Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

HIV Home HBVseq HBV RT Mutations Blast Hits DB Release Notes

HBV RT: Mutation prevalence according to genotype and treatment

 
Mutation Threshold
>= 1% AND >= 2 persons
>= 0.5%
All
 
Mixture
Exclude
Include
 
A detailed description of this page as well as all other pages (and programs) on the HBV site can be found in the Release Notes; Each mutation in the table below is hyperlinked to a web page with information about the sequences containing the mutation.  Abbreviation: N(t)RTI - nucleos(t)ide RT inhibitors; L-nuc. - L-nucleoside analogs (lamivudine, emtricitabine, telbivudine); ETV - entecavir; ANPs - acyclic nucleoside phosphonates (adefovir, tenofovir)



PosN(t)RTI Naive Persons
(by Genotype)
N(t)RTI Treated Persons
(by Treatment)
A


506
B


552
C


734
D


887
E


311
F


132
G


22
H


27
I


52
pooled


3216
L-Nuc.
and/or ETV

458
ANPs


90
L-Nuc.
and/or ETV
+ ANPs
191
1 E
D1.4
E
D7.2
Q0.3
K0.3
E
D0.5
E E
D0.7
Q0.4
E
D5.5
Q
E5.6
E E
K2.1
E
Q
D1.6
K0.1
E
Q
D1.2
K0.8
E
Q
D2.0
E
Q
D2.5
2 D
N0.2
D
N0.3
D
G0.2
E0.2
D
E0.1
D D
N1.1
D D D D
N0.1
E0.1
G0.0
D D D
N0.8
3 W
R0.2
W W
C0.2
W W W W W W W
C0.0
R0.0
W W W
4 G G G
C0.2
R0.2
G G G G G G G
C0.0
R0.0
G G G
5 P P P P P P P P P P P P P
L0.8
6 C C C
R0.2
C
W0.1
C C C C C C
W0.0
R0.0
C
A0.4
V0.4
C C
7 D
A17.8
V12.5
T10.6
G4.3
E1.4
N0.5
Y0.5
F0.2
S0.2
H0.2
T
A19.0
S1.4
D0.5
N0.3
T
A4.4
I0.8
N0.6
S0.3
Q0.3
A
T4.3
V2.2
D1.4
S0.4
G0.3
P0.1
T
S0.7
Y
H18.7
N1.1
I1.1
T
D5.6
Y T
N52.1
S4.2
H2.1
Y2.1
T
Y
A
D
V2.6
N1.2
H0.7
G0.7
S0.6
E0.2
I0.2
Q0.1
F0.0
P0.0
T
Y
A
D
F5.5
V1.2
S0.4
E0.4
T
Y
A
D
S2.0
T
Y
A
D
E0.8
V0.8
8 E
D9.0
K0.5
A0.2
Q0.2
E E
H0.3
E
Q0.3
D0.1
E E E E E E
D1.4
H0.1
Q0.1
K0.1
A0.0
E
D4.9
N0.4
E E
Q0.8
D0.8
9 H
Y0.7
Q0.5
H
Y0.8
D0.3
N0.3
H
Y22.2
N1.1
D0.5
H
Y0.8
N0.5
L0.1
H
Y0.4
H H
Y5.6
H H
Y6.2
H
Y6.1
N0.4
Q0.1
D0.1
L0.0
H
Y5.3
D0.4
N0.4
H
Y4.1
H
Y4.2
N0.8
10 G
R0.2
G G
A0.1
G G G G G G G
A0.0
R0.0
G G G
11 E
Q0.5
K0.2
E
D0.3
E
Q0.4
H0.3
D0.3
K0.3
E
K0.9
K
R8.9
E1.0
N0.7
Q0.3
T0.3
Q
E30.8
E E E
K5.8
E
Q
K
R1.0
H0.1
D0.1
N0.1
T0.0
E
Q
K
E
Q
K
E
Q
K
D1.7
R0.8
12 H
R0.5
Q0.2
H
Q0.5
H
N0.1
H H H H
Y5.6
H H H
Q0.1
R0.1
N0.0
Y0.0
H
N0.4
H H
13 H
Y0.7
N0.2
R
H3.7
L2.2
S0.3
N0.3
N
H23.3
S3.6
R1.7
Y0.6
L0.5
F0.3
H
N0.4
Y0.4
P0.1
L0.1
H
Y1.3
H
Y22.0
H H H
Y1.9
H
N
R
Y1.3
S0.9
L0.4
F0.1
P0.0
H
N
R
S0.8
D0.4
L0.4
H
N
R
S6.4
H
N
R
S0.8
C0.8
L0.8
14 I I
V0.3
I I
V0.1
I
V1.0
I
V1.1
I I I I
V0.2
I I I
15 R
K0.2
E0.2
R
T0.3
K0.3
R R
T0.1
K0.1
R
K2.3
T0.3
R R R R R
K0.4
T0.1
E0.0
R
K1.5
R R
16 I
T3.3
S0.2
T
I0.8
I
T1.1
I
T5.9
L0.1
I
T1.0
T I T I
T1.9
I
T
S0.0
L0.0
I
T
V0.4
I
T
I
T
17 P P
H0.3
P P P P P P P P
H0.0
P P P
18 R
K2.1
R
K1.1
T0.3
R
K0.6
R
G0.5
S0.1
R
M0.3
K0.3
G0.3
R R R
K3.7
R R
K0.7
G0.2
S0.0
M0.0
T0.0
R
K0.8
S0.4
R
K2.1
R
S0.8
19 T
A0.2
