## INI Resistance Notes

Last updated on Feb 28, 2014

Resistance Matrix | Resistance Mutation Comments | Resistance Mutation Scores |

Position | Cons | AA | RAL | EVG | DTG |
---|---|---|---|---|---|

148 | Q | H | 60 | 60 | 20 |

148 | Q | K | 60 | 60 | 20 |

148 | Q | R | 60 | 60 | 20 |

151 | V | L | 30 | 60 | 15 |

263 | R | K | 15 | 30 | 15 |

51 | H | Y | 15 | 15 | 10 |

66 | T | K | 60 | 60 | 10 |

92 | E | Q | 30 | 60 | 10 |

118 | G | R | 30 | 30 | 10 |

138 | E | K | 15 | 15 | 10 |

138 | E | A | 15 | 15 | 10 |

140 | G | S | 30 | 30 | 10 |

140 | G | A | 30 | 30 | 10 |

140 | G | C | 30 | 30 | 10 |

153 | S | Y | 0 | 15 | 10 |

153 | S | F | 0 | 10 | 10 |

155 | N | H | 60 | 60 | 10 |

74 | L | M | 10 | 10 | 5 |

92 | E | V | 30 | 60 | 5 |

92 | E | G | 15 | 30 | 5 |

97 | T | A | 15 | 10 | 5 |

121 | F | Y | 30 | 30 | 5 |

66 | T | I | 15 | 60 | 0 |

66 | T | A | 15 | 60 | 0 |

68 | L | V | 0 | 0 | 0 |

95 | Q | K | 10 | 10 | 0 |

114 | H | Y | 0 | 0 | 0 |

128 | A | T | 0 | 0 | 0 |

138 | E | D | 0 | 0 | 0 |

143 | Y | C | 60 | 10 | 0 |

143 | Y | R | 60 | 10 | 0 |

143 | Y | H | 60 | 10 | 0 |

143 | Y | K | 60 | 10 | 0 |

143 | Y | S | 60 | 10 | 0 |

143 | Y | G | 60 | 10 | 0 |

143 | Y | A | 60 | 10 | 0 |

145 | P | S | 0 | 60 | 0 |

146 | Q | P | 0 | 60 | 0 |

147 | S | G | 0 | 60 | 0 |

151 | V | I | 0 | 0 | 0 |

151 | V | A | 15 | 30 | 0 |

155 | N | S | 30 | 30 | 0 |

155 | N | T | 30 | 30 | 0 |

157 | E | Q | 15 | 15 | 0 |

163 | G | R | 15 | 15 | 0 |

163 | G | K | 15 | 15 | 0 |

230 | S | R | 15 | 15 | 0 |

There are 9 combination rules below conditional on several mutations.

If triggered, their scores are added to the total score from the individual mutations above.

Drug Name | Combination Rule | Score |
---|---|---|

DTG | 148HRK+138AK | 25 |

DTG | 148HRK+140SAC | 25 |

DTG | 148HRK+163RK | 5 |

DTG | 148HRK+74M | 5 |

DTG | 148HRK+97A | 5 |

EVG | 143CRSGA+163R | 5 |

EVG | 143CRSGA+230R | 5 |

EVG | 143CRSGA+74MI | 5 |

EVG | 143CRSGA+97A | 5 |