Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.
Algorithm Name: Rega v9.1.0
Algorithm Version: 9.1.0

Gene Definitions
GeneDrug Classes
PR PI
RT NNRTI, NRTI
IN INI
FU EI


Level Definitions
OrderOriginalSir
1 Susceptible GSS 1 S
2 Susceptible GSS 1.5 S
3 Intermediate Resistant GSS 0.75 I
4 Intermediate Resistant GSS 0.5 I
5 Intermediate Resistant GSS 0.25 I
6 Resistant GSS 0 R


Drug Classes
NameDruglist
PI IDV/r,SQV/r,NFV,FPV/r,LPV/r,ATV/r,TPV/r,DRV/r
NRTI AZT,DDI,D4T,3TC,ABC,FTC,TDF
NNRTI NVP,EFV,ETR,RPV
INI RAL,EVG,DTG
EI T20


Drug
ConditionLevel/ Comment
AZT
SELECT ATLEAST 1 FROM (151M,69i) 6
SELECT ATLEAST 4 FROM (41L,67GN,69AN,70R,210W,215ACDEGHILNSVFY,219EHNQR) 6
(41L AND 210W AND 215Y AND EXCLUDE 184IV AND EXCLUDE 74V) 6
SELECT ATLEAST 3 FROM (67GN,70R,215F,219EQ) 6
SELECT ATLEAST 2 AND NOTMORETHAN 3 FROM (41L,67GN,69AN,70R,210W,215ACDEGHILNSVFY,219EHNQR) 4
(215ACDEGHILNSVFY AND EXCLUDE 184IV) 4
DDI
SELECT ATLEAST 1 FROM (69DGN,69i,151M) 6
(SELECT ATLEAST 1 FROM (65NR,74IV) AND 184IV) 6
SELECT ATLEAST 5 FROM (41L,67N,70R,74IV,210W,215ACDEGHILNSVFY,219EHNQR) 6
SELECT ATLEAST 1 FROM (65NR,70EG,74IV,75T) 4
(41L AND 215FY) 4
SELECT ATLEAST 3 AND NOTMORETHAN 4 FROM (41L,67N,70R,210W,215ACDEGHILNSVFY,219EHNQR) 4
D4T
SELECT ATLEAST 1 FROM (67d,69i,75AMST,151M) 6
SELECT ATLEAST 4 FROM (41L,67N,69ADGN,70R,210W,215ACDEGHILNSVFY,219EHNQR) 6
(41L AND 210W AND 215Y) 6
SELECT ATLEAST 2 AND NOTMORETHAN 3 FROM (41L,67N,69ADGN,70R,210W,215ACDEGHILNSVFY,219EHNQR) 4
(215ACDEGHILNSVFY AND EXCLUDE 184IV) 4
3TC
184VI 6
(65NR AND 151M) 6
SELECT ATLEAST 1 FROM (67d,69i,65NR,70EG) 4
SELECT ATLEAST 1 FROM (44AD,118I) AND SELECT ATLEAST 3 FROM (41L,67N,69AN,70R,210W,215ACDEGHILNSVFY,219QEHNR) 4
(SELECT ATLEAST 3 FROM (75I,77L,116Y) AND 151M) 4
ABC
SELECT ATLEAST 1 FROM (67d,69G) 6
SELECT ATLEAST 2 FROM (65NR,69i,74IV,115F,151M,184VI) 6
(SELECT ATLEAST 3 FROM (41L,67N,70R,210W,215ACDEGHILNSVFY,219QEHNR) AND 69i) 6
SELECT ATLEAST 1 FROM (65NR,74IV,115F,184VI) AND SELECT ATLEAST 4 FROM (41L,67N,70R,210W,215ACDEGHILNSVFY,219QEHNR) 6
(SELECT ATLEAST 2 FROM (75I,77L,116Y) AND 151M) 6
SELECT ATLEAST 1 AND NOTMORETHAN 1 FROM (69i,70EG,151M) 4
SELECT ATLEAST 1 FROM (65NR,74IV,115F,184IV) AND SELECT ATLEAST 2 AND NOTMORETHAN 3 FROM (41L,67N,70R,210W,215ACDEGHILNSVFY,219QEHNR) 4
SELECT ATLEAST 3 FROM (41L,67N,70R,210W,215ACDEGHILNSVYF,219QEHNR) 4
FTC
184VI 6
(65NR AND 151M) 6
SELECT ATLEAST 1 FROM (67d,69i,65NR,70EG) 4
