HBV RT Mutation Prevalence According to Genotype and Treatment

HBV RT: Mutation prevalence according to genotype and treatment

A detailed description of this page as well as all other pages (and programs) on the HBV site can be found in the Release Notes; Each mutation in the table below is hyperlinked to a web page with information about the sequences containing the mutation. Abbreviation: N(t)RTI - nucleos(t)ide RT inhibitors; L-nuc. - L-nucleoside analogs (lamivudine, emtricitabine, telbivudine); ETV - entecavir; ANPs - acyclic nucleoside phosphonates (adefovir, tenofovir)

Pos	N(t)RTI Naive Persons (by Genotype)										N(t)RTI Treated Persons (by Treatment)
Pos	A 506	B 552	C 734	D 887	E 311	F 132	G 22	H 27	I 52	pooled 3216	L-Nuc. and/or ETV 458	ANPs 90	L-Nuc. and/or ETV + ANPs 191
1	E D^1.4	E D^7.2 Q^0.3 K^0.3	E D^0.5	E	E D^0.7 Q^0.4	E D^5.5	Q E^5.6	E	E K^2.1	E Q D^1.6 K^0.1	E Q D^1.2 K^0.8	E Q D^2.0	E Q D^2.5
2	D N^0.2	D N^0.3	D G^0.2 E^0.2	D E^0.1	D	D N^1.1	D	D	D	D N^0.1 E^0.1 G^0.0	D	D	D N^0.8
3	W R^0.2	W	W C^0.2	W	W	W	W	W	W	W C^0.0 R^0.0	W	W	W
4	G	G	G C^0.2 R^0.2	G	G	G	G	G	G	G C^0.0 R^0.0	G	G	G
5	P	P	P	P	P	P	P	P	P	P	P	P	P L^0.8
6	C	C	C R^0.2	C W^0.1	C	C	C	C	C	C W^0.0 R^0.0	C A^0.4 V^0.4	C	C
7	D A^17.8 V^12.5 T^10.6 G^4.3 E^1.4 N^0.5 Y^0.5 F^0.2 S^0.2 H^0.2	T A^19.0 S^1.4 D^0.5 N^0.3	T A^4.4 I^0.8 N^0.6 S^0.3 Q^0.3	A T^4.3 V^2.2 D^1.4 S^0.4 G^0.3 P^0.1	T S^0.7	Y H^18.7 N^1.1 I^1.1	T D^5.6	Y	T N^52.1 S^4.2 H^2.1 Y^2.1	T Y A D V^2.6 N^1.2 H^0.7 G^0.7 S^0.6 E^0.2 I^0.2 Q^0.1 F^0.0 P^0.0	T Y A D F^5.5 V^1.2 S^0.4 E^0.4	T Y A D S^2.0	T Y A D E^0.8 V^0.8
8	E D^9.0 K^0.5 A^0.2 Q^0.2	E	E H^0.3	E Q^0.3 D^0.1	E	E	E	E	E	E D^1.4 H^0.1 Q^0.1 K^0.1 A^0.0	E D^4.9 N^0.4	E	E Q^0.8 D^0.8
9	H Y^0.7 Q^0.5	H Y^0.8 D^0.3 N^0.3	H Y^22.2 N^1.1 D^0.5	H Y^0.8 N^0.5 L^0.1	H Y^0.4	H	H Y^5.6	H	H Y^6.2	H Y^6.1 N^0.4 Q^0.1 D^0.1 L^0.0	H Y^5.3 D^0.4 N^0.4	H Y^4.1	H Y^4.2 N^0.8
10	G R^0.2	G	G A^0.1	G	G	G	G	G	G	G A^0.0 R^0.0	G	G	G
11	E Q^0.5 K^0.2	E D^0.3	E Q^0.4 H^0.3 D^0.3 K^0.3	E K^0.9	K R^8.9 E^1.0 N^0.7 Q^0.3 T^0.3	Q E^30.8	E	E	E K^5.8	E Q K R^1.0 H^0.1 D^0.1 N^0.1 T^0.0	E Q K	E Q K	E Q K D^1.7 R^0.8
12	H R^0.5 Q^0.2	H Q^0.5	H N^0.1	H	H	H	H Y^5.6	H	H	H Q^0.1 R^0.1 N^0.0 Y^0.0	H N^0.4	H	H
13	H Y^0.7 N^0.2	R H^3.7 L^2.2 S^0.3 N^0.3	N H^23.3 S^3.6 R^1.7 Y^0.6 L^0.5 F^0.3	H N^0.4 Y^0.4 P^0.1 L^0.1	H Y^1.3	H Y^22.0	H	H	H Y^1.9	H N R Y^1.3 S^0.9 L^0.4 F^0.1 P^0.0	H N R S^0.8 D^0.4 L^0.4	H N R S^6.4	H N R S^0.8 C^0.8 L^0.8
14	I	I V^0.3	I	I V^0.1	I V^1.0	I V^1.1	I	I	I	I V^0.2	I	I	I
15	R K^0.2 E^0.2	R T^0.3 K^0.3	R	R T^0.1 K^0.1	R K^2.3 T^0.3	R	R	R	R	R K^0.4 T^0.1 E^0.0	R K^1.5	R	R
16	I T^3.3 S^0.2	T I^0.8	I T^1.1	I T^5.9 L^0.1	I T^1.0	T	I	T	I T^1.9	I T S^0.0 L^0.0	I T V^0.4	I T	I T
17	P	P H^0.3	P	P	P	P	P	P	P	P H^0.0	P	P	P
18	R K^2.1	R K^1.1 T^0.3	R K^0.6	R G^0.5 S^0.1	R M^0.3 K^0.3 G^0.3	R	R	R K^3.7	R	R K^0.7 G^0.2 S^0.0 M^0.0 T^0.0	R K^0.8 S^0.4	R K^2.1	R S^0.8
19	T A^0.2	T	T S^0.1	T	T	T	T	T	T	T A^0.0 S^0.0	T	T	T
20	P	P	P N^0.3 S^0.1	P	P	P	P	P	P	P N^0.1 S^0.0	P	P	P
21	A S^0.5 T^0.5	A S^0.3 G^0.3	A S^0.4 G^0.1	A S^13.6 T^1.1	A	A	A	S	A T^1.9	A S T^0.4 G^0.1	A S	A S T^2.0	A S
22	R	R	R	R	R C^0.3	R	R	R	R	R C^0.0	R	R	R
23	V I^0.2	V I^0.8	V I^1.3	V I^0.4	V I^0.7	V	V	V	V I^27.5	V I^1.2	V I^0.4	V I^2.0	V
24	T	T P^0.3	T	T S^0.1	T	T	T	T	T	T S^0.0 P^0.0	T A^0.4	T	T
25	G	G	G D^0.1	G	G	G	G	G	G	G D^0.0	G	G	G
26	G R^0.2	G E^0.3	G	G R^0.1	G	G	G	G	G	G R^0.1 E^0.0	G	G	G E^0.8
27	V del^0.2 I^0.2	V I^0.8	V	V	V I^3.3	V G^1.1	V	V	I V^53.8	V I del^0.0 G^0.0	V I A^1.1	V I	V I
28	F L^0.2	F L^0.3	F	F S^0.1	F	F	F	F	F	F L^0.1 S^0.0	F	F	F
29	L S^0.2	L	L	L F^0.5	L F^0.3	L	L	L	L	L F^0.2 S^0.0	L I^0.4	L	L
30	V	V I^0.3	V	V	V	V	V	V	V	V I^0.0	V	V	V
31	D N^0.2	D	D N^0.1 E^0.1	D N^0.2	D	D	D	D	D N^1.9	D N^0.2 E^0.0	D	D	D
32	K	K Q^0.5	K R^0.3	K	K N^0.3	K	K	K	K	K Q^0.1 R^0.1 N^0.0	K	K	K
33	N	N S^0.3	N S^0.1	N D^0.1	N H^0.3	N	N	N	N K^1.9	N S^0.1 H^0.0 D^0.0 K^0.0	N	N	N
34	P	P	P L^0.1	P L^0.2 H^0.1	P H^0.3	P	P	P	P	P H^0.1 L^0.1	P	P	P
35	H	H	H R^0.3 Q^0.1 N^0.1 L^0.1 Y^0.1	H Q^0.9 N^0.1	H Q^0.3	H Q^1.1	H	H	H	H Q^0.4 N^0.1 R^0.1 L^0.0 Y^0.0	H	H	H
36	N	N	N	N H^0.1 K^0.1	N	N	N	N	N	N H^0.0 K^0.0	N	N	N