T T
S0.1
T T T T T T T
A0.0
S0.0
T T T
20 P P P
N0.3
S0.1
P P P P P P P
N0.1
S0.0
P P P
21 A
S0.5
T0.5
A
S0.3
G0.3
A
S0.4
G0.1
A
S13.6
T1.1
A A A S A
T1.9
A
S
T0.4
G0.1
A
S
A
S
T2.0
A
S
22 R R R R R
C0.3
R R R R R
C0.0
R R R
23 V
I0.2
V
I0.8
V
I1.3
V
I0.4
V
I0.7
V V V V
I27.5
V
I1.2
V
I0.4
V
I2.0
V
24 T T
P0.3
T T
S0.1
T T T T T T
S0.0
P0.0
T
A0.4
T T
25 G G G
D0.1
G G G G G G G
D0.0
G G G
26 G
R0.2
G
E0.3
G G
R0.1
G G G G G G
R0.1
E0.0
G G G
E0.8
27 V
del0.2
I0.2
V
I0.8
V V V
I3.3
V
G1.1
V V I
V53.8
V
I
del0.0
G0.0
V
I
A1.1
V
I
V
I
28 F
L0.2
F
L0.3
F F
S0.1
F F F F F F
L0.1
S0.0
F F F
29 L
S0.2
L L L
F0.5
L
F0.3
L L L L L
F0.2
S0.0
L
I0.4
L L
30 V V
I0.3
V V V V V V V V
I0.0
V V V
31 D
N0.2
D D
N0.1
E0.1
D
N0.2
D D D D D
N1.9
D
N0.2
E0.0
D D D
32 K K
Q0.5
K
R0.3
K K
N0.3
K K K K K
Q0.1
R0.1
N0.0
K K K
33 N N
S0.3
N
S0.1
N
D0.1
N
H0.3
N N N N
K1.9
N
S0.1
H0.0
D0.0
K0.0
N N N
34 P P P
L0.1
P
L0.2
H0.1
P
H0.3
P P P P P
H0.1
L0.1
P P P
35 H H H
R0.3
Q0.1
N0.1
L0.1
Y0.1
H
Q0.9
N0.1
H
Q0.3
H
Q1.1
H H H H
Q0.4
N0.1
R0.1
L0.0
Y0.0
H H H
36 N N N N
H0.1
K0.1
N N N N N N
H0.0
K0.0
N N N
37 T
P0.2
T
S0.3
T
A0.3
S0.1
P0.1
T
A0.2
S0.1
T
S1.0
T
A1.1
S1.1
T T T T
S0.3
A0.2
P0.1
T T T
38 A
T2.6
S0.5
E0.5
T
A6.8
S0.5
T
A5.1
K0.8
S0.5
P0.2
A
E4.6
K3.4
T0.5
S0.4
A
T0.7
E0.7
T
K1.1
E1.1
A T
K29.6
A
T3.8
A
T
K1.5
E1.5
S0.4
P0.0
A
T
E4.9
K1.1
A
T
E2.1
A
T
39 E
K0.2
E
A0.3
K0.3
E E
K0.2
E E E E E E
K0.1
A0.0
E E E
40 S
F0.2
S S
A0.3
S S
T0.3
S
A1.6
S S S S
A0.1
F0.0
T0.0
S
A0.7
S S
A0.8
41 R R
K0.5
R
K0.4
T0.1
R R
I0.3
R R R R R
K0.2
T0.0
I0.0
R
I0.4
R R
42 L L L L L L L L L L L L L
43 V V V
M0.1
G0.1
V V
E0.3
V V V V V
M0.0
G0.0
E0.0
V
A0.4
V V
E0.8
44 V V V
del0.1
E0.1
V
A0.1
V V V V V V
A0.0
del0.0
E0.0
V V V
45 D D
A0.3
D D D D D D D D
A0.0
D D D
46 F F F F F F F F F F F F F
47 S S S
P0.1
S S
C0.3
S S S S S
C0.0
P0.0
S S S
48 Q Q
R0.3
Q Q Q Q Q Q Q Q
R0.0
Q Q Q
49 F F F F
S0.1
F
Y0.3
F F F F F
S0.0
Y0.0
F F F
50 S
P0.7
S S
P0.1
L0.1
S S
C1.3
S S S S S
C0.1
P0.1
L0.0
S
Y0.3
S S
51 R R
K0.5
R
G0.3
K0.1
R R
K0.3
R R R R
K1.9
R
K0.2
G0.1
R R R
52 G G
A0.3
G G G
R0.3
G G G G G
A0.0
R0.0
G G G
53 I
V14.5
L13.3
S6.1
T3.3
A1.6
N1.2
P0.9
F0.2
H0.2
N
D3.5
H1.9
T1.6
S0.8
K0.5
Q0.3
P0.3
E0.3
S
N3.9
N
D5.0
K2.6
S1.0
E0.4
H0.2
T0.1
I0.1
S
I2.0
N1.6
G0.3
T
N29.5
S0.8
P0.8
S T I
S58.8
N2.0
S
T
N
I
V2.2
L2.0
D1.9
K0.8
H0.4
A0.3
P0.2
E0.1
F0.0
Q0.0
G0.0
S
T
N
I
L4.5
V3.5
D1.0
K1.0
P0.7
H0.3
E0.3
S
T
N
I
S
T
N
I
V1.4
A0.7
E0.7
54 T
S6.1
N1.8
T
N1.8
A0.5
S0.5
P0.3
T
Y2.8
S1.3
H0.3
N0.3
P0.1
Y
H26.0
N1.0
D0.9
T0.6
P0.3
C0.1
R0.1
S
T1.0
T
N0.8
A T N
T56.9
T
A
S
N
Y
H7.4
D0.2
P0.1
C0.0
R0.0
T
A
S
N
Y
H8.9
D1.0
T
A
S
N
Y
H2.0
T
A
S
N
Y
H7.6
55 R
S0.2
R
H0.3
H
R6.3
Q6.2
K2.6
S0.5
D0.2
N0.2
R
K0.1
R R
Q0.8
R R R
H2.0
R
H
Q1.5
K0.6
S0.1
D0.0
N0.0
R
H
Q1.3
K0.7
R
H
R
H
A0.7
Q0.7
56 V V V V V
