Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

PI Resistance Notes

Last updated on Feb 28, 2014
Position
 
ConsAAFPV/r
 
IDV/r
 
NFV
 
SQV/r
 
LPV/r
 
ATV/r
 
TPV/r
 
DRV/r
 
50IL-5-5-5-5-1060-5-10
88NS-101560150600-5
10LI00000000
10LR00000000
10LV00000000
10LY00000000
13IV00000000
20KI001000000
20KM00000000
20KR00000000
20KT551000500
20KV00500000
23LI001500000
24LI101010101010-50
24LF55555500
24LM55555500
30DN006000000
33LV00000000
33LI00000000
35EG00500050
36MI00000000
36ML00000000
36MV00000000
36MT00000000
43KT000000100
46MI1010205101050
46ML10102051010100
46MV101020551050
48GV0103060103000
48GM0103060103000
48GA0103060101000
48GS0103060101000
48GT0103060101000
48GQ0103060101000
48GL0103060101000
53FL0001501000
53FY00000000
54IS101520151015200
54IT101520151015200
54IV101520151515200
54IA101520151015200
58QE005005150
63LP00000000
71AT00000000
71AV00000000
71AI50550500
71AL50550500
73GC510151551000
73GS510151551000
73GT510151551000
73GA510151551000
73GV55555500
74TS001500000
77VI00000000
82VA15303015301500
82VI00000000
82VS103030102525250
82VT103030102525450
82VM103030102510100
82VL151010101010450
82VC101010101010100
83ND0101010010200
85IV00000000
88ND003050500
88NT0030001500
88NG0030001500
89LI00000000
89LM00000000
89LT00000000
90LM20306040152500
93IL00000000
10LF10101005005
11VI50000005
11VL50000005
33LF1005055105
74TP10101510510205
89LV55500005
47IV30151501553010
47IA60153006053010
84IC6060606030603010
32VI30151501515515
82VF303030103015015
84IV6060606030603015
50IV6001515300-520
54IL601020151515-1020
54IM6015201515152020
76LV60300-530-5-520
84IA6060606060606030

There are 46 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.
Drug NameCombination RuleScore
ATV/r46ILV+82ATSFMCL10
ATV/r46ILV+90M10
ATV/r53L+90M10
ATV/r54AVSTLM+82ATSFMCL10
ATV/r73STCA+90M10
ATV/r82ATSFMCL+90M10
DRV/r32I+47VA5
DRV/r32I+54ML10
DRV/r47VA+54ML5
FPV/r10F+82ATSLCM10
FPV/r32I+82ATSLCM10
FPV/r33F+82ATSLCM10
FPV/r46ILV+82ATSLCM10
FPV/r47V+82ATSLCM10
FPV/r54AVST+82ATSLCM10
FPV/r89V+82ATSLCM10
IDV/r24IFM+82ATSFMCL10
IDV/r32I+47VA15
IDV/r32I+54M15
IDV/r46IL+76V10
IDV/r46ILV+82ATSFMCL10
IDV/r46ILV+90M10
IDV/r47VA+54M15
IDV/r54AVSTLM+82ATSFMC10
IDV/r73STCA+90M10
LPV/r32I+47V10
LPV/r32I+54ML10
LPV/r46IL+76V10
LPV/r46ILV+82AFSTMC5
LPV/r47V+54ML10
LPV/r54VSTAML+82AFSTMC10
LPV/r82AFSTMC+24IFM10
LPV/r90M+82AFSTMC5
LPV/r90M+84V5
NFV46IL+76V10
NFV46ILV+82AFSTMC10
NFV54VSTAML+82AFSTMC10
SQV/r53L+90M10
SQV/r54AVSTLM+82ATSFMC10
SQV/r54AVSTLM+90M5
SQV/r73STCA+90M10
SQV/r82ATSFMC+90M10
TPV/r74P+47VA10
TPV/r74P+84VC10
TPV/r83D+47VA10
TPV/r83D+84VC10