37	T P^0.2	T S^0.3	T A^0.3 S^0.1 P^0.1	T A^0.2 S^0.1	T S^1.0	T A^1.1 S^1.1	T	T	T	T S^0.3 A^0.2 P^0.1	T	T	T
38	A T^2.6 S^0.5 E^0.5	T A^6.8 S^0.5	T A^5.1 K^0.8 S^0.5 P^0.2	A E^4.6 K^3.4 T^0.5 S^0.4	A T^0.7 E^0.7	T K^1.1 E^1.1	A	T K^29.6	A T^3.8	A T K^1.5 E^1.5 S^0.4 P^0.0	A T E^4.9 K^1.1	A T E^2.1	A T
39	E K^0.2	E A^0.3 K^0.3	E	E K^0.2	E	E	E	E	E	E K^0.1 A^0.0	E	E	E
40	S F^0.2	S	S A^0.3	S	S T^0.3	S A^1.6	S	S	S	S A^0.1 F^0.0 T^0.0	S A^0.7	S	S A^0.8
41	R	R K^0.5	R K^0.4 T^0.1	R	R I^0.3	R	R	R	R	R K^0.2 T^0.0 I^0.0	R I^0.4	R	R
42	L	L	L	L	L	L	L	L	L	L	L	L	L
43	V	V	V M^0.1 G^0.1	V	V E^0.3	V	V	V	V	V M^0.0 G^0.0 E^0.0	V A^0.4	V	V E^0.8
44	V	V	V del^0.1 E^0.1	V A^0.1	V	V	V	V	V	V A^0.0 del^0.0 E^0.0	V	V	V
45	D	D A^0.3	D	D	D	D	D	D	D	D A^0.0	D	D	D
46	F	F	F	F	F	F	F	F	F	F	F	F	F
47	S	S	S P^0.1	S	S C^0.3	S	S	S	S	S C^0.0 P^0.0	S	S	S
48	Q	Q R^0.3	Q	Q	Q	Q	Q	Q	Q	Q R^0.0	Q	Q	Q
49	F	F	F	F S^0.1	F Y^0.3	F	F	F	F	F S^0.0 Y^0.0	F	F	F
50	S P^0.7	S	S P^0.1 L^0.1	S	S C^1.3	S	S	S	S	S C^0.1 P^0.1 L^0.0	S Y^0.3	S	S
51	R	R K^0.5	R G^0.3 K^0.1	R	R K^0.3	R	R	R	R K^1.9	R K^0.2 G^0.1	R	R	R
52	G	G A^0.3	G	G	G R^0.3	G	G	G	G	G A^0.0 R^0.0	G	G	G
53	I V^14.5 L^13.3 S^6.1 T^3.3 A^1.6 N^1.2 P^0.9 F^0.2 H^0.2	N D^3.5 H^1.9 T^1.6 S^0.8 K^0.5 Q^0.3 P^0.3 E^0.3	S N^3.9	N D^5.0 K^2.6 S^1.0 E^0.4 H^0.2 T^0.1 I^0.1	S I^2.0 N^1.6 G^0.3	T N^29.5 S^0.8 P^0.8	S	T	I S^58.8 N^2.0	S T N I V^2.2 L^2.0 D^1.9 K^0.8 H^0.4 A^0.3 P^0.2 E^0.1 F^0.0 Q^0.0 G^0.0	S T N I L^4.5 V^3.5 D^1.0 K^1.0 P^0.7 H^0.3 E^0.3	S T N I	S T N I V^1.4 A^0.7 E^0.7
54	T S^6.1 N^1.8	T N^1.8 A^0.5 S^0.5 P^0.3	T Y^2.8 S^1.3 H^0.3 N^0.3 P^0.1	Y H^26.0 N^1.0 D^0.9 T^0.6 P^0.3 C^0.1 R^0.1	S T^1.0	T N^0.8	A	T	N T^56.9	T A S N Y H^7.4 D^0.2 P^0.1 C^0.0 R^0.0	T A S N Y H^8.9 D^1.0	T A S N Y H^2.0	T A S N Y H^7.6
55	R S^0.2	R H^0.3	H R^6.3 Q^6.2 K^2.6 S^0.5 D^0.2 N^0.2	R K^0.1	R	R Q^0.8	R	R	R H^2.0	R H Q^1.5 K^0.6 S^0.1 D^0.0 N^0.0	R H Q^1.3 K^0.7	R H	R H A^0.7 Q^0.7
56	V	V	V	V	V M^0.3	V	V	V	V	V M^0.0	V	V	V M^0.7
57	S P^0.2	S P^0.3	S F^0.3 Y^0.1	S P^0.5	S	S F^0.8	S	S	S P^5.8	S P^0.3 F^0.1 Y^0.0	S C^0.3	S	S P^0.6
58	W	W	W C^0.3 L^0.1	W C^0.1	W	W	W	W	W	W C^0.1 L^0.0	W	W	W
59	P	P	P A^0.1	P T^0.1	P A^0.3	P	P	P	P	P A^0.1 T^0.0	P	P	P
60	K	K	K	K T^0.1 R^0.1	K	K	K	K	K	K T^0.0 R^0.0	K R^0.3	K	K
61	F	F	F	F I^0.1	F	F	F	F	F I^1.9	F I^0.1	F C^0.3 Y^0.3	F	F
62	A	A P^0.3	A	A	A	A	A	A	A	A P^0.0	A	A	A
63	V I^0.2	V L^0.3	V	V	V	V	V	V	V	V I^0.0 L^0.0	V	V	V
64	P	P	P T^0.1	P	P	P	P	P	P	P T^0.0	P	P	P
65	N	N	N	N D^0.1	N	N	N	N	N	N D^0.0	N	N	N
66	L	L	L P^0.1	L	L	L	L	L	L	L P^0.0	L	L	L
67	Q	Q	Q	Q	Q	Q	Q	Q	Q	Q	Q	Q P^1.7	Q
68	S	S	S	S A^0.1	S	S	S	S	S	S A^0.0	S A^0.3	S	S
69	L	L	L	L	L I^0.3	L	L	L	L	L I^0.0	L	L	L
70	T	T	T	T	T	T	T	T	T	T	T	T	T
71	N	N	N	N	N	N	N	N	N K^1.9	N K^0.0	N	N	N D^0.6
72	L	L	L	L	L	L	L	L	L H^1.9	L H^0.0	L	L	L
73	L F^0.2 P^0.2	L	L W^0.1	L	L	L	L	L	L	L F^0.0 W^0.0 P^0.0	L	L	L
74	S	S	S	S	S	S	S	S	S	S	S	S	S
75	S A^0.2	S T^0.5	S T^1.0 P^0.1	S	S T^0.3	S	S	S	S A^1.9	S T^0.3 A^0.1 P^0.0	S	S	S
76	N D^0.9 K^0.2	N D^20.8	N D^1.8 K^0.1	N D^4.0 S^0.5 G^0.1	N D^1.6 H^0.3	N	N	N	N D^1.9	N D^4.7 S^0.1 K^0.1 H^0.0 G^0.0	N D^3.3	N D^6.9	N D^1.9
77	L M^0.2	L	L F^0.1	L	L	L	L	L	L	L F^0.0 M^0.0	L W^0.3	L	L
78	S	S P^0.3	S T^0.6	S T^0.8 A^0.4 C^0.4	S A^0.3	S	S	S	S	S T^0.4 A^0.1 C^0.1 P^0.0	S T^0.7	S T^3.4	S T^2.5
79	W	W	W R^0.1	W	W	W	W	W	W	W R^0.0	W	W	W
80	L V^0.2	L	L V^0.6	L I^0.2	L Q^0.3	L	L	L	L V^1.9	L V^0.2 I^0.1 Q^0.0	L I^10.4 V^2.9	L	L I^6.4 V^1.3
81	S	S	S	S A^0.1	S	S	S	S	S	S A^0.0	S	S	S
82	L R^0.4	L	L	L	L	L	L	L S^7.4	L	L S^0.1 R^0.1	L M^1.0	L	L M^1.9
83	D	D	D	D	D	D	D	D	D	D	D	D	D
84	V A^0.2 M^0.2	V	V I^0.4	V A^0.2	V	V	V	V	V	V A^0.1 I^0.1 M^0.0	V	V	V
85	S	S T^0.3	S T^0.6 F^0.1 P^0.1	S C^0.2 A^0.1	S P^0.3	S	S	S	S	S T^0.2 C^0.1 P^0.1 A^0.0 F^0.0	S A^0.3	S A^1.7	S A^1.9
86	A	A	A	A	A	A	A	A	A	A	A S^0.6	A	A
87	A R^0.2	A	A	A	A	A	A	A	A	A R^0.0	A	A E^1.7	A
88	F	F	F L^0.1	F R^0.1 V^0.1	F L^0.3 Y^0.3	F	F	F	F S^1.9	F L^0.1 S^0.0 R^0.0 Y^0.0 V^0.0	F	F	F
89	Y C^0.2	Y	Y	Y H^0.1 N^0.1	Y F^0.3	Y	Y	Y	Y	Y F^0.0 H^0.0 C^0.0 N^0.0	Y	Y	Y
90	H	H	H	H D^0.1	H	H	H	H	H	H D^0.0	H Y^0.6	H	H
91	I L^0.2	L I^4.5	I L^20.6 T^0.1	L I^6.9	L I^7.2	L I^1.5	I	L	L I^1.9	L I T^0.0	L I	L I	L I
92	P	P	P	P T^0.1	P	P	P	P	P	P T^0.0	P	P	P
93	L	L M^0.3	L	L	L	L	L	L	L	L M^0.0	L	L	L
