 10, 54V => 10 ),
MAX ( 73A => 10, 73C => 10, 73D => 5, 73S => 10, 73T => 10, 73V => 5 ),
74P => 10,
76V => 60,
MAX ( 82A => 15, 82C => 15, 82F => 30, 82L => 15, 82M => 15, 82S => 15, 82T => 15 ),
MAX ( 84A => 60, 84C => 60, 84V => 60 ),
88S => -10,
89V => 10,
90M => 20,
(11IL AND 32I) => 5,
(11IL AND 54LM) => 5,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(32I AND 76V) => 5,
(32I AND 84V) => 5,
(32I AND 89V) => 5,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 76V) => 10,
(46ILV AND 82ACFLMST) => 10,
(46ILV AND 90M) => 10,
(47AV AND 54LM) => 5,
(47AV AND 84V) => 5,
(53L AND 90M) => 10,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 10,
(54LM AND 84V) => 5,
(54LM AND 89V) => 5,
(73ACSTV AND 90M) => 10,
(82ACFLMST AND 90M) => 10)]]>
IDV/r
indinavir/r
10,
20T => 5,
MAX ( 24F => 5, 24I => 15, 24M => 5 ),
32I => 15,
33F => 5,
MAX ( 46I => 10, 46L => 10, 46V => 10 ),
MAX ( 47A => 15, 47V => 15 ),
MAX ( 48A => 10, 48L => 10, 48M => 10, 48Q => 10, 48S => 10, 48T => 10, 48V => 10 ),
50L => -5,
MAX ( 54A => 15, 54L => 10, 54M => 15, 54S => 15, 54T => 15, 54V => 15 ),
MAX ( 73A => 15, 73C => 15, 73D => 5, 73S => 15, 73T => 15, 73V => 5 ),
74P => 10,
76V => 30,
MAX ( 82A => 30, 82C => 15, 82F => 30, 82L => 10, 82M => 30, 82S => 30, 82T => 30 ),
83D => 10,
MAX ( 84A => 60, 84C => 60, 84V => 60 ),
88S => 15,
89V => 5,
90M => 30,
(11IL AND 32I) => 5,
(11IL AND 54LM) => 5,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(32I AND 76V) => 5,
(32I AND 84V) => 5,
(32I AND 89V) => 5,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 76V) => 10,
(46ILV AND 82ACFLMST) => 10,
(46ILV AND 90M) => 10,
(47AV AND 54LM) => 5,
(47AV AND 84V) => 5,
(53L AND 90M) => 10,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 10,
(54LM AND 84V) => 5,
(54LM AND 89V) => 5,
(73ACSTV AND 90M) => 10,
(82ACFLMST AND 90M) => 10)]]>
LPV/r
lopinavir/r
5,
MAX ( 24F => 5, 24I => 10, 24M => 5 ),
32I => 15,
33F => 5,
MAX ( 46I => 10, 46L => 10, 46V => 5 ),
MAX ( 47A => 60, 47V => 15 ),
MAX ( 48A => 10, 48L => 10, 48M => 10, 48Q => 10, 48S => 10, 48T => 10, 48V => 10 ),
MAX ( 50L => -10, 50V => 30 ),
MAX ( 54A => 15, 54L => 20, 54M => 20, 54S => 15, 54T => 15, 54V => 15 ),
MAX ( 73A => 5, 73C => 5, 73D => 5, 73S => 5, 73T => 5, 73V => 5 ),
74P => 5,
76V => 30,
MAX ( 82A => 30, 82C => 15, 82F => 30, 82L => 10, 82M => 25, 82S => 30, 82T => 30 ),