SELECT ATLEAST 1 FROM (44AD,118I) AND SELECT ATLEAST 3 FROM (41L,67N,69AN,70R,210W,215ACDEGHILNSVFY,219QEHNR) 4
(SELECT ATLEAST 3 FROM (75I,77L,116Y) AND 151M) 4
TDF
69i 6
(65NR AND EXCLUDE 184IV) 6
SELECT ATLEAST 5 FROM (41L,67N,70R,210W,215ACDEGHILNSVYF,219EHNQR) 6
70EG 4
(65NR AND 184IV) 4
SELECT ATLEAST 3 FROM (41L,210W,215Y) 4
SELECT ATLEAST 4 FROM (41L,67N,70R,210W,215ACDEGHILNSVFY,219ENQHR) 4
(SELECT ATLEAST 3 FROM (75I,77L,116Y) AND 151M) 4
NVP
SCORE FROM ( 98G => 0.5, 100I => 2, MAX ( 101P => 2, 101EHNQ => 0.5 ), MAX ( 103HNST => 2, 103R => 0.5 ), MAX ( 106AM => 2, 106I => 0.5 ), 108I => 0.5, 138KQ => 1, 179DE => 0.5, 181CIV => 2, 188CHL => 2, 190ACEQSTV => 2, 221Y => 0.5, 227CL => 1, 230IL => 2, 238NT => 1, 318F => 1 ) (-INF TO 0.99 => 1, 1 TO 1.99 => 5, 2 TO INF => 6)
EFV
SCORE FROM ( 90I => 0.5, 98G => 0.5, 100I => 2, MAX ( 101P => 2, 101EHNQ => 0.5 ), MAX ( 103HNST => 2, 103R => 0.5 ), MAX ( 106M => 2, 106A => 1.5, 106I => 0.5 ), 108I => 0.5, MAX ( 138Q => 1.5, 138K => 0.5 ), 179DE => 0.5, 181CIV => 2, 188CHFL => 2, 190ACEQSTV => 2, 221Y => 0.5, 225H => 1.5, 227CL => 0.5, 230IL => 2, 238NT => 0.5, 318F => 0.5 ) (-INF TO 0.99 => 1, 1 TO 1.99 => 5, 2 TO INF => 6)
ETR
SCORE FROM ( 90I => 0.25, 98G => 0.25, 100I => 1.5, MAX ( 101P => 1.5, 101EHNQ => 0.5, 101R => 0.25 ), 103HNST => 0.25, MAX ( 106I => 0.5, 106AM => 0.25 ), 108I => 0.25, MAX ( 138KQ => 0.75, 138A => 0.5 ), MAX ( 179F => 0.75, 179DET => 0.25 ), 181CIV => 1.5, 188CHFL => 0.25, MAX ( 190CEQSTV => 0.75, 190A => 0.5 ), 221Y => 0.25, 225H => 0.25, MAX ( 227C => 1.5, 227L => 0.25 ), 230IL => 1.5, 234I => 0.25, 236L => 0.25, 238NT => 0.25, 318F => 0.25 ) (-INF TO 1.49 => 1, 1.5 TO 2.99 => 4, 3 TO INF => 6)
RPV
SCORE FROM ( 90I => 0.5, MAX(101E => 1.5, 101P => 2.5, 101QT => 0.5, (101E AND 184IV) => 2.5), 103S => 0.5, 106AI => 0.5, 108I => 0.5, MAX(138AGKQRS => 1.5, (138K AND 184IV) => 2.5), MAX(179DTI => 0.5, 179L => 1.5), MAX(181C => 1.5, 181IV => 2.5), 188L => 2.5, 189I => 0.5, 190E => 0.5, 221Y => 1.5, 227C => 1.5, 230IL => 1.5, (100I AND 103N) => 2.5) (-INF TO 1.49 => 1, 1.5 TO 2.49 => 5, 2.5 TO INF => 6)
IDV/r
SELECT ATLEAST 0 FROM (1P) 2
SCORE FROM ( MAX ( 10F => 1, 10IV => 0.25 ), MAX ( 20T => 0.5, 20IMRV => 0.25 ), 24I => 1, 32I => 1, 35GN => 0.25, MAX ( 43T => 0.5, 43R => 0.25 ), 46IL => 1.5, MAX ( 48MV => 1, 48A => 0.5 ), 50L => -0.25, MAX ( 54AST => 1.5, 54V => 1, 54LM => 0.5 ), 62V => 0.25, 66F => 0.5, MAX ( 71I => 0.5, 71TV => 0.25 ), 73STC => 0.5, MAX ( 74P => 0.5, 74AS => 0.25 ), 76V => 1, MAX ( 82AFST => 2, 82M => 1 ), MAX ( 84AV => 2, 84C => 0.5 ), MAX ( 88S => 1, 88D => 0.5 ), MAX ( 89TV => 0.5, 89I => 0.25 ), 90M => 1, 95F => 0.5 ) (-INF TO 1.99 => 2, 2 TO 2.99 => 3, 3 TO INF => 6)