94	H	H	H	H R^0.2 P^0.1	H	H	H	H	H	H R^0.1 P^0.0	H Y^0.3	H	H
95	P	P	P A^0.1	P L^0.1	P	P H^0.8	P	P	P	P A^0.0 H^0.0 L^0.0	P	P	P
96	A T^0.2	A	A	A	A	A	A	A	A	A T^0.0	A S^0.3 V^0.3	A	A
97	A	A	A S^0.4	A T^0.2 S^0.1	A V^0.3	A G^0.8	A	A	A T^1.9	A S^0.1 T^0.1 G^0.0 V^0.0	A T^0.3	A	A S^0.5
98	M	M I^0.4	M	M	M	M	M	M R^7.4	M	M I^0.1 R^0.1	M	M L^1.2	M
99	P	P	P	P	P	P	P	P	P	P	P	P	P
100	H	H	H P^0.3 D^0.1 R^0.1	H	H	H	H	H S^3.7	H	H P^0.1 S^0.0 D^0.0 R^0.0	H	H	H
101	L	L P^0.2	L F^0.1 P^0.1	L	L	L	L	L P^3.7	L	L P^0.1 F^0.0	L	L	L
102	L	L	L	L	L	L	L	L F^3.7	L	L F^0.0	L	L	L
103	I V^2.1	V A^0.2 I^0.2	V G^0.3 I^0.1	V	V D^0.3	V	V	V A^3.7	V I^1.9	V I A^0.1 G^0.1 D^0.0	V I	V I	V I
104	G	G	G C^0.1	G	G	G	G	G C^3.7	G	G C^0.1	G	G	G
105	S T^1.1 F^0.2	S C^0.2	S T^0.1	S	S P^0.3	S	S	S V^3.7	S	S T^0.2 F^0.0 C^0.0 P^0.0 V^0.0	S T^0.8	S	S
106	S C^0.2	S C^0.2	S C^2.5 A^0.4 P^0.1	S A^0.7 T^0.7 C^0.1	S	S C^3.1	S	S	S	S C^0.8 A^0.3 T^0.2 P^0.0	S A^2.0 C^0.5 T^0.3	S	S C^3.7
107	G	G	G	G	G	G	G	G	G	G	G	G	G
108	L F^0.2	L	L	L	L	L	L	L	L	L F^0.0	L	L	L
109	S P^12.3 Q^0.4	S P^0.9 Q^0.2	P S^10.2 Q^1.1	S P^1.1	S	S P^11.4	S	S	S	S P Q^0.3	S P Q^1.0	S P	S P
110	R G^3.6 K^0.2	R G^0.5 S^0.2	R K^0.1 G^0.1	R G^2.8	R G^1.6	R G^3.8	R	R	R G^3.8	R G^1.8 K^0.1 S^0.0	R G^4.3	R G^3.5	R G^1.6
111	Y	Y D^0.2	Y H^0.1 D^0.1	Y	Y N^0.3	Y	Y	Y	Y	Y D^0.1 H^0.0 N^0.0	Y	Y	Y
112	V F^0.6 I^0.6 L^0.2	V I^0.4	V I^0.1	V I^0.3 A^0.2 L^0.1	V L^1.0 I^0.3	V I^0.8	V	V	V	V I^0.3 L^0.2 A^0.1 F^0.1	V I^1.5	V	V
113	A	A S^0.4 G^0.4 T^0.2	A S^0.1 V^0.1	A T^0.1	A	A	A	A	A	A S^0.1 T^0.1 G^0.1 V^0.0	A S^0.2 T^0.2	A	A
114	R	R	R C^0.1	R C^0.2	R	R	R	R	R	R C^0.1	R	R	R
115	L	L V^0.2	L V^0.3 W^0.1	L V^3.2 M^0.6	L V^0.6	L	L	V M^3.7	L	L V M^0.2 W^0.0	L V M^0.5	L V M^1.2	L V
116	S	S	S	S P^0.3 A^0.1	S Y^0.3	S	S	S	S	S P^0.1 A^0.0 Y^0.0	S	S P^1.2	S
117	S Y^0.4 T^0.2	S P^0.7 Y^0.4 F^0.2 H^0.2	S	S Y^3.0 P^0.3 C^0.2	S P^0.3 Y^0.3	S C^0.8	S P^4.5	S	S	S Y^1.0 P^0.3 C^0.1 F^0.0 H^0.0 T^0.0	S P^0.5 A^0.3 Y^0.3	S P^1.2	S Y^0.5
118	N T^0.6 H^0.2 D^0.2	N D^2.6 T^2.0 H^1.5 A^0.2	T N^4.3 A^0.8 S^0.3 D^0.1	N D^6.6 T^0.7 H^0.1	N T^3.9 D^0.6	T N^14.5 A^0.8	D	T	N T^3.8 D^1.9	N T D A^0.3 H^0.3 S^0.1	N T D A^0.3	N T D	N T D H^0.5
119	S A^0.2 C^0.2 P^0.2 Y^0.2	S A^0.2 T^0.2	S T^0.1 K^0.1	S F^0.3 A^0.1	S P^0.6	S	S F^22.7	S	S	S F^0.3 A^0.1 T^0.1 P^0.1 C^0.0 K^0.0 Y^0.0	S N^0.2	S	S T^0.5
120	R Q^0.4 S^0.2 K^0.2	R G^0.2	R K^0.3 N^0.1 G^0.1 Y^0.1	R G^0.9	R	R	R	R	R	R G^0.3 Q^0.1 K^0.1 S^0.0 N^0.0 Y^0.0	R S^0.7 G^0.5 K^0.2	R	R
121	I N^0.8 S^0.2 T^0.2 L^0.2	I N^0.5	N I^3.6 D^0.3 K^0.3 S^0.1 R^0.1	I S^0.1 N^0.1	I N^4.2	I	I	I	I N^1.9	I N S^0.1 D^0.1 K^0.1 T^0.0 R^0.0 L^0.0	I N	I N	I N
122	N H^41.0 Y^0.8 L^0.4 D^0.2 K^0.2	I N^0.7 L^0.7 F^0.5 V^0.5 S^0.4 T^0.2	I F^3.3 N^1.8 L^1.4 V^0.7 T^0.3 Y^0.1 H^0.1 del^0.1	F L^14.4 I^5.6 V^3.8 H^0.2 S^0.2 N^0.2 D^0.1	I L^5.2 S^0.3 T^0.3 N^0.3	H Y^19.7 N^0.8	L	Y N^7.7 F^3.8	L H^1.9 I^1.9	I L H F N Y V^1.3 S^0.2 T^0.1 D^0.1 del^0.0 K^0.0	I L H F N Y V^1.5 D^0.3 R^0.3	I L H F N Y V^1.2	I L H F N Y V^1.1
123	N H^0.2 Y^0.2	N D^2.6 H^0.9 S^0.2	N H^3.3 D^0.4 del^0.1 Y^0.1	N D^3.7 H^0.1 E^0.1	N D^1.0 K^0.6	D N^7.6 H^0.8	D	N D^3.7	D N^3.8	N D H^1.0 K^0.1 Y^0.1 S^0.0 del^0.0 E^0.0	N D H^1.8 K^0.5	N D	N D K^0.5
124	N H^6.7 D^1.0 T^0.2 K^0.2	H N^33.2 D^3.1 Y^0.2	Y H^9.5 N^3.7 S^0.1 C^0.1 D^0.1 K^0.1	H Y^9.6 N^1.6 D^0.3 P^0.2	H N^0.3 K^0.3 Y^0.3	H Y^0.8	H	H	H N^1.9 Y^1.9	H N Y D^0.8 K^0.1 P^0.1 S^0.0 T^0.0 C^0.0	H N Y D^1.5 Q^0.3	H N Y	H N Y D^1.1
125	Q E^3.2 S^0.2 K^0.2 R^0.2	Q K^0.5 H^0.2	Q K^3.3 H^1.8 N^1.8	Q K^0.5	Q R^0.6 H^0.3	Q	Q	Q	Q H^1.9 N^1.9	Q K^1.0 H^0.5 E^0.5 N^0.4 R^0.1 S^0.0	Q H^0.2 K^0.2	Q	Q
126	Y H^7.9 T^0.2 C^0.2	H Y^0.2	H Y^3.7 N^0.3	H R^15.8 Q^0.3 Y^0.3 C^0.1 L^0.1	Y H^1.6 N^0.6 C^0.3	H	Y	H	Y H^9.8 R^2.0	H Y R^4.4 Q^0.1 C^0.1 N^0.1 T^0.0 L^0.0	H Y R^7.0 Q^0.5 C^0.2	H Y R^2.3	H Y R^4.3 Q^0.5
127	G R^0.6 W^0.2 K^0.2 E^0.2	R G^7.5 W^0.4	G R^3.7 E^0.1	G W^0.2 R^0.2	G W^0.3 R^0.3	G R^0.8	G	G	G	G R W^0.2 E^0.1 K^0.0	G R	G R W^1.2	G R
128	T A^0.8 N^0.8 S^0.4 P^0.4 H^0.2 I^0.2	T A^1.5 N^1.3 I^0.9 S^0.4 P^0.2	T A^6.7 N^0.3 P^0.3 I^0.1	T N^1.3 I^0.8 S^0.5 P^0.1	T I^0.3 P^0.3	T S^1.5	T	T S^3.7	T S^1.9	T A^1.9 N^0.8 I^0.5 S^0.4 P^0.2 H^0.0	T I^2.0 N^1.8 A^1.2	T I^3.8 N^2.5 A^1.2	T N^2.2 A^1.6 I^0.5
