Resistance Matrix

Resistance Mutation Comments

Resistance Mutation Scores

Drug Summaries

Position	Cons	AA	3TC	FTC	ABC	AZT	D4T	DDI	TDF
65	K	R	30	30	45	-10	30	45	45
66	K	insert	30	30	45	45	45	45	45
67	D	insert	30	30	45	45	45	45	45
68	S	insert	30	30	45	45	45	45	45
69	T	insert	30	30	45	45	45	45	45
70	K	insert	30	30	45	45	45	45	45
71	W	insert	30	30	45	45	45	45	45
70	K	G	10	10	15	-10	0	15	25
70	K	E	10	10	15	-10	0	15	25
65	K	N	15	15	15	0	15	15	15
115	Y	F	0	0	45	0	0	0	15
151	Q	M	15	15	60	60	60	60	15
215	T	F	5	5	15	45	45	15	15
215	T	Y	5	5	15	45	45	15	15
66	K	delete	15	15	15	15	15	15	15
67	D	delete	15	15	15	15	15	15	15
68	S	delete	15	15	15	15	15	15	15
69	T	delete	15	15	15	15	15	15	15
70	K	delete	15	15	15	15	15	15	15
71	W	delete	15	15	15	15	15	15	15
69	T	G	0	0	10	10	10	10	10
70	K	R	0	0	0	30	15	0	10
70	K	T	10	10	10	0	10	10	10
70	K	S	10	10	10	0	10	10	10
70	K	N	10	10	10	0	10	10	10
70	K	Q	10	10	10	0	10	10	10
151	Q	L	10	10	30	30	30	30	10
40	E	F	0	0	5	5	5	5	5
41	M	L	5	5	5	15	15	5	5
44	E	A	5	5	5	5	5	5	5
44	E	D	5	5	5	5	5	5	5
62	A	V	5	5	5	5	5	5	5
67	D	E	0	0	5	15	15	5	5
67	D	G	0	0	5	15	15	5	5
67	D	N	0	0	5	15	15	5	5
67	D	S	0	0	5	10	10	5	5
67	D	T	0	0	5	10	10	5	5
67	D	H	0	0	5	10	10	5	5
77	F	L	5	5	10	10	10	10	5
116	F	Y	5	5	10	10	10	10	5
118	V	I	0	0	5	5	5	5	5
210	L	W	5	5	5	15	15	5	5
215	T	C	0	0	10	20	20	10	5
215	T	D	0	0	10	20	20	10	5
215	T	E	0	0	10	20	20	10	5
215	T	I	0	0	10	20	20	10	5
215	T	V	0	0	10	20	20	10	5
215	T	S	0	0	10	20	20	10	5
215	T	N	0	0	5	20	20	5	5
215	T	A	0	0	5	20	20	5	5
215	T	L	0	0	5	20	20	5	5
219	K	E	0	0	5	10	10	5	5
219	K	N	0	0	5	10	10	5	5
219	K	Q	0	0	5	10	10	5	5
219	K	R	0	0	5	10	10	5	5
219	K	W	0	0	5	10	10	5	5
219	K	D	0	0	5	10	10	5	5
219	K	H	0	0	5	10	10	5	5
69	T	D	0	0	0	0	10	30	0
69	T	N	0	0	0	5	5	10	0
74	L	I	0	0	20	0	0	60	0
74	L	V	0	0	30	-10	0	60	0
75	V	A	0	0	0	0	15	15	0
75	V	I	5	5	0	0	10	10	0
75	V	M	0	0	0	0	60	30	0
75	V	T	0	0	0	0	60	30	0
75	V	S	0	0	0	0	20	10	0
333	G	D	0	0	0	0	0	0	0
333	G	E	0	0	0	0	0	0	0
348	N	I	0	0	0	10	10	0	0
184	M	I	60	60	15	-10	-10	10	-10
184	M	V	60	60	15	-10	-10	10	-10

There are 28 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.

Drug Name	Combination Rule	Score
ABC	(184VI AND 74VI)	20
ABC	(210W AND 215FY)	10
ABC	(210W AND 215SCDEIVNAL)	5
ABC	(41L AND 210W)	10
ABC	(41L AND 215FY)	10
ABC	(41L AND 215SCDEIVNAL)	5
AZT	(210W AND 215FY)	10
AZT	(210W AND 215SCDEIVNAL)	5
AZT	(41L AND 210W)	10
AZT	(41L AND 215FY)	10
AZT	(41L AND 215SCDEIVNAL)	5
D4T	(210W AND 215FY)	10
D4T	(210W AND 215SCDEIVNAL)	5
D4T	(41L AND 210W)	10
D4T	(41L AND 215FY)	10
D4T	(41L AND 215SCDEIVNAL)	5
DDI	(210W AND 215FY)	10
DDI	(210W AND 215SCDEIVNAL)	5
DDI	(41L AND 210W)	10
DDI	(41L AND 215FY)	10
DDI	(41L AND 215SCDEIVNAL)	5
TDF	(210W AND 215FY)	10
TDF	(210W AND 215SCDEIVNAL)	5
TDF	(41L AND 210W)	10
TDF	(41L AND 215FY)	10
TDF	(41L AND 215SCDEIVNAL)	5
TDF	(65R AND 115F)	10
TDF	(65R AND 151M)	10