SQV/r
SELECT ATLEAST 0 FROM (1P) 2
SCORE FROM ( MAX ( 10F => 0.5, 10IV => 0.25 ), 11I => 0.25, MAX ( 20T => 0.5, 20IMRV => 0.25 ), 24I => 1, 46IL => 0.5, MAX ( 48MV => 2, 48A => 0.5 ), MAX ( 50V => 0.5, 50L => -0.25 ), 53L => 1, MAX ( 54AST => 1.5, 54V => 1, 54LM => 0.5 ), 58E => 0.5, 62V => 0.25, MAX ( 71V => 1, 71I => 0.5, 71T => 0.25 ), 73STC => 0.5, MAX ( 74SP => 0.5, 74A => 0.25 ), 82AFLMST => 0.25, MAX ( 84AC => 1.5, 84V => 1 ), 88DS => 1, MAX ( 89V => 1, 89T => 0.5, 89I => 0.25 ), 90M => 2 ) (-INF TO 1.99 => 2, 2 TO 3.49 => 3, 3.5 TO INF => 6)
NFV
SCORE FROM ( MAX ( 10F => 0.5, 10IV => 0.25 ), MAX ( 20T => 0.5, 20IMRV => 0.25 ), 23I => 0.5, 24I => 0.5, 30N => 2, 32I => 0.5, 33FI => 0.25, 35GN => 0.25, MAX ( 43T => 0.5, 43R => 0.25 ), 46IL => 0.5, 48AV => 0.5, 50L => -0.25, MAX ( 54AST => 1.5, 54V => 1, 54LM => 0.5 ), 58E => 0.5, 62V => 0.25, 64V => 0.25, 66F => 0.5, MAX ( 71I => 0.5, 71TV => 0.25 ), 73STC => 0.5, MAX ( 74P => 0.5, 74AS => 0.25 ), 76V => 0.5, MAX ( 82ATF => 1, 82LMS => 0.5 ), MAX ( 84AC => 1.5, 84V => 0.5 ), MAX ( 88S => 1.5, 88D => 1 ), MAX ( 89TV => 0.5, 89I => 0.25 ), 90M => 2, 93M => 0.5 ) (-INF TO 1.24 => 1, 1.25 TO 1.99 => 4, 2 TO INF => 6)
FPV/r
SELECT ATLEAST 0 FROM (1P) 2
SCORE FROM ( MAX ( 10F => 0.5, 10IV => 0.25 ), MAX ( 20T => 0.5, 20IRMV => 0.25 ), 24I => 0.5, 32I => 0.5, MAX ( 33F => 0.5, 33I => 0.25 ), MAX ( 43T => 0.5, 43R => 0.25 ), 46IL => 0.5, 47AV => 1, MAX ( 48M => 1, 48A => 0.5, 48V => 0.25 ), MAX ( 50V => 2, 50L => -0.25 ), MAX ( 54MTV => 1, 54AL => 0.5 ), 58E => 0.5, 76V => 1.5, MAX ( 82F => 1, 82AMST => 0.5 ), 84ACV => 1.5, 88S => -0.25, MAX ( 89TV => 0.5, 89I => 0.25 ), 90M => 0.25 ) (-INF TO 1.99 => 2, 2 TO 3.49 => 3, 3.5 TO INF => 6)
LPV/r
SELECT ATLEAST 0 FROM (1P) 2
SCORE FROM ( MAX ( 10F => 0.5, 10IV => 0.25 ), MAX ( 20T => 0.5, 20IMRV => 0.25 ), 24FI => 0.5, MAX ( 32i => 1.5, 32I => 0.5 ), MAX ( 33F => 0.5, 33I => 0.25 ), MAX ( 43T => 0.5, 43R => 0.25 ), 46IL => 0.5, MAX ( 47A => 2, 47V => 1 ), MAX ( 48M => 1, 48AV => 0.5 ), MAX ( 50V => 1.5, 50L => -0.25 ), 53L => 0.5, MAX ( 54AT => 1.5, 54SV => 1, 54LM => 0.5 ), 64MV => 0.25, MAX ( 71I => 0.5, 71TV => 0.25 ), 73STC => 0.5, 76V => 1.5, 77ATV => 0.25, MAX ( 82FS => 1, 82ALMT => 0.5 ), MAX ( 84A => 1, 84V => 0.5 ), 88D => 0.5, 90M => 0.5 ) (-INF TO 1.99 => 2, 2 TO 3.49 => 3, 3.5 TO INF => 6)