MAX ( 84A => 60, 84C => 30, 84V => 30 ),
90M => 15,
(11IL AND 32I) => 5,
(11IL AND 54LM) => 5,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(32I AND 76V) => 5,
(32I AND 84V) => 5,
(32I AND 89V) => 5,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 76V) => 10,
(46ILV AND 82ACFLMST) => 10,
(47AV AND 54LM) => 5,
(47AV AND 84V) => 5,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 5,
(54LM AND 84V) => 5,
(54LM AND 89V) => 5,
(82ACFLMST AND 90M) => 5)]]>
NFV
nelfinavir
15,
20T => 15,
23I => 15,
MAX ( 24F => 10, 24I => 10, 24M => 10 ),
30N => 60,
32I => 15,
33F => 10,
43T => 10,
MAX ( 46I => 30, 46L => 20, 46V => 20 ),
MAX ( 47A => 30, 47V => 20 ),
MAX ( 48A => 30, 48L => 30, 48M => 30, 48Q => 30, 48S => 30, 48T => 30, 48V => 30 ),
50V => 15,
53L => 10,
MAX ( 54A => 20, 54L => 20, 54M => 20, 54S => 20, 54T => 20, 54V => 20 ),
58E => 10,
MAX ( 73A => 15, 73C => 15, 73D => 10, 73S => 15, 73T => 15, 73V => 10 ),
74P => 20,
76V => 10,
MAX ( 82A => 30, 82C => 30, 82F => 30, 82L => 10, 82M => 30, 82S => 30, 82T => 30 ),
83D => 15,
MAX ( 84A => 60, 84C => 60, 84V => 60 ),
MAX ( 88D => 60, 88G => 30, 88S => 60, 88T => 30 ),
89V => 10,
90M => 60,
(11IL AND 32I) => 5,
(11IL AND 54LM) => 5,
(32I AND 47AV) => 5,
(32I AND 54LM) => 5,
(32I AND 76V) => 5,
(32I AND 84V) => 5,
(32I AND 89V) => 5,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 76V) => 10,
(46ILV AND 82ACFLMST) => 10,
(46ILV AND 90M) => 10,
(47AV AND 54LM) => 5,
(47AV AND 84V) => 5,
(53L AND 90M) => 10,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 10,
(54LM AND 84V) => 5,
(54LM AND 89V) => 5,
(73ACSTV AND 90M) => 10,
(82ACFLMST AND 90M) => 10)]]>
SQV/r
saquinavir/r
5,
MAX ( 24F => 5, 24I => 10, 24M => 5 ),
33F => 5,
MAX ( 46I => 10, 46L => 10, 46V => 5 ),
MAX ( 48A => 60, 48L => 60, 48M => 60, 48Q => 60, 48S => 60, 48T => 60, 48V => 60 ),
MAX ( 50L => -5, 50V => 15 ),
53L => 15,
MAX ( 54A => 15, 54L => 15, 54M => 15, 54S => 15, 54T => 15, 54V => 15 ),
MAX ( 73A => 15, 73C => 15, 73D => 10, 73S => 15, 73T => 15, 73V => 10 ),
74P => 10,
MAX ( 82A => 15, 82C => 15, 82F => 10, 82L => 10, 82M => 15, 82S => 15, 82T => 15 ),
83D => 10,
MAX ( 84A => 60, 84C => 60, 84V => 60 ),
MAX ( 88D => 10, 88S => 15 ),
90M => 45,
(46IL AND 84V AND 90M) => 5,
(46ILV AND 82ACFLMST) => 10,
(46ILV AND 90M) => 5,
(53L AND 90M) => 10,
