Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NRTI Resistance Notes

Last updated on Feb 28, 2014
Position
 
ConsAA3TC
 
FTC
 
ABC
 
AZT
 
D4T
 
DDI
 
TDF
 
151QM15156060606015
215TY551545451515
215TF551545451515
69Tinsert30304545454545
70KR001030151010
151QL10103030303010
67Ddelete15153030303030
215TC00102020105
215TD00102020105
215TE00102020105
215TI00102020105
215TV00102020105
215TS00102020105
215TN00102020105
215TA00102020105
215TL00102020105
41ML551015151010
67DN005151555
210LW551015151010
67DE005101055
67DG005101055
67DS005101055
67DT005101055
67DH005101055
219KQ005101055
219KE005101055
219KN005101055
219KR005101055
219KW005101055
77FL55101010105
116FY55101010105
75VM0001040150
348NI000101000
40EF5555555
62AV5555555
75VI5555555
69TN00055100
44ED0000000
44EA0000000
118VI0000000
65KE00100101010
70KT1010100101010
70KS1010100101010
70KN1010100101010
70KQ1010100101010
74LI003000600
74LV003000600
115YF004500015
69Tdelete1515150151515
69TD000010300
69TG0010010105
75VT0010060300
75VS000010100
75VA000010100
75VL000010100
184MI606015-10-1010-10
184MV606015-10-1010-10
65KN151525-10252525
70KG101015-10151515
70KE101015-10151515
65KR303045-15456060

There are 74 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.
Drug NameCombination RuleScore
3TC118I+41L+215YF5
3TC40F+41L+215YF5
3TC44DA+118I10
3TC44DA+41L+215YF5
3TC67NG+70R+219QENR10
ABC118I+41L+215YF5
ABC184VI+74VI15
ABC210W+215FY10
ABC210W+215SCDEIVNAL5
ABC40F+41L+215YF5
ABC41L+210W10
ABC41L+215FY10
ABC41L+215SCDEIVNAL5
ABC44DA+118I10
ABC44DA+41L+215YF5
ABC67NG+70R+219QENR10
AZT118I+41L+215YF5
AZT151M+184VI10
AZT210W+215FY10
AZT210W+215SCDEIVNAL5
AZT40F+41L+215YF5
AZT41L+210W10
AZT41L+215FY10
AZT41L+215SCDEIVNAL5
AZT44DA+118I10
AZT44DA+41L+215YF5
AZT65R+151M25
AZT67NG+70R+219QENR10
D4T118I+41L+215YF5
D4T151M+184VI10
D4T210W+215FY10
D4T210W+215SCDEIVNAL5
D4T40F+41L+215YF5
D4T41L+210W10
D4T41L+215FY10
D4T41L+215SCDEIVNAL5
D4T44DA+118I10
D4T44DA+41L+215YF5
D4T65N+184VI10
D4T65R+184VI10
D4T67NG+70R+219QENR10
D4T70EGQ+184VI10
DDI118I+41L+215YF5
DDI210W+215FY10
DDI210W+215SCDEIVNAL5
DDI40F+41L+215YF5
DDI41L+210W10
DDI41L+215FY10
DDI41L+215SCDEIVNAL5
DDI44DA+118I10
DDI44DA+41L+215YF5
DDI67NG+70R+219QENR10
FTC118I+41L+215YF5
FTC40F+41L+215YF5
FTC44DA+118I10
FTC44DA+41L+215YF5
FTC67NG+70R+219QENR10
TDF115F+184VI10
TDF118I+41L+215YF5
TDF210W+215FY10
TDF210W+215SCDEIVNAL5
TDF40F+41L+215YF5
TDF41L+210W10
TDF41L+215FY10
TDF41L+215SCDEIVNAL5
TDF44DA+118I10
TDF44DA+41L+215YF5
TDF65N+184VI10
TDF65R+115F15
TDF65R+151M15
TDF65R+184VI10
TDF65R+62V10
TDF67NG+70R+219QENR10
TDF70EGQ+184VI10