129	M L^48.4 V^1.0 P^0.4 K^0.2	M L^1.1 V^0.2	M L^9.3	M L^10.2 V^0.2 I^0.1	L M^1.3 H^0.3	M L^18.9	L	L	M L^1.9	M L V^0.3 P^0.1 H^0.0 I^0.0 K^0.0	M L V^0.5	M L	M L
130	Q A^0.6 S^0.2 K^0.2	Q P^0.2	Q	Q P^11.3 H^0.1 S^0.1 E^0.1	P Q^1.3 S^0.6	Q	Q	Q	Q	Q P A^0.1 S^0.1 H^0.0 K^0.0 E^0.0	Q P S^0.7 H^0.2 K^0.2 R^0.2	Q P	Q P
131	N D^3.8 K^1.0	N D^11.2 G^0.2	D N^4.2 G^0.4 E^0.1	N D^7.8 H^0.6 K^0.2 S^0.1 T^0.1	N H^1.0 D^0.6 S^0.3	N H^0.8 D^0.8	N	N	N D^3.8	N D H^0.3 K^0.2 S^0.1 G^0.1 T^0.0 E^0.0	N D H^1.1 S^0.4 Y^0.2	N D G^1.2	N D H^0.5 S^0.5 G^0.5
132	L M^0.2 G^0.2 V^0.2	L M^1.3	L M^1.0 P^0.1	L M^0.5	L M^0.3	L	L	L	L	L M^0.6 P^0.0 G^0.0 V^0.0	L M^1.3	L	L
133	H Q^0.2 R^0.2	H	H	H	H	H	H	H	H	H Q^0.0 R^0.0	H D^0.2 N^0.2	H	H
134	D H^0.4 Y^0.4 N^0.2 E^0.2 V^0.2	N D^44.8 S^2.4 I^0.7 H^0.2	D N^5.4 E^4.1 S^0.7 A^0.6 H^0.1 G^0.1	D N^0.9 G^0.1 V^0.1	D	N D^3.8 S^0.8	D	H	D N^1.9	D N H E^0.9 S^0.6 A^0.1 I^0.1 G^0.1 Y^0.1 V^0.1	D N H E^1.3 S^0.4	D N H V^1.2	D N H E^2.1 S^0.5
135	S F^0.2 T^0.2	S A^1.8 Y^0.7 F^0.6 C^0.6 H^0.2 T^0.2	S T^0.7 Y^0.5 H^0.3 N^0.3	S Y^21.3 H^0.8 N^0.8 T^0.6 A^0.5 C^0.5 F^0.2 P^0.2 D^0.1	S T^0.3 Y^0.3	S C^0.8	S	S A^3.7	S T^3.8 A^1.9 Y^1.9	S Y^6.2 A^0.5 T^0.5 H^0.3 C^0.3 N^0.3 F^0.2 P^0.1 D^0.0	S Y^9.7 H^0.9 T^0.7 N^0.7 F^0.5 P^0.5 C^0.2 D^0.2	S Y^5.8 H^1.2 C^1.2 N^1.2	S Y^10.1 C^0.5
136	C T^0.2	C R^0.2 G^0.2	C R^0.1 G^0.1	C	C G^0.3	C	C	C	C	C R^0.1 G^0.1 T^0.0	C	C	C
137	S T^0.8	S	S T^0.5 Y^0.1	S T^0.6	S	S T^20.5	S	S	S T^1.9	S T^1.3 Y^0.0	S Q^0.2 T^0.2	S	S Q^0.5 T^0.5
138	R K^1.4 G^0.2	R K^0.9	R K^1.9 E^0.1	R K^0.6	R K^0.3	R T^0.8	R	R	R	R K^1.0 T^0.0 G^0.0 E^0.0	R S^0.2 Q^0.2 W^0.2 I^0.2 K^0.2	R	R Q^0.5 G^0.5
139	Q E^0.2	N H^1.8 K^1.5 D^0.6 P^0.2 R^0.2	H K^1.4 T^0.7 Q^0.4 D^0.4 R^0.1	N S^0.8 T^0.5 D^0.5 K^0.3 H^0.2 Q^0.1 E^0.1	N D^1.3	N H^0.8	Q	N	Q N^3.8	N Q H K^0.7 D^0.4 T^0.3 S^0.2 R^0.1 E^0.1 P^0.0	N Q H P^0.7 K^0.4 F^0.2 S^0.2 T^0.2 R^0.2	N Q H T^1.2	N Q H K^1.1
140	L I^0.2	L	L	L I^0.1	L	L	L	L	L	L I^0.1	L	L	L
141	Y F^0.2	Y F^2.8 S^0.2	Y F^0.4 R^0.1	Y F^0.5	Y F^0.3	Y	Y	Y	Y F^5.8	Y F^0.8 S^0.0 R^0.0	Y F^0.4 S^0.2	Y	Y
142	V A^0.2 I^0.2 G^0.2	V I^1.1 D^0.2 G^0.2	V D^0.5 I^0.3 A^0.1 N^0.1 E^0.1	V E^0.8 A^0.7 I^0.3 T^0.1 D^0.1 G^0.1	V D^0.3 I^0.3	V	V	V	V	V I^0.4 A^0.2 D^0.2 E^0.2 G^0.1 T^0.0 N^0.0	V I^1.3 E^0.7 D^0.4 A^0.2 N^0.2	V D^1.2	V E^1.1
143	S A^0.4 T^0.2	S P^0.2 Y^0.2	S T^0.1 Y^0.1	S T^0.1 C^0.1	S T^0.3	S T^0.8	S	S	S	S T^0.2 A^0.1 Y^0.1 C^0.0 P^0.0	S A^0.2 F^0.2 C^0.2	S	S
144	L P^0.2	L	L I^0.3	L C^0.1	L	L	L	L	L	L I^0.1 C^0.0 P^0.0	L	L	L
145	M L^1.0	M L^1.5 V^0.2	L M^5.9 V^0.5 F^0.1	L M^3.6	M L^0.6	L	M	L	M L^1.9	M L V^0.2 F^0.0	M L	M L	M L
146	L	L	L V^0.1	L V^0.1	L	L	L	L	L	L V^0.1	L V^0.2	L	L S^0.5
147	L	L	L V^0.3	L	L	L	L	L	L	L V^0.1	L V^0.2	L	L
148	Y	Y F^0.2 C^0.2	Y F^0.1 H^0.1 D^0.1	Y S^0.1	F Y^0.6	F Y^6.2	Y	Y	Y	Y F H^0.0 S^0.0 C^0.0 D^0.0	Y F D^0.2	Y F	Y F
149	K Q^3.4 N^0.2 E^0.2	K Q^0.5 E^0.2	K Q^0.8 T^0.1 E^0.1	Q K^17.4	K Q^0.3	Q K^16.8	K	Q K^3.7	K Q^48.1	K Q E^0.1 T^0.0 N^0.0	K Q L^0.2	K Q	K Q
150	T	T A^0.2	T	T	T A^0.6	T	T	T	T	T A^0.1	T	T	T
151	Y F^0.6 S^0.2	Y	F Y^0.5 S^0.1	F L^0.6 Y^0.3	F Y^0.6 C^0.3 L^0.3	L F^8.4	F	F	F Y^7.7	F Y L S^0.1 C^0.0	F Y L	F Y L	F Y L
152	G	G E^0.2	G	G	G R^0.6	G	G	G	G	G R^0.1 E^0.0	G E^0.2	G	G
153	W R^9.4 Q^0.2	R W^2.2 Q^0.2	R W^1.9 Q^1.0	R W^14.5 Q^0.3 K^0.1	R H^0.3	R Q^0.8	R	R	R Q^1.9	R W Q^0.4 H^0.0 K^0.0	R W Q^0.7 C^0.2	R W	R W
154	K E^0.2	K Q^0.4	K Q^0.3 E^0.1	K Q^0.2	K	K	K	K	K	K Q^0.2 E^0.1	K Q^0.2	K	K
155	L M^0.2	L P^0.2	L W^0.1	L	L	L	L	L	L	L M^0.0 W^0.0 P^0.0	L M^0.2	L	L
156	H	H	H	H Q^0.1	H	H	H	H	H	H Q^0.0	H	H	H
157	L M^2.0	L M^0.4	L M^0.1 V^0.1	L M^0.9	L	L	L	L	L	L M^0.7 V^0.0	L M^0.4	L M^1.2	L
158	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y
159	S	S T^0.2	S P^0.3	S T^0.1	S P^0.3	S	S	S	S	S T^0.1 P^0.1	S	S	S
160	H	H	H	H R^0.3	H	H	H	H	H	H R^0.1	H	H	H
161	P	P	P	P S^0.1	P	P	P	P	P	P S^0.0	P	P	P
162	I T^0.2	I V^0.5	I V^0.4 L^0.3	I	I V^0.3	I	I	I	I	I V^0.2 L^0.1 T^0.0	I V^0.2	I	I
163	V I^39.0	I V^0.9	I V^0.8 N^0.1	I V^4.5	I V^0.3	I	I	I V^3.7	I V^7.7	I V N^0.0	I V L^0.2	I V	I V
164	L M^1.2	L M^0.7	L M^1.2 F^0.1	L M^3.1	M	L	L	L	L	L M F^0.0	L M F^0.2	L M F^1.1	L M F^0.5