M0.3
V V V V V
M0.0
V V V
M0.7
57 S
P0.2
S
P0.3
S
F0.3
Y0.1
S
P0.5
S S
F0.8
S S S
P5.8
S
P0.3
F0.1
Y0.0
S
C0.3
S S
P0.6
58 W W W
C0.3
L0.1
W
C0.1
W W W W W W
C0.1
L0.0
W W W
59 P P P
A0.1
P
T0.1
P
A0.3
P P P P P
A0.1
T0.0
P P P
60 K K K K
T0.1
R0.1
K K K K K K
T0.0
R0.0
K
R0.3
K K
61 F F F F
I0.1
F F F F F
I1.9
F
I0.1
F
C0.3
Y0.3
F F
62 A A
P0.3
A A A A A A A A
P0.0
A A A
63 V
I0.2
V
L0.3
V V V V V V V V
I0.0
L0.0
V V V
64 P P P
T0.1
P P P P P P P
T0.0
P P P
65 N N N N
D0.1
N N N N N N
D0.0
N N N
66 L L L
P0.1
L L L L L L L
P0.0
L L L
67 Q Q Q Q Q Q Q Q Q Q Q Q
P1.7
Q
68 S S S S
A0.1
S S S S S S
A0.0
S
A0.3
S S
69 L L L L L
I0.3
L L L L L
I0.0
L L L
70 T T T T T T T T T T T T T
71 N N N N N N N N N
K1.9
N
K0.0
N N N
D0.6
72 L L L L L L L L L
H1.9
L
H0.0
L L L
73 L
F0.2
P0.2
L L
W0.1
L L L L L L L
F0.0
W0.0
P0.0
L L L
74 S S S S S S S S S S S S S
75 S
A0.2
S
T0.5
S
T1.0
P0.1
S S
T0.3
S S S S
A1.9
S
T0.3
A0.1
P0.0
S S S
76 N
D0.9
K0.2
N
D20.8
N
D1.8
K0.1
N
D4.0
S0.5
G0.1
N
D1.6
H0.3
N N N N
D1.9
N
D4.7
S0.1
K0.1
H0.0
G0.0
N
D3.3
N
D6.9
N
D1.9
77 L
M0.2
L L
F0.1
L L L L L L L
F0.0
M0.0
L
W0.3
L L
78 S S
P0.3
S
T0.6
S
T0.8
A0.4
C0.4
S
A0.3
S S S S S
T0.4
A0.1
C0.1
P0.0
S
T0.7
S
T3.4
S
T2.5
79 W W W
R0.1
W W W W W W W
R0.0
W W W
80 L
V0.2
L L
V0.6
L
I0.2
L
Q0.3
L L L L
V1.9
L
V0.2
I0.1
Q0.0
L
I10.4
V2.9
L L
I6.4
V1.3
81 S S S S
A0.1
S S S S S S
A0.0
S S S
82 L
R0.4
L L L L L L L
S7.4
L L
S0.1
R0.1
L
M1.0
L L
M1.9
83 D D D D D D D D D D D D D
84 V
A0.2
M0.2
V V
I0.4
V
A0.2
V V V V V V
A0.1
I0.1
M0.0
V V V
85 S S
T0.3
S
T0.6
F0.1
P0.1
S
C0.2
A0.1
S
P0.3
S S S S S
T0.2
C0.1
P0.1
A0.0
F0.0
S
A0.3
S
A1.7
S
A1.9
86 A A A A A A A A A A A
S0.6
A A
87 A
R0.2
A A A A A A A A A
R0.0
A A
E1.7
A
88 F F F
L0.1
F
R0.1
V0.1
F
L0.3
Y0.3
F F F F
S1.9
F
L0.1
S0.0
R0.0
Y0.0
V0.0
F F F
89 Y
C0.2
Y Y Y
H0.1
N0.1
Y
F0.3
Y Y Y Y Y
F0.0
H0.0
C0.0
N0.0
Y Y Y
90 H H H H
D0.1
H H H H H H
D0.0
H
Y0.6
H H
91 I
L0.2
L
I4.5
I
L20.6
T0.1
L
I6.9
L
I7.2
L
I1.5
I L L
I1.9
L
I
T0.0
L
I
L
I
L
I
92 P P P P
T0.1
P P P P P P
T0.0
P P P
93 L L
M0.3
L L L L L L L L
M0.0
L L L
94 H H H H
R0.2
P0.1
H H H H H H
R0.1
P0.0
H
Y0.3
H H
95 P P P
A0.1
P
L0.1
P P
H0.8
P P P P
A0.0
H0.0
L0.0
P P P
96 A
T0.2
A A A A A A A A A
T0.0
A
S0.3
V0.3
A A
97 A A A
S0.4
A
T0.2
S0.1
A
V0.3
A
G0.8
A A A
T1.9
A
S0.1
T0.1
G0.0
V0.0
A
T0.3
A A
S0.5
98 M M
I0.4
M M M M M M
R7.4
M M
I0.1
R0.1
M M
L1.2
M
99 P P P P P P P P P P P P P
100 H H H
P0.3
D0.1
R0.1
H H H H H
S3.7
H H
P0.1
S0.0
D0.0
R0.0
H H H
101 L L
P0.2
L
F0.1
P0.1
L L L L L
P3.7
L L
P0.1
F0.0
L L L
102 L L L L L L L L
F3.7
L L
F0.0
L L L
103 I
V2.1
V
A0.2
I0.2
V
G0.3
I0.1
V V
D0.3
V V V
A3.7
V
I1.9
V
I
A0.1
G0.1
D0.0
V
I
V
I
V
I
104 G G G
C0.1
G G G G G
C3.7
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107 G G G G G G G G G G G G G