(54ALMSTV AND 82ACFLMST) => 10,
(54ALMSTV AND 90M) => 10,
(73ACSTV AND 90M) => 10,
(82ACFLMST AND 90M) => 10)]]>
TPV/r
tipranavir/r
-5,
32I => 5,
33F => 10,
43T => 10,
MAX ( 46I => 5, 46L => 10, 46V => 5 ),
MAX ( 47A => 30, 47V => 30 ),
MAX ( 50L => -5, 50V => -5 ),
MAX ( 54A => 20, 54L => -10, 54M => 20, 54S => 20, 54T => 20, 54V => 20 ),
58E => 15,
74P => 25,
76V => -5,
MAX ( 82C => 10, 82L => 45, 82M => 10, 82S => 30, 82T => 45 ),
83D => 25,
MAX ( 84A => 60, 84C => 30, 84V => 30 ),
(46IL AND 84V AND 90M) => 5)]]>
DTG
dolutegravir
5,
66K => 15,
92Q => 10,
118R => 15,
121Y => 10,
MAX ( 138A => 10, 138K => 10, 138T => 10 ),
MAX ( 140A => 10, 140C => 10, 140S => 10 ),
MAX ( 143A => 5, 143C => 5, 143G => 5, 143H => 5, 143K => 5, 143R => 5, 143S => 5 ),
MAX ( 148H => 25, 148K => 30, 148R => 25 ),
151L => 15,
MAX ( 153F => 15, 153Y => 15 ),
155H => 10,
263K => 15,
(138AKT AND 140ACS) => 10,
(138AKT AND 148HKR) => 10,
(140ACS AND 148HKR) => 10,
(143ACGHRS AND 163R) => 5,
(143ACGHRS AND 230R) => 5,
(148HKR AND 155H) => 5,
(148HKR AND 163KR) => 5,
(157Q AND 263K) => 10,
(51Y AND 263K) => 10,
(74IM AND 143ACGHRS) => 5,
(74IM AND 148HKR) => 5,
(92Q AND 155H) => 5,
(97A AND 148HKR) => 5)]]>
EVG
elvitegravir
15,
MAX ( 66A => 60, 66I => 60, 66K => 60 ),
MAX ( 92G => 30, 92Q => 60, 92V => 60 ),
95K => 10,
97A => 10,
118R => 30,
121Y => 60,
MAX ( 138A => 15, 138K => 15, 138T => 15 ),
MAX ( 140A => 30, 140C => 30, 140S => 30 ),
MAX ( 143A => 10, 143C => 10, 143G => 10, 143H => 10, 143K => 10, 143R => 10, 143S => 10 ),
145S => 60,
146P => 60,
147G => 60,
MAX ( 148H => 60, 148K => 60, 148N => 15, 148R => 60 ),
MAX ( 151A => 30, 151L => 60 ),
MAX ( 153F => 15, 153Y => 15 ),
MAX ( 155H => 60, 155S => 30, 155T => 30 ),
157Q => 10,
MAX ( 163K => 10, 163R => 10 ),
230R => 15,
263K => 30,
(138AKT AND 140ACS) => 15,
(143ACGHRS AND 163R) => 5,
(143ACGHRS AND 230R) => 5,
(51Y AND 263K) => 15,
(74IM AND 143ACGHRS) => 5,
(97A AND 143ACGHRS) => 5)]]>
RAL
raltegravir
15,
MAX ( 66A => 15, 66I => 15, 66K => 60 ),
MAX ( 92G => 15, 92Q => 30, 92V => 30 ),
95K => 10,
97A => 10,
118R => 30,
121Y => 60,
MAX ( 138A => 15, 138K => 15, 138T => 15 ),
MAX ( 140A => 30, 140C => 30, 140S => 30 ),
MAX ( 143A => 60, 143C => 60, 143G => 60, 143H => 60, 143K => 60, 143R => 60, 143S => 60 ),
MAX ( 148H => 60, 148K => 60, 148N => 10, 148R => 60 ),
