Resistance Matrix

Resistance Mutation Comments

Resistance Mutation Scores

Drug Summaries

Position	Cons	AA	3TC	FTC	ABC	AZT	D4T	DDI	TDF
184	M	VI	60	60	15	-10	-10	10	-10
65	K	R	30	30	60	-15	45	60	60
66	K	insert	30	30	45	45	45	45	45
67	D	insert	30	30	45	45	45	45	45
68	S	insert	30	30	45	45	45	45	45
69	T	insert	30	30	45	45	45	45	45
70	K	insert	30	30	45	45	45	45	45
71	W	insert	30	30	45	45	45	45	45
65	K	N	15	15	15	-10	30	30	30
151	Q	M	15	15	60	60	60	60	15
66	K	delete	15	15	30	30	30	30	30
67	D	delete	15	15	30	30	30	30	30
68	S	delete	15	15	30	30	30	30	30
69	T	delete	15	15	15	0	15	15	15
70	K	delete	15	15	15	0	15	15	15
71	W	delete	15	15	15	0	15	15	15
70	K	GE	10	10	15	-10	15	15	15
70	K	TSNQ	10	10	10	0	10	10	10
151	Q	L	10	10	30	30	30	30	10
40	E	F	5	5	5	5	5	5	5
41	M	L	5	5	5	15	15	5	5
44	E	DA	5	5	5	5	5	5	5
62	A	V	5	5	5	5	5	5	5
75	V	I	5	5	5	5	5	5	5
77	F	L	5	5	5	5	5	5	5
116	F	Y	5	5	5	5	5	5	5
118	V	I	5	5	5	5	5	5	5
210	L	W	5	5	5	15	15	5	10
215	T	YF	5	5	15	45	45	15	15
67	D	EGSTH	0	0	5	10	10	5	5
67	D	N	0	0	5	15	15	5	5
69	T	D	0	0	0	0	10	30	0
69	T	N	0	0	0	5	5	10	0
69	T	G	0	0	10	0	10	10	5
70	K	R	0	0	5	30	15	5	10
74	L	IV	0	0	30	0	0	60	0
75	V	ALS	0	0	0	0	10	10	0
75	V	M	0	0	0	0	40	15	0
75	V	T	0	0	15	0	60	30	0
115	Y	F	0	0	45	0	0	0	15
215	T	CDEIVSNAL	0	0	10	20	20	10	10
219	K	QENRW	0	0	5	10	10	5	5
348	N	I	0	0	0	10	10	0	0

There are 62 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.

Drug Name	Combination Rule	Score
3TC	40F+41L+215FY	5
3TC	44AD+41L+215FY	5
3TC	V118I+41L+215FY	5
ABC	184VI+74VI	15
ABC	210W+215FY	10
ABC	210W+215SCDEIVNAL	5
ABC	40F+41L+215FY	5
ABC	41L+210W	10
ABC	41L+215FY	10
ABC	41L+215SCDEIVNAL	5
ABC	44AD+41L+215FY	5
ABC	67NG+70R+219QENR	10
ABC	V118I+41L+215FY	5
AZT	210W+215FY	10
AZT	210W+215SCDEIVNAL	5
AZT	40F+41L+215FY	5
AZT	41L+210W	10
AZT	41L+215FY	10
AZT	41L+215SCDEIVNAL	5
AZT	44AD+41L+215FY	5
AZT	65R+151M	15
AZT	67NG+70R+219QENR	10
AZT	V118I+41L+215FY	5
D4T	210W+215FY	10
D4T	210W+215SCDEIVNAL	5
D4T	40F+41L+215FY	5
D4T	41L+210W	10
D4T	41L+215FY	10
D4T	41L+215SCDEIVNAL	5
D4T	44AD+41L+215FY	5
D4T	65N+184VI	10
D4T	65R+184VI	10
D4T	67NG+70R+219QENR	10
D4T	70EG+184VI	10
D4T	V118I+41L+215FY	5
DDI	210W+215FY	10
DDI	210W+215SCDEIVNAL	5
DDI	40F+41L+215FY	5
DDI	41L+210W	10
DDI	41L+215FY	10
DDI	41L+215SCDEIVNAL	5
DDI	44AD+41L+215FY	5
DDI	67NG+70R+219QENR	10
DDI	V118I+41L+215FY	5
FTC	40F+41L+215FY	5
FTC	44AD+41L+215FY	5
FTC	V118I+41L+215FY	5
TDF	210W+215FY	10
TDF	210W+215SCDEIVNAL	5
TDF	40F+41L+215FY	5
TDF	41L+210W	10
TDF	41L+215FY	10
TDF	41L+215SCDEIVNAL	5
TDF	44AD+41L+215FY	5
TDF	65N+184VI	10
TDF	65R+115F	15
TDF	65R+151M	15
TDF	65R+184VI	10
TDF	65R+62V	10
TDF	67NG+70R+219QENR	10
TDF	70EG+184VI	10
TDF	V118I+41L+215FY	5