Resistance Matrix

Resistance Mutation Comments

Resistance Mutation Scores

Drug Summaries

Position	Cons	AA	EFV	NVP	ETR	RPV
90	V	I	0	0	5	5
98	A	G	5	15	5	5
98	A	S	0	0	0	0
100	L	I	30	30	15	15
101	K	E	15	30	10	10
101	K	P	30	60	30	60
101	K	Q	0	0	0	0
101	K	R	0	0	0	0
101	K	H	10	15	10	10
101	K	N	0	0	0	0
103	K	N	60	60	0	0
103	K	R	0	0	0	0
103	K	S	30	60	0	0
103	K	T	15	60	0	0
103	K	Q	0	0	0	0
103	K	E	0	0	0	0
103	K	H	60	60	0	0
106	V	A	30	60	0	0
106	V	M	60	60	0	0
106	V	I	0	0	0	0
108	V	I	5	10	0	0
138	E	A	5	5	5	5
138	E	K	10	10	10	30
138	E	Q	5	5	10	15
138	E	G	5	5	10	15
138	E	R	5	5	10	15
179	V	D	10	10	10	10
179	V	E	10	10	5	5
179	V	T	0	0	5	5
179	V	F	5	10	15	15
181	Y	C	30	60	30	30
181	Y	I	30	60	60	60
181	Y	V	30	60	60	60
181	Y	S	15	30	15	15
188	Y	C	15	60	0	0
188	Y	H	15	60	0	0
188	Y	L	60	60	10	60
190	G	A	40	60	10	10
190	G	S	60	60	10	10
190	G	E	60	60	15	15
190	G	Q	60	60	15	15
190	G	C	60	60	10	10
190	G	V	60	60	10	10
190	G	T	60	60	10	10
221	H	Y	5	5	5	5
225	P	H	30	15	0	0
227	F	C	30	30	30	30
227	F	L	0	15	0	0
230	M	L	30	60	30	30
236	P	L	0	0	0	0
238	K	T	15	30	0	0
238	K	N	0	10	0	0
238	K	R	0	0	0	0
318	Y	F	10	30	0	0
348	N	I	10	15	0	0

There are 9 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.

Drug Name	Combination Rule	Score
EFV	(103R AND 179D)	5
EFV	(106A AND 227L)	15
EFV	(106I AND 179D)	5
ETR	(181CIV AND 179F)	15
ETR	(181CIV AND 190ASEQCVT)	15
NVP	(103R AND 179D)	20
NVP	(106I AND 179D)	5
RPV	(181CIV AND 179F)	15
RPV	(181CIV AND 190ASEQCVT)	15