MAX ( 151A => 15, 151L => 30 ),
MAX ( 155H => 60, 155S => 30, 155T => 30 ),
157Q => 10,
MAX ( 163K => 10, 163R => 10 ),
230R => 15,
263K => 15,
(138AKT AND 140ACS) => 15)]]>
RT
40F
41L
41I
44AD
62V
65R
65N
65E
65ACDFGHILMPQSTVWYid
67N
67GESTH
67d
67ACFIKLMPQRVWYi
68d
69d
69i
69D
69G
69N
69SAIE
69CFHKLMPQRVWY
70R
70EG
70QNST
70d
70ACDFHILMPVWYi
74VI
74ACDEFGHKMNPQRSTWYid
75I
75T
75M
75SA
75CDEFGHKNPQRWYid
77L
77ACDEGHIKMNPQRSTVWYid
115F
115ACDEGHIKLMNPQRSTVWid
116Y
116ACDEGHIKLMNPQRSTVWid
118I
151M
151L
151ACDEFGHIKNPRSTVWYid
184VI
184ACDEFGHKLNPQRSTWYid
210W
215Y
215F
215SCDEIVALN
215GHKMPQRWid
219QE
219NR
219W
219ACDFGHILMPSTVYid
90I
98G
100I
100V
100ACDEFGHKMNPQRSTWYid
101P
101E
101H
101NAT
101Q
101CDFGILMSVWYid
103N
103S
103T
103H
103R
103EQ
103ACDFGILMPVWYid
106A
106M
106I
106CDEFGHKLNPQRSTWYid
108I
108ACDEFGHKLMNPQRSTWYid
132ML
138K
138QG
138A
138R
138CDFHILMNPSTVWYid
179DE
179F
179T
179L
179I
179ACGHKMNPQRSWYid
181C
181IV
181FSG
181ADEHKLMNPQRTWid
188C
188H
188L
188F
188ADEGIKMNPQRSTVWid
190A
190S
190EQ
190CTV
190DFHIKLMNPRWYid
221Y
225H
225ACDEFGIKLMNQRSTVWYid
227C
227L
227ADEGHIKMNPQRSTVWYid
230L
230I
230ACDEFGHKNPQRSTVWYid
236L
236ACDEFGHIKMNQRSTVWYid
238TN
238R
238ACDEFGHILMPQSVWYid
318F
318ACDEGHIKLMNPQRSTVWid
348I
348ACDEFGHKLMPQRSTVWYid
PR
10F
10IV
10RY
10ACDEGHKMNPQSTWid
11IL
20T
20MV
20I
20R
23I
24I
24FM
24ACDEGHKNPQRSTVWYid
30N
30ACEFGHIKLMPQRSTVWYid
32I
32ACDEFGHKLMNPQRSTWYid
33F
43T
46IL
46V
46ACDEFGHKNPQRSTWYid
47V
47A
47CDEFGHKLMNPQRSTWYid
48V
48M
48ASTQL
48CDEFHIKNPRWYid
50L
50V
50ACDEFGHKMNPQRSTWYid
53L
53Y
54V
54ATS
54LM
54CDEFGHKNPQRWYid
58E
71TV
71IL
73STCADV
73EFHIKLMNPQRWYid
74P
74S
76V
76ACDEFGHIKMNPQRSTWYid
82A
82TS
82F
82M
82L
82C
82I
82DEGHKNPQRWYid
83D
84V
84AC
84DEFGHKLMNPQRSTWYid
85V
88D
88S
88TG
88ACEFHIKLMPQRVWYid
89VT
90M
90ACDEFGHIKNPQRSTVWYid
IN
51Y
51ACDEFGIKLMNPQRSTVWid
66I
66K
66A
66CDEFGHLMNPQRSVWYid
74MI
92Q
92V
92G
92ACDFHIKLMNPRSTWYid
95K
97A
118R
118ACDEFHIKLMNPQSTVWYid
121Y
121ACDEGHIKLMNPQRSTVWid
128T
138KAT
138D
138CFGHILMNPQRSVWYid
140SAC
140DEFHIKLMNPQRTVWYid
143CR
143H
143KGSA
143DEFILMNPQTVWid
145S
145ACDEFGHIKLMNQRTVWYid
146P
146ACDEFGHIKLMNRSTVWYid
147G
147ACDEFHIKLMNPQRTVWYid
148HKR
148N
148ACDEFGILMPSTVWYid
151I
151A
151L
151CDEFGHKMNPQRSTWYid
153YF
153ACDEGHIKLMNPQRTVWid
155H
155ST
155ACDEFGIKLMPQRVWYid
157Q
163RK
230R
230N
263K
263ACDEFGHILMNPQSTVWYid