ATV/r
SELECT ATLEAST 0 FROM (1P) 2
SCORE FROM ( MAX ( 10Y => 1, 10F => 0.5, 10IV => 0.25 ), MAX ( 20T => 1, 20IMRV => 0.25 ), 24I => 0.5, 32I => 0.5, 33FI => 0.25, 46IL => 0.5, 47V => 1, 48MV => 2, 50L => 2, MAX ( 54AST => 1.5, 54V => 1, 54LM => 0.5 ), 58E => 0.5, MAX ( 71IL => 0.5, 71TV => 0.25 ), 73ACFST => 0.5, MAX ( 74P => 1, 74AS => 0.25 ), 76V => -0.25, MAX ( 82LT => 1, 82AMSF => 0.5 ), 84V => 1, 85V => 0.5, MAX ( 88S => 1.5, 88D => 1 ), 90M => 1 ) (-INF TO 1.99 => 2, 2 TO 3.49 => 3, 3.5 TO INF => 6)
TPV/r
SELECT ATLEAST 0 FROM (1P) 2
SCORE FROM ( 11L => 0.25, 32I => 0.25, 33F => 0.5, 38W => 0.25, 41T => 1, 43T => 1, 45I => 0.25, 46L => 0.5, MAX ( 47V => 2, 47A => 0.5 ), 50L => -0.25, MAX ( 54AMV => 1, 54ST => 0.5 ), 58E => 1.5, 71L => 0.25, 73T => 0.25, 74P => 2, MAX ( 82T => 2, 82LS => 1.5, 82AFM => 0.25 ), 83D => 1.5, 84ACV => 1, 89TV => 0.25, 90M => 0.25 ) (-INF TO 1.99 => 2, 2 TO 3.49 => 3, 3.5 TO INF => 6)
DRV/r
SELECT ATLEAST 0 FROM (1P) 2
SCORE FROM ( 11I => 1, MAX ( 32I => 1, 32L => 0.5 ), MAX ( 33F => 1, 33MV => 0.5, 33I => 0.25 ), 34V => 0.5, MAX ( 35G => 0.5, 35N => 0.25 ), MAX ( 41T => 1, 41I => 0.5 ), 46IL => 0.5, 47AV => 1, 48M => 0.5, MAX ( 50V => 1.5, 50L => -0.25 ), MAX ( 54M => 1.5, 54L => 1, 54STV => 0.5 ), 70E => 1, 73ACFSTV => 0.5, MAX ( 74P => 1, 74E => 0.5 ), 76V => 1.5, 82FL => 0.5, 84ACV => 1.5, 85V => 0.5, 88S => -0.25, MAX ( 89V => 1, 89T => 0.5, 89I => 0.25 ) ) (-INF TO 1.99 => 2, 2 TO 3.49 => 3, 3.5 TO INF => 6)
T20
SELECT ATLEAST 2 FROM (36DESV,38AEM,40H,41R,42DEHKQT,43DKQS,44MV,45MPQ) 6
SELECT ATLEAST 1 AND NOTMORETHAN 1 FROM (36DESV,38AEM,40H,41R,42DEHKQT,43DKQS,44MV,45MPQ) 5
EVG
SCORE FROM ( 51Y => 0.5, 66AIK => 2, 92QG => 2, 97A => 0.5, 114Y => 0.5, 121Y => 1, 140SAC => 1, 145S => 2, MAX(146ILPR => 2.0, 146K => 0.5), 147G => 2, 148HKR => 2, 153FY => 0.5, 155HST => 2, 263K => 0.5) (-INF TO 0.99 => 1, 1 TO 1.99 => 5, 2 TO INF => 6)
DTG
SCORE FROM ( 51Y => 0.5, 74M => 0.5, 92Q => 0.5, 97A => 0.5, 118R => 1.5, 124A => 0.5, 138K => 0.5, 140ACS => 0.5, 143CHR => 0.5, 148HKR => 1, 153F => 0.5, 155H => 0.5, 263K => 1.5) (-INF TO 1.49 => 1, 1.5 TO 1.99 => 4, 2 TO INF => 6)
RAL
SCORE FROM ( 74M => 1, 92Q => 1, 97A => 0.25, MAX(138A => 1.0, 138K => 0.25), 140AS => 1, MAX(143CH => 1.0, 143R => 20.0), 148HKR => 20, 151I => 0.25, 155HS => 20, 156N => 0.25, MAX(163K => 1.0, 163R => 0.25), 206S => 0.25, 230N => 0.25, 232N => 1) (-INF TO 0.99 => 1, 1 TO 19.99 => 5, 20 TO INF => 6)