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117 S
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118 N
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119 S
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120 R
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121 I
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127 G
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128 T
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176 S S S
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177 P P P P P P P P P P P
T0.2
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178 F
S0.2
F F F F F F F F F
S0.0
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179 L L L L L L L L L L L L L
180 L L
W0.2
L
M0.1
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M0.1
L L L L L L
M0.1
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M31.7
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181 A
S0.2
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182 Q Q Q
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183 F F F F
L0.2
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184 T T T
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185 S
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186 A
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187 I
L1.6
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188 C
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189 S S S
L0.1
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190 V
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191 V
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192 R
S0.2
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193 R
M0.2
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K0.3
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K0.1
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194 A
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T0.7
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S0.1
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A A A
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S0.4
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195 F F F
S0.1
F F F F F F F
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196 P P
S0.2
P P
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197 H
R0.2
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P0.2
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P0.0
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198 C C C
W0.1
C C C C C C C
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199 L
V0.4
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L L L L L L L
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200 A A A
V0.1
A A A A A A A
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V1.1
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201 F F F F
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202 S
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S S
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203 Y Y Y
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204 M
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205 D D
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206 D D
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207 V
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208 V V V V
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209 L L
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210 G G G G G G G G G G G G G
211 A A
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A A A A A A
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212 K
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213 S
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214 V
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215 Q
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216 H H H H H H H H H H H H H
217 R
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218 E
D0.6
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219 S
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220 L L
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221 Y
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222 T
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223 A
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224 V
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225 T
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226 N
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227 F F
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228 L L L
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L L L L L L L
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229 L
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230 S
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231 L L
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232 G G G G G G G G G G G G G
233 I
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234 H H
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235 L L
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236 N N
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N N N N N N N N
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237 P
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238 N
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239 K
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240 T
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T
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241 K
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242 R
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R R R W
