| Time-point | Gene | Mutations |
|---|
| 1 | PR | 14R, 15V, 37D, 63A, 77I, 93L |
| 1 | RT | 41L, 60I, 135T |
| 2 | PR | 14RK, 15VI, 37D, 46I, 62V, 63A, 77I, 88S, 93L |
| 2 | RT | 60IV, 135T, 211K |
| 3 | PR | 14R, 15V, 37D, 63A, 77I, 93L |
| 3 | RT | 10AV, 16LM, 41L, 43TK, 60I, 64RK, 103N, 135T, 211K, 215Y, 243SP, 245L*EV |
