Resistance Matrix

Resistance Mutation Comments

Resistance Mutation Scores

Drug Summaries

Position	Cons	AA	FPV/r	IDV/r	NFV	SQV/r	LPV/r	ATV/r	TPV/r	DRV/r
10	L	F	10	5	10	0	5	0	0	0
10	L	I	0	0	5	0	0	0	0	0
10	L	R	0	0	5	0	0	0	0	0
10	L	V	0	0	5	0	0	0	0	0
10	L	Y	0	0	5	0	0	0	0	0
11	V	I	5	0	0	0	0	0	0	0
11	V	L	5	0	0	0	0	0	0	0
13	I	V	0	0	0	0	0	0	0	0
20	K	I	0	0	10	0	0	0	0	0
20	K	M	0	0	0	0	0	0	0	0
20	K	R	0	0	0	0	0	0	0	0
20	K	T	0	0	10	0	0	0	0	0
20	K	V	0	0	0	0	0	0	0	0
23	L	I	0	0	15	0	0	0	0	0
24	L	I	5	10	5	5	10	5	-5	0
24	L	F	0	0	0	0	0	0	0	0
30	D	N	0	0	60	0	0	0	0	0
32	V	I	30	15	15	0	15	15	5	20
33	L	F	10	0	5	0	5	5	5	5
33	L	V	0	0	0	0	0	0	0	0
33	L	I	0	0	0	0	0	0	0	0
35	E	G	0	0	5	0	0	0	5	0
36	M	I	0	0	0	0	0	0	0	0
36	M	L	0	0	0	0	0	0	0	0
36	M	V	0	0	0	0	0	0	0	0
36	M	T	0	0	0	0	0	0	0	0
43	K	T	0	0	0	0	0	0	10	0
46	M	I	10	10	15	0	10	10	0	0
46	M	L	10	10	15	0	10	10	0	0
46	M	V	5	5	10	5	5	5	0	0
47	I	V	30	10	15	0	15	5	20	10
47	I	A	60	15	30	0	60	5	20	10
48	G	V	0	10	30	60	10	30	0	0
48	G	M	0	10	30	60	10	30	0	0
48	G	A	0	10	15	30	10	10	0	0
48	G	S	0	10	15	30	10	10	0	0
48	G	T	0	10	15	30	10	10	0	0
48	G	Q	0	10	15	30	10	10	0	0
48	G	L	0	10	15	30	10	10	0	0
50	I	V	60	0	10	5	20	0	-5	20
50	I	L	-5	-5	-5	-5	-5	60	-5	-5
53	F	L	0	0	0	10	0	5	0	0
53	F	Y	0	0	0	0	0	0	0	0
54	I	L	60	10	15	10	15	15	-10	20
54	I	M	60	10	15	10	15	15	15	20
54	I	S	10	15	15	15	10	15	15	0
54	I	T	10	15	15	15	10	15	15	0
54	I	V	10	15	15	15	10	15	15	0
54	I	A	10	15	15	15	10	15	15	0
58	Q	E	0	0	5	0	0	5	10	0
63	L	P	0	0	0	0	0	0	0	0
71	A	T	0	0	5	0	0	0	0	0
71	A	V	0	0	5	0	0	0	0	0
71	A	I	5	0	5	5	0	5	0	0
71	A	L	5	0	5	5	0	5	0	0
73	G	C	5	5	10	10	5	10	0	0
73	G	S	5	5	10	10	5	10	0	0
73	G	T	5	5	10	10	5	10	0	0
73	G	A	5	5	10	10	5	10	0	0
74	T	P	3	0	10	0	0	5	20	0
74	T	S	5	0	15	0	0	0	0	0
76	L	V	60	30	0	-5	30	-5	-5	20
77	V	I	0	0	0	0	0	0	0	0
82	V	A	10	30	30	10	25	15	0	0
82	V	F	30	30	30	0	25	15	0	15
82	V	I	0	0	0	0	0	0	0	0
82	V	S	10	30	30	10	25	15	15	0
82	V	T	10	30	30	10	25	15	40	0
82	V	M	10	15	10	10	10	10	10	0
82	V	L	10	10	10	10	10	10	40	0
82	V	C	10	10	10	10	10	10	10	0
83	N	D	0	5	5	5	0	5	20	0
84	I	A	60	60	60	60	30	60	30	10
84	I	V	60	30	60	60	15	40	30	10
84	I	C	30	30	60	60	15	30	15	10
85	I	V	0	0	0	0	0	0	0	0
88	N	D	0	0	30	5	0	10	0	0
88	N	S	-10	10	60	5	0	60	0	-5
88	N	T	0	0	30	0	0	10	0	0
88	N	G	0	0	30	0	0	10	0	0
89	L	V	5	5	5	0	0	0	0	5
89	L	I	0	0	0	0	0	0	0	0
89	L	M	0	0	0	0	0	0	0	0
89	L	T	0	0	0	0	0	0	0	0
90	L	M	20	20	60	40	10	20	0	0
93	I	L	0	0	0	0	0	0	0	0

There are 80 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.