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243 W W W W W W W W W W W
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244 G G G G G G G G G G G G G
245 Y Y
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246 S
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247 L L L
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248 N
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249 F
S0.2
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250 M
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251 G
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G G G G G G G G G
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252 Y Y
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253 I
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254 I I
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255 G G G G
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256 S
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257 W
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258 G G G G G G G G G G G
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G G
259 T
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260 L L
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261 P P P P P P P P P P P P P
262 Q Q
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263 D
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264 H H H H H H H H H H H H H
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265 I I I I I I I I I I I I I
266 V
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267 Q
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D0.1
K0.0
E0.0
Q
H
M
L
K0.7
R0.3
Q
H
M
L
Q
H
M
L
268 K K
N0.6
K
R0.2
K
T0.1
K
R0.4
K K K K K
N0.1
R0.1
T0.0
K
R0.3
K K
269 I
L2.5
I
L2.0
F0.3
T0.3
V0.3
I
L43.0
S0.2
P0.2
I
L2.6
I I
L5.7
I I I I
L12.9
F0.0
S0.0
T0.0
P0.0
V0.0
I
L9.4
I
L10.5
I
L8.3
V0.6
270 K
T0.5
R0.2
K
T1.1
R1.1
N0.6
Q0.3
K
Q0.5
A0.3
R0.3
E0.3
M0.2
T0.2
K
R0.4
T0.1
K
Q1.7
S0.4
T0.4
R0.4
K K K K
R25.0
N2.1
K
R0.9
T0.4
Q0.3
A0.1
N0.1
E0.1
S0.0
M0.0
K
R1.0
S0.3
Q0.3
K
R3.5
K
R0.6
271 H
Q2.2
N2.0
C1.7
D1.0
S0.2
R0.2
M
Q20.7
L19.5
S4.6
I1.1
T0.9
V0.9
H0.3
R0.3
Q
H3.6
N1.1
E0.6
K0.5
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L0.3
M0.2
D0.2
E
D16.8
Q0.7
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H0.1
D
N1.3
H0.4
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D
E42.0
A1.1
Q D
N3.7
Q
K14.6
H2.1
Q
D
H
M
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L2.8
N0.8
S0.7
K0.4
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R0.2
I0.2
A0.1
T0.1
V0.1
Q
D
H
M
E
L2.5
A0.4
S0.4
T0.4
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Q
D
H
M
E
L5.4
S1.8
Q
D
H
M
E
N1.3
L1.3
272 C C
W0.9
C
S0.2
C C C
L1.1
C C C C
W0.1
S0.0
L0.0
C C C
273 F F
L0.3
F
V0.2
F F F F F F F
L0.0
V0.0
F F F
274 R
K0.7
R
K1.7
T0.6
