Resistance Matrix

Resistance Mutation Comments

Resistance Mutation Scores

Drug Summaries

Position	Cons	AA	EFV	NVP	ETR	RPV
90	V	I	0	0	0	0
98	A	G	5	15	5	5
100	L	I	45	45	30	30
100	L	V	30	15	10	15
101	K	E	15	30	10	30
101	K	P	60	60	45	60
101	K	Q	0	0	0	0
101	K	H	10	15	10	10
101	K	N	0	0	0	0
103	K	N	60	60	0	0
103	K	S	45	60	0	0
103	K	T	15	60	0	0
103	K	Q	0	0	0	0
103	K	E	0	0	0	0
103	K	H	60	60	0	0
103	K	R	0	0	0	0
106	V	A	30	60	0	0
106	V	M	60	60	0	0
106	V	I	0	0	0	0
108	V	I	5	10	0	0
138	E	A	0	0	5	5
138	E	K	10	10	10	30
138	E	Q	5	5	10	15
138	E	G	5	5	10	15
138	E	R	5	5	10	15
179	V	D	10	10	5	5
179	V	E	10	10	5	5
179	V	T	0	0	5	5
179	V	F	5	10	15	15
179	V	L	0	0	0	5
181	Y	C	30	60	30	30
181	Y	I	30	60	60	60
181	Y	V	30	60	60	60
181	Y	S	15	60	15	15
181	Y	F	15	60	15	15
181	Y	G	15	60	15	15
188	Y	C	60	60	0	0
188	Y	H	30	60	0	0
188	Y	L	60	60	15	60
188	Y	F	60	30	0	30
190	G	A	45	60	10	10
190	G	S	60	60	10	10
190	G	E	60	60	45	45
190	G	Q	60	60	45	45
190	G	C	60	60	10	10
190	G	V	60	60	10	10
190	G	T	60	60	10	10
221	H	Y	0	5	0	5
225	P	H	30	15	0	0
227	F	C	30	30	30	30
227	F	L	15	30	0	0
230	M	L	30	60	30	30
230	M	I	15	30	15	30
236	P	L	0	0	0	0
238	K	T	15	30	0	0
238	K	N	10	10	0	0
318	Y	F	10	30	0	0
348	N	I	10	15	0	0

There are 20 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.

Drug Name	Combination Rule	Score
EFV	103R+179D	20
EFV	103R+179E	5
EFV	106A+227L	15
EFV	106I+179D	5
ETR	106I+179D	5
ETR	106I+181C	5
ETR	181C+190ASCVT	10
ETR	181CIV+179F	15
ETR	90I+181C	5
NVP	103R+179D	20
NVP	103R+179E	5
NVP	106I+179D	5
RPV	101E+184I	30
RPV	106I+179D	5
RPV	106I+181C	5
RPV	138K+184I	30
RPV	181C+190ASCVT	10
RPV	181C+221Y	5
RPV	181CIV+179F	15
RPV	90I+181C	5