Drug Name	Combination Rule	Score
ATV/r	(10IVFRY AND 90M)	5
ATV/r	(46ILV AND 82ATS AND 10IFVRY)	5
ATV/r	(46ILV AND 82ATS AND 71VTLI)	5
ATV/r	(46ILV AND 82ATS)	5
ATV/r	(53L AND 90M)	5
ATV/r	(54AVSTLM AND 82ATS AND 10IFVRY)	5
ATV/r	(54AVSTLM AND 82ATS AND 71VTLI)	5
ATV/r	(54AVSTLM AND 82ATS)	5
ATV/r	(71VTLI AND 90M)	5
ATV/r	(73STCA AND 90M)	10
DRV/r	(32I AND 47VA AND 54ML AND 10F)	5
DRV/r	(32I AND 47VA AND 54ML AND 11IL)	5
DRV/r	(32I AND 47VA AND 54ML AND 33F)	5
DRV/r	(32I AND 47VA AND 54ML AND 73SCTA)	5
DRV/r	(32I AND 47VA AND 54ML AND 74P)	5
DRV/r	(32I AND 47VA AND 54ML AND 89V)	5
DRV/r	(32I AND 47VA AND 54ML)	10
DRV/r	(32I AND 54ML AND 84VA AND 10F)	5
DRV/r	(32I AND 54ML AND 84VA AND 11IL)	5
DRV/r	(32I AND 54ML AND 84VA AND 33F)	5
DRV/r	(32I AND 54ML AND 84VA AND 73SCTA)	5
DRV/r	(32I AND 54ML AND 84VA AND 74P)	5
DRV/r	(32I AND 54ML AND 84VA AND 89V)	5
DRV/r	(32I AND I54ML AND 84VA)	10
FPV/r	(46ILV AND 82ATS AND 10IFVRY)	5
FPV/r	(46ILV AND 82ATS AND 71VTLI)	5
FPV/r	(46ILV AND 82ATS)	5
FPV/r	(54AVSTLM AND 82ATS AND 10IFVRY)	5
FPV/r	(54AVSTLM AND 82ATS AND 71VTLI)	5
FPV/r	(54AVSTLM AND 82ATS)	5
IDV/r	(32I AND 47VA AND 54ML AND 10F)	10
IDV/r	(32I AND 47VA AND 54ML AND 73SCTA)	10
IDV/r	(32I AND 47VA AND 54ML AND 89V)	5
IDV/r	(32I AND 47VA AND 54ML AND 90M)	10
IDV/r	(32I AND 47VA AND 54ML)	10
IDV/r	(32I AND 47VA)	10
IDV/r	(32I AND 54ML AND 84VA AND 10F)	10
IDV/r	(32I AND 54ML AND 84VA AND 73SCTA)	10
IDV/r	(32I AND 54ML AND 84VA AND 89V)	5
IDV/r	(32I AND I54ML AND 84VA AND 90M)	10
IDV/r	(32I AND I54ML AND 84VA)	10
IDV/r	(46IL AND 76V)	10
IDV/r	(46ILV AND 90M)	10
IDV/r	(54VSTA AND 82AFST AND 10F)	10
IDV/r	(54VSTA AND 82AFST AND 10IVR)	5
IDV/r	(54VSTA AND 82AFST AND 24I)	10
IDV/r	(54VSTA AND 82AFST AND 46ILV)	10
IDV/r	(54VSTA AND 82AFST AND 90M)	10
IDV/r	(73STCA AND 90M)	10
IDV/r	(90M AND 84V)	10
LPV/r	(32I AND 47VA AND 54ML AND 10F)	10
LPV/r	(32I AND 47VA AND 54ML AND 33F)	10
LPV/r	(32I AND 47VA AND 54ML AND 73SCTA)	10
LPV/r	(32I AND 47VA AND 54ML AND 89V)	5
LPV/r	(32I AND 47VA AND 54ML AND 90M)	10
LPV/r	(32I AND 47VA AND 54ML)	10
LPV/r	(32I AND 47VA)	10
LPV/r	(32I AND 54ML AND 84VA AND 10F)	10
LPV/r	(32I AND 54ML AND 84VA AND 33F)	10
LPV/r	(32I AND 54ML AND 84VA AND 73SCTA)	10
LPV/r	(32I AND 54ML AND 84VA AND 89V)	5
LPV/r	(32I AND I54ML AND 84VA AND 90M)	10
LPV/r	(32I AND I54ML AND 84VA)	10
LPV/r	(46IL AND 76V)	10
LPV/r	(54VSTA AND 82AFST AND 10F)	10
LPV/r	(54VSTA AND 82AFST AND 10IVR)	5
LPV/r	(54VSTA AND 82AFST AND 24I)	10
LPV/r	(54VSTA AND 82AFST AND 46ILV)	10
LPV/r	(54VSTA AND 82AFST AND 90M)	10
LPV/r	(90M AND 84V)	5
SQV/r	(10IVFRY AND 90M)	5
SQV/r	(46ILV AND 82ATS AND 10IFVRY)	5
SQV/r	(46ILV AND 82ATS AND 71VTLI)	5
SQV/r	(46ILV AND 82ATS)	5
SQV/r	(53L AND 90M)	5
SQV/r	(54AVSTLM AND 82ATS AND 10IFVRY)	5
SQV/r	(54AVSTLM AND 82ATS AND 71VTLI)	5
SQV/r	(54AVSTLM AND 82ATS)	5
SQV/r	(71VTLI AND 90M)	5
SQV/r	(73STCA AND 90M)	10