R
Q0.5
R
K0.9
R
G0.4
R R R R R
K0.6
Q0.1
T0.1
G0.0
R
K0.7
G0.3
R R
I0.6
K0.6
275 K
Q0.5
E0.2
L0.2
K K
Q0.2
T0.2
I0.2
K K
N0.9
K K K K K
Q0.1
N0.1
T0.0
I0.0
E0.0
L0.0
K
Q0.3
K K
276 L L
I0.6
L
I0.2
L
I0.3
P0.1
L L
V2.3
L L L
I2.1
L
I0.2
V0.1
P0.0
L L L
277 P P P P P P P P P P P P P
278 V
I4.0
L0.2
V
I0.6
A0.3
G0.3
V
I20.8
T1.1
L0.6
C0.3
M0.2
V
I5.5
C0.1
V
I0.4
V V V V
I6.2
V
I7.9
T0.3
L0.2
C0.1
A0.0
M0.0
G0.0
V
I12.8
T0.7
L0.4
V
I12.2
V
I11.0
T0.6
L0.6
279 N
R0.2
N
H0.6
N
S0.3
C0.3
H0.2
N
H3.0
R0.4
D0.1
N
T0.4
N N N N N
H0.9
R0.2
S0.1
C0.1
T0.0
D0.0
N
K0.4
N
H2.0
N
280 R
S0.2
P0.2
R R
S0.2
R R R R R R
K2.1
R
S0.1
K0.0
P0.0
R R R
281 P P
T0.3
P P
H0.1
P
H0.4
P P P P P
H0.1
T0.0
P P P
282 I
A0.2
V0.2
I I
V1.2
I
M0.1
V0.1
I
L1.3
V0.4
I I I I
V20.8
I
V0.8
L0.1
A0.0
M0.0
I
V0.4
I I
283 D D D D D D D D D D D D D
284 W W
G0.3
W W W W W W W W
G0.0
W W W
Y0.7
285 K
R0.2
K K
E0.3
K K K K K K K
E0.1
R0.0
K K K
286 V V
L0.3
V V
F0.1
V
A0.4
V V V V V
A0.0
F0.0
L0.0
V V V
287 C C C
R0.2
C
W0.4
R0.1
C
R0.4
V0.4
C
W1.1
C C C C
W0.2
R0.1
V0.0
C C C
288 Q Q
P0.6
Q Q Q
P0.4
Q Q Q Q Q
P0.1
Q Q Q
289 R
K0.2
R
Q0.6
R
K0.2
R R
G0.9
R
S1.1
R R R R
Q0.1
K0.1
G0.1
S0.0
R R R
290 I
L0.2
V0.2
I
L0.9
I
L0.3
I
L0.3
N0.1
I I
L1.1
I I I I
L0.4
N0.0
V0.0
I
M1.1
I I
M1.6
291 V
A0.2
V
A0.9
S0.3
G0.3
V
G0.2
V
G0.1
V
A0.4
V T V S
V4.2
T2.1
V
S
T
A0.2
G0.1
V
S
T
V
S
T
V
S
T
292 G
S0.2
G G G G G G G G G
S0.0
G G G
293 L
F0.2
P0.2
L
P0.3
L
I0.2
L
I0.2
L L L L L L
I0.1
P0.1
F0.0
L L L
F0.8
294 L L
W0.3
L L
W0.3
P0.2
L L L L L
W2.1
L
W0.2
P0.0
L L L
295 G G G G G G G G G G G
A1.1
G G
296 F F F F F F F F
L3.7
F F
L0.0
F F F
297 A A
V0.3
A
V0.5
A
V0.2
A A A A A A
V0.2
A A A
298 A A
G0.3
A
V0.2
A A A A A A A
G0.0
V0.0
A
V0.6
A A
299 P
S0.2
P P P P P P P P P
S0.0
P P P
300 F F
L0.3
F F F F F F F F
L0.0
F F F
301 T T
P0.3
T T
S0.2
T T T T T T
S0.0
P0.0
T T T
302 Q Q Q Q Q Q Q Q Q Q Q
R0.6
Q Q
303 C C
W0.3
C C C C C C C C
W0.0
C
W0.6
C C
304 G G G G G G G G G G G G G
305 Y Y
F0.3
Y
F0.3
T0.2
Y
F0.3
Y Y Y Y Y Y
F0.2
T0.0
Y
F0.6
Y Y
306 P P P
A0.3
L0.2
P P P P P P P
A0.1
L0.0
P P P
307 A A A A A A A A A A A A A
308 L L L
F0.2
L L L L L L L
F0.0
L L L
309 M
K1.0
M
K4.0
L0.9
M
K1.7
L1.4
S0.2
V0.2
M
K12.4
L1.4
M
L0.5
M M M M M
K4.4
L0.9
S0.0
V0.0
M
K5.2
M
K8.3
M
K0.9
310 P P P P P P P P P P P P P
311 L L L
I0.5
L L
I2.3
R0.5
L
I1.1
L L L L
I0.4
R0.0
L L L
312 Y
C0.5
Y
S0.3
Y
S0.2
Y Y Y
H1.1
Y Y Y Y
S0.1
C0.1
H0.0
Y
D0.6
Y Y
313 A
S0.2
A
S0.3
T0.3
A
T0.5
S0.3
A
S0.2
T0.2
A
S0.9
T0.5
T
A34.1
N5.7
A A A A
T
S0.3
N0.2
A
T
A
T
A
T
314 C
S0.5
C
S0.6
C
S0.3
C
H0.2
C
S0.9
C C C C
S2.1
C
S0.4
H0.0
C C C
315 I I
M0.3
K0.3
I I I
T5.9
V0.9
I I I I I
T0.5
V0.1
M0.0
K0.0
I I I
316 Q Q
H1.7
Q
H4.6
S0.2
N0.2
Q
H0.6
Q
H1.8
T
S2.3
Q T Q
H4.3
Q
T
H1.9
S0.1
N0.0
Q
T
H1.1
Q
T
H4.1
Q
T
H1.7
317 A
S0.5
T0.2
A
S2.3
T0.6
S