165	G D^0.2	G	G	G A^0.1	G Q^0.3	G	G	G	G	G A^0.0 Q^0.0 D^0.0	G	G	G
166	F	F	F L^0.1	F	F L^0.3	F	F	F	F	F L^0.1	F	F	F
167	R	R	R	R	R F^0.3 Q^0.3	R	R	R	R	R F^0.0 Q^0.0	R D^0.2	R	R
168	K	K	K	K	K	K	K	K	K	K	K	K	K
169	I L^0.2	I T^0.2	I V^0.4 N^0.1 L^0.1	I L^0.3	I	I	I	I	I	I L^0.2 V^0.1 T^0.0 N^0.0	I	I	I
170	P	P	P R^0.1	P	P	P	P	P	P	P R^0.0	P	P	P
171	M	M K^0.2	M	M	M	M	M	M	M	M K^0.0	M	M T^1.1	M
172	G	G E^0.2	G R^0.1 E^0.1	G	G	G	G	G	G	G E^0.1 R^0.0	G	G	G
173	V A^0.2	V	V L^0.5 G^0.3 A^0.1 M^0.1	V M^0.1	V A^0.3	V	V	V	V	V A^0.1 M^0.1 G^0.1 L^0.1	V L^4.8	V	V L^4.8 M^0.5
174	G	G	G C^0.1	G A^0.2	G	G	G	G	G	G A^0.1 C^0.0	G	G	G
175	L	L	L I^0.1	L	L I^0.3	L	L	L	L	L I^0.1	L	L I^1.1	L
176	S	S	S N^0.1 G^0.1	S N^0.1	S	S	S	S	S	S N^0.1 G^0.0	S N^0.2 I^0.2	S	S
177	P	P	P	P	P	P	P	P	P	P	P T^0.2	P	P
178	F S^0.2	F	F	F	F	F	F	F	F	F S^0.0	F	F	F
179	L	L	L	L	L	L	L	L	L	L	L	L	L
180	L	L W^0.2	L M^0.1	L M^0.1	L	L	L	L	L	L M^0.1 W^0.0	L M^31.7	L M^1.1	L M^29.1
181	A S^0.2 G^0.2	A T^0.2	A G^0.1	A S^0.1 T^0.1	A	A S^0.8	A	A	A	A S^0.1 T^0.1 G^0.1	A T^0.9 S^0.4 V^0.4	A V^11.1 T^3.3 S^2.2	A V^3.2 T^1.6 S^1.1
182	Q	Q	Q H^0.1	Q	Q	Q	Q	Q	Q	Q H^0.0	Q	Q	Q
183	F	F	F	F L^0.2	F	F	F	F	F	F L^0.1	F	F	F
184	T	T	T A^0.1 P^0.1	T A^0.1	T	T I^0.8	T	T	T	T A^0.1 I^0.0 P^0.0	T S^1.1 L^0.4 A^0.2 I^0.2	T	T S^1.6 A^0.5
185	S G^0.2	S R^0.2	S	S T^0.1 G^0.1	S	S	S	S	S	S G^0.1 T^0.0 R^0.0	S C^0.2 G^0.2	S	S
186	A S^0.2	A T^0.2	A S^0.3	A T^0.1	A	A	A	A	A	A S^0.1 T^0.1	A S^0.2	A	A
187	I L^1.6	I V^8.5 L^1.8	I L^0.5	I L^1.8 V^0.1	I V^0.6 L^0.3	I L^0.8	I	I	I	I V^1.5 L^1.2	I V^3.1 L^0.7	I V^4.5	I V^2.6
188	C R^0.2	C	C Y^0.1	C	C	C	C	C	C	C R^0.0 Y^0.0	C	C	C
189	S	S	S L^0.1	S P^0.1	S	S	S	S	S T^1.9	S T^0.0 P^0.0 L^0.0	S	S	S
190	V G^0.2	V L^0.2	V M^0.1 I^0.1	V M^0.2	V M^0.3	V	V	V	V M^1.9	V M^0.2 I^0.0 G^0.0 L^0.0	V M^0.2	V	V
191	V I^1.2 F^0.2	V I^0.4	V I^0.6 G^0.1	V A^0.1 D^0.1	V I^0.6	V	V	V	V	V I^0.4 A^0.0 F^0.0 D^0.0 G^0.0	V I^0.7	V	V I^1.1
192	R S^0.2	R	R C^0.1	R	R	R	R	R	R	R S^0.0 C^0.0	R C^0.2	R	R
193	R M^0.2	R	R K^0.3	R K^0.1 G^0.1	R	R	R	R	R	R K^0.1 M^0.0 G^0.0	R K^0.2	R	R
194	A D^0.2	A T^0.7 S^0.4 L^0.2	A S^0.1 T^0.1	A T^0.2 I^0.1 V^0.1	A T^0.3	A	A	A T^3.7	A	A T^0.3 S^0.1 D^0.0 I^0.0 L^0.0 V^0.0	A S^0.4 V^0.2	A	A S^0.5 T^0.5
195	F	F	F S^0.1	F	F	F	F	F	F	F S^0.0	F	F	F
196	P	P S^0.2	P	P L^0.1	P	P	P	P	P	P S^0.0 L^0.0	P	P	P
197	H R^0.2	H P^0.2	H	H	H	H	H	H	H	H P^0.0 R^0.0	H	H	H
198	C	C	C W^0.1	C	C	C	C	C	C	C W^0.0	C	C Y^1.1	C
199	L V^0.4	L M^0.2	L V^1.5 M^0.3	L	L	L	L	L	L	L V^0.4 M^0.1	L V^0.9	L	L V^2.6
200	A	A	A V^0.1	A	A	A	A	A	A	A V^0.0	A V^1.1	A	A V^0.5
201	F	F	F	F L^0.1	F	F	F	F	F	F L^0.0	F	F	F
202	S C^0.2 R^0.2	S T^0.2	S G^0.1	S T^0.1	S	S N^0.8	S	S	S	S T^0.1 C^0.0 N^0.0 R^0.0 G^0.0	S G^0.7	S	S G^1.0
203	Y	Y	Y H^0.1	Y	Y	Y	Y	Y	Y	Y H^0.0	Y H^0.2	Y	Y
204	M I^0.8	M I^0.2	M I^0.3 R^0.1 L^0.1 V^0.1	M V^0.1	M	M	M	M	M	M I^0.2 V^0.1 R^0.0 L^0.0	M V^21.7 I^20.6 S^0.2	M I^1.1	M V^24.0 I^13.7
205	D	D N^0.2	D E^0.1	D	D	D	D	D	D	D N^0.0 E^0.0	D	D	D
206	D	D N^0.2	D	D V^0.1	D	D	D	D	D	D N^0.0 V^0.0	D	D	D
207	V M^0.8 I^0.6	V M^11.3 L^1.1 I^0.2	V L^0.5 I^0.4 M^0.1	V I^0.1 L^0.1	V	L	V	L V^3.7	V	V L M^2.1 I^0.3	V L I^1.1 M^0.9	V L M^3.4	V L I^1.6 M^0.5
208	V	V	V	V I^0.1 E^0.1	V	V	V	V	V	V I^0.0 E^0.0	V	V	V
209	L	L W^0.2	L	L S^0.1	L	L	L	L	L	L S^0.0 W^0.0	L	L	L
210	G	G	G	G	G	G	G	G	G	G	G	G	G
211	A	A T^0.9 S^0.7	A T^0.1	A T^0.1	A	A	A	A	A	A T^0.2 S^0.1	A T^0.2	A	A
212	K T^0.8 R^0.6	K	K R^0.3	K N^0.5 T^0.3 R^0.2 Q^0.1	K R^0.6 T^0.3	K	K	K	K	K T^0.3 R^0.3 N^0.1 Q^0.0	K T^0.4	K R^2.2	K
213	S T^2.1	S T^4.4	S T^2.5 P^0.1	S T^3.5 N^0.6 A^0.1 P^0.1	S T^6.8	S	S	S	S	S T^3.3 N^0.2 P^0.1 A^0.0	S T^3.6 N^0.2	S T^1.1	S T^2.1
214	V A^0.4 I^0.4	V A^0.4 I^0.4 E^0.4	V I^0.5 A^0.3 T^0.1 P^0.1 E^0.1	V A^0.7 E^0.7 T^0.1 D^0.1 I^0.1	V I^1.0 E^1.0 A^0.3	V P^1.0	V	V	V	V A^0.4 I^0.4 E^0.4 T^0.1 P^0.1 D^0.0	V A^0.7 I^0.2 P^0.2	V	V
215	Q E^0.2	Q H^0.9	Q H^0.3 R^0.1	Q S^3.8 H^2.8 P^1.6 T^0.1 R^0.1	Q H^0.6 P^0.3 R^0.3	Q	Q	Q	Q	Q H^1.1 S^1.0 P^0.5 R^0.1 T^0.0 E^0.0	Q S^3.9 H^1.1 P^0.2	Q S^4.6 H^1.1	Q S^1.6
216	H	H	H	H	H	H	H	H	H	H	H	H	H
217	R L^40.2	L	L R^0.7 P^0.3	L R^0.5	L R^0.3	L	L	L	L	L R P^0.1	L R	L R	L R
218	E D^0.6	E D^0.4	E D^0.4	E D^0.3	E	E	E	E	E	E D^0.3	E	E	E
