Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.
Algorithm Name: ANRS
Algorithm Version: 2012.09

Gene Definitions
GeneDrug Classes
PR PI
RT NNRTI, NRTI
IN INI
FU EI


Level Definitions
OrderOriginalSir
1 Susceptible S
2 Possible resistance I
3 Resistance R


Drug Classes
NameDruglist
PI IDV/r,SQV/r,NFV,FPV/r,LPV/r,ATV/r,TPV/r,DRV/r
NRTI AZT,D4T,DDI,3TC,FTC,ABC,TDF
NNRTI NVP,EFV,ETR,RPV
EI T20
INI RAL,EVG,DTG


Drug
ConditionLevel/ Comment
AZT
215YF 3
SELECT ATLEAST 3 FROM (41L,67N,70R,210W,215ACDEGHILNSV,219QE) 3
151M 3
69i 3
215ACDEGHILNSV 2
D4T
75MSAT 3
215YF 3
SELECT ATLEAST 3 FROM (41L,67N,70R,210W,215ACDEGHILNSV,219QE) 3
65R 3
151M 3
69i 3
215ACDEGHILNSV 2
DDI
EXCLUDE 70R AND EXCLUDE 184VI AND SELECT ATLEAST 2 FROM (41L,69D,215FY,219QE) 3
SELECT ATLEAST 1 AND NOTMORETHAN 1 FROM (70R,184VI) AND SELECT ATLEAST 3 FROM (41L,69D,215FY,219QE) 3
70R AND 184VI AND SELECT ATLEAST 4 FROM (41L,69D,215FY,219QE) 3
151M 3
69i 3
74VI 3
65R 2
3TC
184VI 3
69i 3
65R 2
151M 2
FTC
184VI 3
69i 3
65R 2
151M 2
ABC
SELECT ATLEAST 4 FROM (41L,67N,74VI,184VI,210W,215YF) 3
74VI 3
151M 3
69i 3
65R 3
115F 3
SELECT ATLEAST 3 AND NOTMORETHAN 3 FROM (41L,67N,184VI,210W,215YF) 2
TDF
SELECT ATLEAST 6 FROM (41L,44D,67N,69DNS,74VI,210W,215YF) 3
65R 3
69i 3
70E 3
SELECT ATLEAST 3 AND NOTMORETHAN 5 FROM (41L,44D,67N,69DNS,74VI,210W,215YF) 2
EFV
100I 3
101E 3
103HNST 3
106M 3
138K 3
181CI 3
188CL 3
190ACEQSTV 3
225H 3
230L 3
NVP
98S 3
100I 3
101E 3
103HNST 3
106AM 3
181CI 3
188CHL 3
190ACEQSTV 3
230L 3
138K 2
ETR
SELECT ATLEAST 4 FROM (90I,98G,100I,101EHIPR,106I,179DFILMT,181CI,190AS,230L) 3
138K 3
181V 3
181C AND 221Y 3
SELECT ATLEAST 3 AND NOTMORETHAN 3 FROM (90I,98G,100I,101EHIPR,106I,179DFILMT,181CI,190AS,230L) 2
138AGQR 2
RPV
101EP 3
138AGKQRS 3
179L 3
181CIV 3
188L 3
221Y 3
230ILV 3
100I AND 103N 3
IDV/r
46IL 3
82ATFSM 3
84AV 3
90M AND SELECT ATLEAST 2 FROM (20MR,24I,32I,36I,54VLMT,71VT,73SA,77I) 3
90M 2
SQV/r
48V 3
SELECT ATLEAST 4 FROM (10FIMRV,15AV,20IMRT,24I,62V,73ST,82AFTS,84V,90M) 3
SELECT ATLEAST 3 AND NOTMORETHAN 3 FROM (10FIMRV,15AV,20IMRT,24I,62V,73ST,82AFTS,84V,90M) 2
NFV
30N 3
84AV 3
88SD 3
90M 3
82ATFS AND SELECT ATLEAST 2 FROM (10I,36I,46IL,54VLMT,71VT,77I) 2
FPV/r
50V 3
SELECT ATLEAST 4 FROM (10IFV,33F,36I,54ALMSTV,62V,82ACFG,84V,90M) 3
32I AND 47AV 3
LPV/r
SELECT ATLEAST 6 FROM (10FIRV,20MR,24I,33F,46IL,50V,53L,54MLTV,63P,71ILTV,82AFST,84V,90M) 3
47A 3
76V 3
SELECT ATLEAST 4 AND NOTMORETHAN 5 FROM (10FIRV,20MR,24I,33F,46IL,50V,53L,54MLTV,63P,71ILTV,82AFST,84V,90M) 2
ATV/r
50L 3
88S 3
SELECT ATLEAST 3 FROM (10FIV,16E,33FIV,46IL,60E,84V,85V,90M) 3
TPV/r
53LWY AND SELECT ATLEAST 4 FROM (36ILV, 58E, 69IKNQRY, 89IMRTV) 3
EXCLUDE 53LWY AND SELECT ATLEAST 3 FROM (36ILV, 58E, 69IKNQRY, 89IMRTV) 3
53LWY AND SELECT ATLEAST 3 FROM (36ILV, 58E, 69IKNQRY, 89IMRTV) 2
EXCLUDE 53LWY AND SELECT ATLEAST 2 FROM (36ILV, 58E, 69IKNQRY, 89IMRTV) 2
DRV/r
SELECT ATLEAST 4 FROM (11I,32I,33F,47V,50V,54LM,74P,76V,84V,89V) 3
SELECT ATLEAST 3 AND NOTMORETHAN 3 FROM (11I,32I,33F,47V,50V,54LM,74P,76V,84V,89V) 2
T20
36ADESV 3
38AEKM 3
40HKPT 3
42DT 3
43DHKS 3
44M 3
45QM 3
RAL
66K 3
E92Q 3
118R 3
121Y 3
140AS 3
143CGHRS 3
Q148EHGKR 3
151L 3
N155HST 3
E157Q 3
EVG
66IAK 3
E92Q 3
121Y 3
E138K 3
G140CS 3
145S 3
S147G 3
Q148HKR 3
151L 3
N155HST 3
E157Q 3
DTG
118R 3
151L 3
153Y 3
66K AND 74M 3
92Q AND 155H 3
138AK AND 148HKR 3
140CS AND 148HKR 3
148R AND 155H 3
66K 2
153F 2

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