A34.6
K0.3
P0.3
T0.2
D0.2
S
A4.4
Y0.3
T0.2
S
A1.4
Y0.5
A
T1.1
A A A
T2.1
A
S
T0.3
K0.1
P0.1
Y0.1
D0.0
A
S
V0.6
A
S
A
S
318 K
R6.4
K
R1.1
Q0.3
K
R0.5
H0.3
K
R10.9
K
R2.3
Q0.5
G0.5
K K K
N3.7
K K
R4.4
H0.1
Q0.1
N0.0
G0.0
K
R5.1
K K
R3.4
319 Q
R0.7
K0.5
Q
R1.1
K0.9
L0.3
Q
K1.1
R0.9
L0.2
Q
P0.2
R0.2
Q
K0.5
Q Q Q Q
R2.1
Q
R0.6
K0.5
L0.1
P0.0
Q
R1.1
Q
R2.0
Q
320 A
V0.5
T0.2
A A A
T0.3
A A A A A A
T0.1
V0.1
A A A
321 F
S1.5
Y0.2
F F F F F F F F F
S0.2
Y0.0
F F F
322 T
L1.3
I0.8
F0.5
S0.5
T
A0.3
S0.3
I0.3
V0.3
T
S0.5
A0.2
I0.2
T
S0.6
I0.2
T
L1.4
I0.9
V T V T T
V
S0.4
I0.3
L0.3
A0.1
F0.1
T
V
S0.6
I0.6
T
V
T
V
I0.9
323 F F F
S0.2
L0.2
F F F F F F F
S0.0
L0.0
F F F
324 S
F0.8
P0.8
L0.3
S S
P0.2
S
P0.2
S S S S S S
P0.2
F0.1
L0.0
S S S
325 P
L0.3
P
L0.6
T0.3
P
S2.6
L0.5
T0.2
P
T0.6
Q0.3
L0.3
S0.2
P
Q0.5
L0.5
P P P P P
S0.7
L0.4
T0.2
Q0.1
P P P
S1.7
326 T
P0.3
T
I0.9
V0.3
T
I0.8
V0.3
T
P1.2
I1.1
T
I0.5
T T T T
I2.1
T
I0.7
P0.4
V0.1
T
I1.7
T T
327 Y
F0.3
H0.3
Y Y
C0.2
Y
C0.2
Y Y Y Y Y Y
C0.1
F0.0
H0.0
Y
F0.6
Y Y
328 K
Q0.3
K
R0.3
K
R0.6
K K K K K K K
R0.2
Q0.0
K K K
329 A
T0.5
G0.3
A
T1.4
S0.3
A
T2.6
V1.5
S0.3
M0.2
P0.2
A
T1.9
V0.6
A
T2.7
A
T1.1
A A A
V2.1
A
T1.8
V0.6
S0.1
M0.0
P0.0
G0.0
A
T1.1
A
T2.0
A
T0.9
330 F
L0.3
F
L0.3
F
S0.2
L0.2
F F F F F F F
L0.1
S0.0
F F F
331 L L L
R0.2
L
Q0.2
L L L L L L
Q0.0
R0.0
L L L
332 S
R6.5
N4.3
H0.3
C0.3
K0.3
S
R19.2
N15.8
H3.4
T1.1
C1.1
Y0.3
C
Y1.8
R1.4
K0.3
S0.2
W0.2
C
Y3.5
R1.4
S0.3
N0.2
C
Y1.8
F0.5
S0.5
C C C
R7.4
C
S4.3
R2.1
C
S
R4.7
N3.0
Y1.6
H0.5
T0.2
K0.1
F0.0
W0.0
C
S
R5.7
N4.0
Y2.3
K1.1
C
S
R4.3
C
S
Y2.7
R0.9
333 K
Q8.6
T6.7
N2.2
E0.5
A0.3
H0.3
D0.3
K
N8.4
Q7.5
H0.9
T0.6
E0.3
K
Q10.6
N1.5
T0.6
D0.3
E0.3
A0.2
K
Q1.3
N0.3
H0.2
T0.2
E0.2
K
Q7.8
T6.5
N2.8
K
Q22.7
H1.1
D1.1
K K
Q7.4
H3.7
K
Q4.3
N2.1
K
Q7.3
N2.3
T1.9
H0.3
D0.2
E0.2
A0.1
K
Q8.1
T3.5
E1.2
A0.6
N0.6
K
Q2.1
N2.1
K
Q8.8
N2.7
H0.9
334 Q
L0.3
Q
L0.6
Q
L0.3
Q Q Q Q Q Q Q
L0.2
Q
L0.6
Q Q
335 Y Y Y Y Y Y Y Y Y Y Y Y Y
336 M
L3.0
V0.5
L
M3.2
S0.6
R0.3
V0.3
L
M8.0
Q0.6
I0.2
R0.2
L
M5.5
A0.3
S0.2
R0.2
L
M16.9
S0.5
R0.5
M M
L5.6
M
L11.1
M
L25.5
S4.3
A2.1
M
L
S0.3
Q0.2
R0.2
A0.1
V0.1
I0.0
M
L
R0.6
M
L
Q2.1
M
L
Q0.9
I0.9
337 N
D2.1
H0.5
T0.5
N
T9.2
H2.6
D1.1
Y0.3
N
H19.6
T0.9
N
T3.5
H1.3
Y0.2
N
T2.7
D2.3
H0.5
Y0.5
N
H8.0
N N
T3.7
N
T6.4
N
H6.4
T3.0
D0.7
Y0.1
N
H14.7
T2.8
D0.6
N
T4.1
N
H23.5
T2.6
338 L L L
P0.2
L
F0.5
L L L L L L
F0.1
P0.0
L L L
339 Y Y
S0.3
T0.3
Y Y Y
F0.9
Y Y Y Y Y
F0.1
S0.0
T0.0
Y Y Y
340 P P
S0.3
P P P P P P P P
S0.0
P P P
341 V V V
G0.2
V
D0.2
V V
A1.1
V V V V
A0.0
D0.0
G0.0
V V V
342 A
S0.3
A
S0.3
T0.3
V0.3
A
T0.5
V0.3
G0.2
A
V0.3
T0.2
A
V0.5
A A A A
V4.3
A
V0.3
T0.2
S0.1
G0.0
A
T1.1
V0.6
A A
V1.8
343 R R R R
K0.2
E0.2
R R R R R R
K0.0
E0.0
R R R
344 Q Q Q
R0.2
Q Q
K0.5
Q Q Q Q Q
K0.0
R0.0
Q Q Q

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