219	S A^15.4 F^0.2	S A^1.1 T^0.4	S A^1.1 T^0.4	S A^2.8 T^0.1	S A^0.6	S	S	S A^7.4	S A^5.8	S A^3.8 T^0.2 F^0.0	S A^5.9 F^0.2 T^0.2	S A^5.7 P^1.1	S A^4.3
220	L	L I^4.8 V^2.4	L F^0.1	L	L I^0.3	L	L	L I^7.4	L I^5.8	L I^1.0 V^0.4 F^0.0	L I^0.9 V^0.7	L	L
221	Y F^0.4	Y H^1.8 C^0.2	F Y^8.6 L^0.3 S^0.1	F Y^2.2 S^0.1 I^0.1 L^0.1	Y	Y	Y	Y	Y F^1.9	Y F H^0.3 S^0.1 L^0.1 C^0.0 I^0.0	Y F H^0.5	Y F C^1.2	Y F
222	T S^0.4 A^0.2	A T^7.3 P^0.2	T A^0.4 S^0.1	T S^0.1	T	T	T	T	T	T A S^0.1 P^0.0	T A	T A	T A
223	A S^0.6 T^0.2 G^0.2	A	S A^19.1 T^1.1 C^0.1	A S^0.3 T^0.1	S A^7.5	A	A	A	A	A S T^0.3 C^0.0 G^0.0	A S T^0.2 G^0.2	A S	A S
224	V I^0.2	V I^0.6	I V^14.6	V I^0.1 E^0.1	V A^0.3 I^0.3	V	V	V	V I^3.8	V I A^0.0 E^0.0	V I	V I	V I
225	T I^0.2	T S^0.9	T A^0.1	T S^0.5 A^0.2 V^0.1	T	T	T	T	T	T S^0.3 A^0.1 I^0.0 V^0.0	T V^0.2	T	T S^1.1
226	N H^0.2 I^0.2	N H^10.2 T^0.4	N T^0.7 H^0.5 A^0.1	N I^0.1	N I^0.3	N	N S^4.8	N	N	N H^1.9 T^0.2 I^0.1 A^0.0 S^0.0	N H^0.7	N H^1.1	N H^0.5
227	F	F S^0.2	F	F	F	F	F	F	F	F S^0.0	F L^0.2	F	F
228	L	L	L F^0.1 M^0.1	L	L	L	L	L	L	L F^0.0 M^0.0	L F^0.5	L	L
229	L M^0.6 V^0.2	L M^2.2 V^0.9 F^0.2 S^0.2	L V^1.9 M^0.6 F^0.1 S^0.1	L M^0.3 F^0.1 W^0.1 G^0.1 V^0.1	L M^1.9 V^0.3	L	L	L	L V^1.9	L M^0.9 V^0.7 F^0.1 S^0.1 W^0.0 G^0.0	L V^2.8 M^2.4 F^1.2 S^0.9 W^0.7 C^0.2	L V^2.3 G^1.2	L V^2.2 S^0.5 M^0.5
230	S A^0.2	S P^0.2 V^0.2	S A^0.3 P^0.3 L^0.1	S T^0.1	S A^0.3	S	S	S	S	S A^0.1 P^0.1 T^0.0 L^0.0 V^0.0	S	S	S
231	L	L P^0.2	L W^0.1	L V^0.8	L	V L^1.0	L	V	L	L V W^0.0 P^0.0	L V S^0.2	L V	L V
232	G	G	G	G	G	G	G	G	G	G	G	G	G
233	I V^0.4	I V^0.6 L^0.2	I V^1.2 T^0.1	I V^0.9	I	I	I	I	I	I V^0.7 T^0.0 L^0.0	I V^0.5 L^0.2	I V^1.1	I V^0.5
234	H	H Q^0.4 R^0.2	H	H	H Q^0.3 R^0.3	H Q^2.0	H	H	H	H Q^0.2 R^0.1	H	H	H
235	L	L I^1.3 V^1.3	L I^0.3	L I^0.2	L	L	L	L	L	L I^0.4 V^0.2	L I^0.7	L I^1.1	L
236	N	N T^0.2	N	N	N	N	N	N	N	N T^0.0	N	N T^14.4	N T^2.2 R^0.6
237	P Q^0.2	P T^0.2	P	P T^5.6	P S^11.1 A^1.9	T	P	T	P S^6.2	P T S^1.1 A^0.2 Q^0.0	P T	P T	P T H^0.5 C^0.5
238	N H^0.9 S^0.9 T^0.7 D^0.2	H Q^4.0 N^0.6 R^0.2 Y^0.2	N T^8.4 A^2.3 H^2.3 S^0.6 D^0.4 E^0.3	N H^2.3 T^1.1 D^0.8 S^0.7 G^0.1 E^0.1	N H^2.2 T^2.2 D^0.7 A^0.4 S^0.4	S A^14.6 F^1.0	N T^11.1 D^5.6	A S^3.7	N A^4.2 T^2.1	N A S H T^2.7 Q^0.7 D^0.4 E^0.1 F^0.0 R^0.0 G^0.0 Y^0.0	N A S H T^1.7 Q^0.2 D^0.2 Y^0.2	N A S H T^6.8 D^2.3 E^1.1	N A S H T^4.4 D^0.5
239	K L^5.3	K I^0.4	K	K	K N^0.4	K	K	K	K	K L^0.8 I^0.1 N^0.0	K	K	K
240	T A^5.3	T N^0.4 P^0.2	T N^0.1	T	T Q^0.4	T	T	T	T	T A^0.8 N^0.1 Q^0.0 P^0.0	T	T	T I^0.6
241	K R^0.2 Y^0.2	K Q^0.4 R^0.4	K R^0.3 Q^0.1 N^0.1	K Q^0.4	K R^0.4	K	K	K	K	K Q^0.2 R^0.2 N^0.0 Y^0.0	K Q^0.3 N^0.3	K	K Q^0.6 R^0.6
242	R A^5.3 K^0.4	R K^0.2	R	R K^3.2	R	R	R	W R^3.7	R	R W K^0.9 A^0.8	R W K^0.3	R W	R W
243	W	W	W	W	W	W	W	W	W	W	W G^0.3	W	W
244	G	G	G	G	G	G	G	G	G	G	G	G	G
245	Y	Y H^0.2	Y C^0.1 K^0.1 R^0.1	Y H^0.7	Y	Y	Y	Y	Y	Y H^0.2 C^0.0 K^0.0 R^0.0	Y H^0.8 S^0.3	Y H^1.2	Y
246	S T^0.2	S	S T^0.4 A^0.3	S H^0.4	S P^0.8	T S^16.8	S	S T^11.1	S	S T A^0.1 H^0.1 P^0.1	S T P^0.5	S T	S T C^0.6
247	L	L	L F^0.1	L	L P^0.4	L	L	L	L	L F^0.0 P^0.0	L	L	L
248	N H^0.5	N H^3.5 Q^0.2	N H^2.7	H N^33.3 Q^0.5	N H^26.7 Q^2.5	H N^17.7	N	H	N H^4.2	N H Q^0.4	N H	N H	N H
249	F S^0.2	F	F L^0.1	F S^0.1	F	F	F	F	F	F S^0.1 L^0.0	F	F	F
250	M K^0.2	M	M	M T^0.1	M	M	M	M	M	M T^0.0 K^0.0	M	M	M L^0.6
251	G V^0.2	G	G	G	G	G	G	G	G	G V^0.0	G	G	G
252	Y	Y N^0.3	Y	Y	Y N^0.8	Y	Y	Y	Y	Y N^0.1	Y	Y	Y
253	I V^37.4 R^0.5 L^0.2	V I^3.4 R^0.3 E^0.3	V I^3.8 E^0.6 R^0.5 T^0.2	V I^0.9 S^0.4 T^0.3	V I^2.5	V I^9.5	V	I R^11.1 V^7.4	V I^4.2	V I R^0.3 E^0.2 S^0.1 T^0.1 L^0.0	V I T^0.6 R^0.3	V I S^1.6	V I S^0.6 R^0.6
254	I	I V^0.3	I L^0.2	I	I	I	I	I	I	I L^0.0 V^0.0	I	I	I
255	G	G	G	G D^0.1	G S^0.4	G	G	G	G	G S^0.0 D^0.0	G	G	G
256	S C^1.2	S G^7.5 C^4.3 N^0.6 A^0.3	S C^6.2 G^0.6 M^0.2	C S^14.3 G^1.8 A^0.1	S C^0.4	S	S	S	S C^2.1 G^2.1	S C G^1.7 A^0.1 N^0.1 M^0.0	S C G^3.7	S C	S C G^1.3
257	W Y^0.2	W F^0.3 L^0.3	W Y^0.2	Y W^15.7 H^2.0 G^0.4 F^0.3	W F^0.4	W	W	W	W	W Y H^0.6 F^0.2 G^0.1 L^0.0	W Y H^1.6	W Y F^3.3	W Y
258	G	G	G	G	G	G	G	G	G	G	G V^0.3	G	G
259	T S^9.7 A^0.5	T S^10.3	T S^0.9 A^0.5	S T^0.4 A^0.3 P^0.1	S	T S^44.2 A^17.9	T	T	T S^8.3	T S A^0.9 P^0.0	T S	T S	T S P^0.6
260	L	L W^0.3	L	L W^0.1	L	L	L	L	L	L W^0.1	L	L	L W^0.6
261	P	P	P	P	P	P	P	P	P	P	P	P	P
262	Q	Q H^0.3	Q R^0.2	Q	Q	Q	Q	Q	Q H^2.1	Q H^0.1 R^0.0	Q H^0.3	Q	Q
