| Time-point | Gene | Mutations |
|---|
| 1 | PR | 10I, 13V, 14RK, 36I, 37D, 48V, 63P, 71TA, 74S, 82A |
| 1 | RT | 35T, 39A, 41L, 43EK, 44DE, 60I, 67N, 69D, 75M, 77L, 82R, 118I, 122E, 135T, 138K, 184V, 208YH, 210W, 215Y |
| 2 | PR | 10I, 13V, 35D, 36I, 37D, 48V, 63P, 71V, 74S, 82A, 84V |
| 2 | RT | 35T, 39A, 41L, 44DE, 60I, 67N, 69D, 75M, 77L, 118I, 122E, 135T, 138K, 162SDGN, 184V, 208YH, 210W, 211KR, 215Y |
| 3 | PR | 10I, 13V, 14RK, 19IL, 20MK, 35D, 36I, 37D, 48V, 63P, 64VI, 71VA, 74S, 75IV, 82A, 84V |
| 3 | RT | 35T, 39A, 41L, 44DE, 60I, 67N, 69D, 75M, 77L, 101QK, 118IV, 122E, 135T, 138K, 162NDGS, 184V, 208YH, 210W, 211KR, 215Y, 223QK, 245EV |
| 4 | PR | 6*W, 10I, 11I, 13V, 14R, 22V, 35D, 36I, 37D, 48M, 53L, 62V, 63P, 71V, 74S, 82A, 84V, 91S, 92K |
| 4 | RT | 35T, 39E, 41L, 44D, 60I, 67N, 69D, 75M, 77L, 118I, 122E, 123N, 135T, 138K, 184V, 208Y, 210W, 211K, 215Y |
| 5 | PR | 10I, 11L, 13V, 14RK, 22V, 35D, 36I, 37D, 48M, 53L, 54V, 62V, 63P, 71V, 74S, 82A, 84V, 91S, 92K |
| 5 | RT | 35T, 39E, 41L, 44D, 60I, 67N, 69D, 75M, 77L, 118I, 122E, 123N, 135T, 138K, 162X, 184V, 208Y, 210W, 211K, 215Y, 245EV |