263	D E^3.1	E D^2.0 N^0.9 Q^0.3	D Q^0.8 N^0.2	D E^15.3 S^1.6 N^0.6 A^0.3 T^0.3	E D^10.5 N^0.4	D E^1.1	E	E	D E^8.3	D E S^0.4 N^0.4 Q^0.2 A^0.1 T^0.1	D E A^0.7 N^0.3	D E S^1.8	D E N^0.6
264	H	H	H	H	H	H	H	H	H	H	H	H	H Q^0.6
265	I	I	I	I	I	I	I	I	I	I	I	I	I
266	V I^8.5 R^0.7 E^0.2 L^0.2	V I^1.7 A^1.1 M^0.6 T^0.3 G^0.3	V I^4.4 R^0.9 K^0.2	I R^11.4 V^3.9 K^2.5 T^1.3 M^0.4 L^0.3	R K^3.9 T^1.3 I^1.3 V^0.4	V I^1.1	T	V	I V^27.1 R^2.1	V I T R K^1.1 A^0.2 M^0.2 L^0.1 G^0.0 E^0.0	V I T R K^1.4 M^0.7 A^0.4 G^0.4	V I T R	V I T R K^1.3
267	Q L^0.7 H^0.5	Q L^11.1 S^7.7 H^2.6 R^1.1 A^0.9 P^0.9 F^0.6 W^0.6 M^0.6 E^0.3	L Q^24.9 H^10.3 M^1.5 F^0.6 S^0.3 D^0.3 R^0.3 T^0.2 V^0.2 I^0.2	Q H^13.3 L^1.9 R^0.3	M L^14.0 Q^2.2 V^1.8 T^1.3 I^1.3 R^0.9 S^0.4	H Q^17.9	Q K^5.6	H Q^7.4	Q	Q H M L S^1.2 R^0.4 F^0.2 T^0.2 V^0.2 I^0.2 A^0.1 W^0.1 P^0.1 D^0.1 K^0.0 E^0.0	Q H M L K^0.7 R^0.3	Q H M L	Q H M L
268	K	K N^0.6	K R^0.2	K T^0.1	K R^0.4	K	K	K	K	K N^0.1 R^0.1 T^0.0	K R^0.3	K	K
269	I L^2.5	I L^2.0 F^0.3 T^0.3 V^0.3	I L^43.0 S^0.2 P^0.2	I L^2.6	I	I L^5.7	I	I	I	I L^12.9 F^0.0 S^0.0 T^0.0 P^0.0 V^0.0	I L^9.4	I L^10.5	I L^8.3 V^0.6
270	K T^0.5 R^0.2	K T^1.1 R^1.1 N^0.6 Q^0.3	K Q^0.5 A^0.3 R^0.3 E^0.3 M^0.2 T^0.2	K R^0.4 T^0.1	K Q^1.7 S^0.4 T^0.4 R^0.4	K	K	K	K R^25.0 N^2.1	K R^0.9 T^0.4 Q^0.3 A^0.1 N^0.1 E^0.1 S^0.0 M^0.0	K R^1.0 S^0.3 Q^0.3	K R^3.5	K R^0.6
271	H Q^2.2 N^2.0 C^1.7 D^1.0 S^0.2 R^0.2	M Q^20.7 L^19.5 S^4.6 I^1.1 T^0.9 V^0.9 H^0.3 R^0.3	Q H^3.6 N^1.1 E^0.6 K^0.5 R^0.5 L^0.3 M^0.2 D^0.2	E D^16.8 Q^0.7 A^0.3 H^0.1	D N^1.3 H^0.4 Q^0.4 E^0.4	D E^42.0 A^1.1	Q	D N^3.7	Q K^14.6 H^2.1	Q D H M E L^2.8 N^0.8 S^0.7 K^0.4 C^0.3 R^0.2 I^0.2 A^0.1 T^0.1 V^0.1	Q D H M E L^2.5 A^0.4 S^0.4 T^0.4 N^0.4 K^0.4 R^0.4	Q D H M E L^5.4 S^1.8	Q D H M E N^1.3 L^1.3
272	C	C W^0.9	C S^0.2	C	C	C L^1.1	C	C	C	C W^0.1 S^0.0 L^0.0	C	C	C
273	F	F L^0.3	F V^0.2	F	F	F	F	F	F	F L^0.0 V^0.0	F	F	F
274	R K^0.7	R K^1.7 T^0.6	R Q^0.5	R K^0.9	R G^0.4	R	R	R	R	R K^0.6 Q^0.1 T^0.1 G^0.0	R K^0.7 G^0.3	R	R I^0.6 K^0.6
275	K Q^0.5 E^0.2 L^0.2	K	K Q^0.2 T^0.2 I^0.2	K	K N^0.9	K	K	K	K	K Q^0.1 N^0.1 T^0.0 I^0.0 E^0.0 L^0.0	K Q^0.3	K	K
276	L	L I^0.6	L I^0.2	L I^0.3 P^0.1	L	L V^2.3	L	L	L I^2.1	L I^0.2 V^0.1 P^0.0	L	L	L
277	P	P	P	P	P	P	P	P	P	P	P	P	P
278	V I^4.0 L^0.2	V I^0.6 A^0.3 G^0.3	V I^20.8 T^1.1 L^0.6 C^0.3 M^0.2	V I^5.5 C^0.1	V I^0.4	V	V	V	V I^6.2	V I^7.9 T^0.3 L^0.2 C^0.1 A^0.0 M^0.0 G^0.0	V I^12.8 T^0.7 L^0.4	V I^12.2	V I^11.0 T^0.6 L^0.6
279	N R^0.2	N H^0.6	N S^0.3 C^0.3 H^0.2	N H^3.0 R^0.4 D^0.1	N T^0.4	N	N	N	N	N H^0.9 R^0.2 S^0.1 C^0.1 T^0.0 D^0.0	N K^0.4	N H^2.0	N
280	R S^0.2 P^0.2	R	R S^0.2	R	R	R	R	R	R K^2.1	R S^0.1 K^0.0 P^0.0	R	R	R
281	P	P T^0.3	P	P H^0.1	P H^0.4	P	P	P	P	P H^0.1 T^0.0	P	P	P
282	I A^0.2 V^0.2	I	I V^1.2	I M^0.1 V^0.1	I L^1.3 V^0.4	I	I	I	I V^20.8	I V^0.8 L^0.1 A^0.0 M^0.0	I V^0.4	I	I
283	D	D	D	D	D	D	D	D	D	D	D	D	D
284	W	W G^0.3	W	W	W	W	W	W	W	W G^0.0	W	W	W Y^0.7
285	K R^0.2	K	K E^0.3	K	K	K	K	K	K	K E^0.1 R^0.0	K	K	K
286	V	V L^0.3	V	V F^0.1	V A^0.4	V	V	V	V	V A^0.0 F^0.0 L^0.0	V	V	V
287	C	C	C R^0.2	C W^0.4 R^0.1	C R^0.4 V^0.4	C W^1.1	C	C	C	C W^0.2 R^0.1 V^0.0	C	C	C
288	Q	Q P^0.6	Q	Q	Q P^0.4	Q	Q	Q	Q	Q P^0.1	Q	Q	Q
289	R K^0.2	R Q^0.6	R K^0.2	R	R G^0.9	R S^1.1	R	R	R	R Q^0.1 K^0.1 G^0.1 S^0.0	R	R	R
290	I L^0.2 V^0.2	I L^0.9	I L^0.3	I L^0.3 N^0.1	I	I L^1.1	I	I	I	I L^0.4 N^0.0 V^0.0	I M^1.1	I	I M^1.6
291	V A^0.2	V A^0.9 S^0.3 G^0.3	V G^0.2	V G^0.1	V A^0.4	V	T	V	S V^4.2 T^2.1	V S T A^0.2 G^0.1	V S T	V S T	V S T
292	G S^0.2	G	G	G	G	G	G	G	G	G S^0.0	G	G	G
293	L F^0.2 P^0.2	L P^0.3	L I^0.2	L I^0.2	L	L	L	L	L	L I^0.1 P^0.1 F^0.0	L	L	L F^0.8
294	L	L W^0.3	L	L W^0.3 P^0.2	L	L	L	L	L W^2.1	L W^0.2 P^0.0	L	L	L
295	G	G	G	G	G	G	G	G	G	G	G A^1.1	G	G
296	F	F	F	F	F	F	F	F L^3.7	F	F L^0.0	F	F	F
297	A	A V^0.3	A V^0.5	A V^0.2	A	A	A	A	A	A V^0.2	A	A	A
298	A	A G^0.3	A V^0.2	A	A	A	A	A	A	A G^0.0 V^0.0	A V^0.6	A	A
299	P S^0.2	P	P	P	P	P	P	P	P	P S^0.0	P	P	P
300	F	F L^0.3	F	F	F	F	F	F	F	F L^0.0	F	F	F
301	T	T P^0.3	T	T S^0.2	T	T	T	T	T	T S^0.0 P^0.0	T	T	T
302	Q	Q	Q	Q	Q	Q	Q	Q	Q	Q	Q R^0.6	Q	Q
303	C	C W^0.3	C	C	C	C	C	C	C	C W^0.0	C W^0.6	C	C
304	G	G	G	G	G	G	G	G	G	G	G	G	G
305	Y	Y F^0.3	Y F^0.3 T^0.2	Y F^0.3	Y	Y	Y	Y	Y	Y F^0.2 T^0.0	Y F^0.6	Y	Y
306	P	P	P A^0.3 L^0.2	P	P	P	P	P	P	P A^0.1 L^0.0	P	P	P
307	A	A	A	A	A	A	A	A	A	A	A	A	A
308	L	L	L F^0.2	L	L	L	L	L	L	L F^0.0	L	L	L
309	M K^1.0	M K^4.0 L^0.9	M K^1.7 L^1.4 S^0.2 V^0.2	M K^12.4 L^1.4	M L^0.5	M	M	M	M	M K^4.4 L^0.9 S^0.0 V^0.0	M K^5.2	M K^8.3	M K^0.9
310	P	P	P	P	P	P	P	P	P	P	P	P	P
311	L	L	L I^0.5	L	L I^2.3 R^0.5	L I^1.1	L	L	L	L I^0.4 R^0.0	L	L	L
312	Y C^0.5	Y S^0.3	Y S^0.2	Y	Y	Y H^1.1	Y	Y	Y	Y S^0.1 C^0.1 H^0.0	Y D^0.6	Y	Y
313	A S^0.2	A S^0.3 T^0.3	A T^0.5 S^0.3	A S^0.2 T^0.2	A S^0.9 T^0.5	T A^34.1 N^5.7	A	A	A	A T S^0.3 N^0.2	A T	A T	A T
314	C S^0.5	C S^0.6	C S^0.3	C H^0.2	C S^0.9	C	C	C	C S^2.1	C S^0.4 H^0.0	C	C	C
315	I	I M^0.3 K^0.3	I	I	I T^5.9 V^0.9	I	I	I	I	I T^0.5 V^0.1 M^0.0 K^0.0	I	I	I
316	Q	Q H^1.7	Q H^4.6 S^0.2 N^0.2	Q H^0.6	Q H^1.8	T S^2.3	Q	T	Q H^4.3	Q T H^1.9 S^0.1 N^0.0	Q T H^1.1	Q T H^4.1	Q T H^1.7
317	A S^0.5 T^0.2	A S^2.3 T^0.6	S A^34.6 K^0.3 P^0.3 T^0.2 D^0.2	S A^4.4 Y^0.3 T^0.2	S A^1.4 Y^0.5	A T^1.1	A	A	A T^2.1	A S T^0.3 K^0.1 P^0.1 Y^0.1 D^0.0	A S V^0.6	A S	A S
318	K R^6.4	K R^1.1 Q^0.3	K R^0.5 H^0.3	K R^10.9	K R^2.3 Q^0.5 G^0.5	K	K	K N^3.7	K	K R^4.4 H^0.1 Q^0.1 N^0.0 G^0.0	K R^5.1	K	K R^3.4
319	Q R^0.7 K^0.5	Q R^1.1 K^0.9 L^0.3	Q K^1.1 R^0.9 L^0.2	Q P^0.2 R^0.2	Q K^0.5	Q	Q	Q	Q R^2.1	Q R^0.6 K^0.5 L^0.1 P^0.0	Q R^1.1	Q R^2.0	Q
320	A V^0.5 T^0.2	A	A	A T^0.3	A	A	A	A	A	A T^0.1 V^0.1	A	A	A
321	F S^1.5 Y^0.2	F	F	F	F	F	F	F	F	F S^0.2 Y^0.0	F	F	F
322	T L^1.3 I^0.8 F^0.5 S^0.5	T A^0.3 S^0.3 I^0.3 V^0.3	T S^0.5 A^0.2 I^0.2	T S^0.6 I^0.2	T L^1.4 I^0.9	V	T	V	T	T V S^0.4 I^0.3 L^0.3 A^0.1 F^0.1	T V S^0.6 I^0.6	T V	T V I^0.9
323	F	F	F S^0.2 L^0.2	F	F	F	F	F	F	F S^0.0 L^0.0	F	F	F
324	S F^0.8 P^0.8 L^0.3	S	S P^0.2	S P^0.2	S	S	S	S	S	S P^0.2 F^0.1 L^0.0	S	S	S
325	P L^0.3	P L^0.6 T^0.3	P S^2.6 L^0.5 T^0.2	P T^0.6 Q^0.3 L^0.3 S^0.2	P Q^0.5 L^0.5	P	P	P	P	P S^0.7 L^0.4 T^0.2 Q^0.1	P	P	P S^1.7
326	T P^0.3	T I^0.9 V^0.3	T I^0.8 V^0.3	T P^1.2 I^1.1	T I^0.5	T	T	T	T I^2.1	T I^0.7 P^0.4 V^0.1	T I^1.7	T	T
327	Y F^0.3 H^0.3	Y	Y C^0.2	Y C^0.2	Y	Y	Y	Y	Y	Y C^0.1 F^0.0 H^0.0	Y F^0.6	Y	Y
328	K Q^0.3	K R^0.3	K R^0.6	K	K	K	K	K	K	K R^0.2 Q^0.0	K	K	K
329	A T^0.5 G^0.3	A T^1.4 S^0.3	A T^2.6 V^1.5 S^0.3 M^0.2 P^0.2	A T^1.9 V^0.6	A T^2.7	A T^1.1	A	A	A V^2.1	A T^1.8 V^0.6 S^0.1 M^0.0 P^0.0 G^0.0	A T^1.1	A T^2.0	A T^0.9
330	F L^0.3	F L^0.3	F S^0.2 L^0.2	F	F	F	F	F	F	F L^0.1 S^0.0	F	F	F
331	L	L	L R^0.2	L Q^0.2	L	L	L	L	L	L Q^0.0 R^0.0	L	L	L
332	S R^6.5 N^4.3 H^0.3 C^0.3 K^0.3	S R^19.2 N^15.8 H^3.4 T^1.1 C^1.1 Y^0.3	C Y^1.8 R^1.4 K^0.3 S^0.2 W^0.2	C Y^3.5 R^1.4 S^0.3 N^0.2	C Y^1.8 F^0.5 S^0.5	C	C	C R^7.4	C S^4.3 R^2.1	C S R^4.7 N^3.0 Y^1.6 H^0.5 T^0.2 K^0.1 F^0.0 W^0.0	C S R^5.7 N^4.0 Y^2.3 K^1.1	C S R^4.3	C S Y^2.7 R^0.9
333	K Q^8.6 T^6.7 N^2.2 E^0.5 A^0.3 H^0.3 D^0.3	K N^8.4 Q^7.5 H^0.9 T^0.6 E^0.3	K Q^10.6 N^1.5 T^0.6 D^0.3 E^0.3 A^0.2	K Q^1.3 N^0.3 H^0.2 T^0.2 E^0.2	K Q^7.8 T^6.5 N^2.8	K Q^22.7 H^1.1 D^1.1	K	K Q^7.4 H^3.7	K Q^4.3 N^2.1	K Q^7.3 N^2.3 T^1.9 H^0.3 D^0.2 E^0.2 A^0.1	K Q^8.1 T^3.5 E^1.2 A^0.6 N^0.6	K Q^2.1 N^2.1	K Q^8.8 N^2.7 H^0.9
334	Q L^0.3	Q L^0.6	Q L^0.3	Q	Q	Q	Q	Q	Q	Q L^0.2	Q L^0.6	Q	Q
335	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y
336	M L^3.0 V^0.5	L M^3.2 S^0.6 R^0.3 V^0.3	L M^8.0 Q^0.6 I^0.2 R^0.2	L M^5.5 A^0.3 S^0.2 R^0.2	L M^16.9 S^0.5 R^0.5	M	M L^5.6	M L^11.1	M L^25.5 S^4.3 A^2.1	M L S^0.3 Q^0.2 R^0.2 A^0.1 V^0.1 I^0.0	M L R^0.6	M L Q^2.1	M L Q^0.9 I^0.9
337	N D^2.1 H^0.5 T^0.5	N T^9.2 H^2.6 D^1.1 Y^0.3	N H^19.6 T^0.9	N T^3.5 H^1.3 Y^0.2	N T^2.7 D^2.3 H^0.5 Y^0.5	N H^8.0	N	N T^3.7	N T^6.4	N H^6.4 T^3.0 D^0.7 Y^0.1	N H^14.7 T^2.8 D^0.6	N T^4.1	N H^23.5 T^2.6
338	L	L	L P^0.2	L F^0.5	L	L	L	L	L	L F^0.1 P^0.0	L	L	L
339	Y	Y S^0.3 T^0.3	Y	Y	Y F^0.9	Y	Y	Y	Y	Y F^0.1 S^0.0 T^0.0	Y	Y	Y
340	P	P S^0.3	P	P	P	P	P	P	P	P S^0.0	P	P	P
341	V	V	V G^0.2	V D^0.2	V	V A^1.1	V	V	V	V A^0.0 D^0.0 G^0.0	V	V	V
342	A S^0.3	A S^0.3 T^0.3 V^0.3	A T^0.5 V^0.3 G^0.2	A V^0.3 T^0.2	A V^0.5	A	A	A	A V^4.3	A V^0.3 T^0.2 S^0.1 G^0.0	A T^1.1 V^0.6	A	A V^1.8
343	R	R	R	R K^0.2 E^0.2	R	R	R	R	R	R K^0.0 E^0.0	R	R	R
344	Q	Q	Q R^0.2	Q	Q K^0.5	Q	Q	Q	Q	Q K^0.0 R^0.0	Q	Q	Q

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

HBV RT: Mutation prevalence according to genotype and treatment

Team

Resources