Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NRTI Scores Comparisons

Last updated on March 12, 2014 (ver 6.3.1 vs 7.0)
Individual Mutations
3TCFTCABCAZTD4TDDITDF
184VI606015-10-1010-10
41L555 => 1015155 => 105 => 10
67EGSTH  5101055
67N  5151555
70R  5 => 1030155 => 1010
210W555 => 1015155 => 1010
215YF551545451515
219QENRW  5101055
        
40F5555555
44DA5 => 05 => 05 => 05 => 05 => 05 => 05 => 0
118I5 => 05 => 05 => 05 => 05 => 05 => 05 => 0
        
215CDEIVSNAL  1020201010 => 5
        
65R303060 => 45-15456060
65N151515 => 25-1030 => 2530 => 2530 => 25
65E0 => 100 => 100 => 100 => 10
70GE101015-10151515
70TSNQ101010 101010
74IV  30  60 
115F  45   15
        
62V5555555
75I5555555
77L555 => 105 => 105 => 105 => 105
116Y555 => 105 => 105 => 105 => 105
151L10103030303010
151M15156060606015
        
69i30304545454545
67d15153030303030
69d151515 151515
        
69D    1030 
69N   5510 
69G  10 10105
75ALS    1010 
75M   0 => 104015 
75T  15 => 10 6030 
348I   1010  

                       
Combination of Mutations
RuleAZTD4TTDFABCDDI3TCFTC 
210W+215FY1010101010  
41L+210W1010101010  
41L+215FY1010101010  
        
40F+41L+215YF5555555
44DA+41L+215YF5555555
118I+41L+215YF5555555
44DA+118I0 => 100 => 100 => 100 => 100 => 100 => 100 => 10
        
41L+215SCDEIVNAL55555  
210W+215SCDEIVNAL55555  
        
67NG+70R+219QENR10101010101010
        
184VI+74VI   15   
65R+151M15 => 25 15    
65R+115F  15    
65R+62V  10    
115F+184VI  0 => 10    
65RN+184VI 1010    
70Q+184VI 0 => 100 => 10    
70EG+184VI 1010    
151M+184VI0 => 100 => 10     

To further the transparency of these changes, we have included a spreadsheet with (i) unique mutation patterns from >40,000 HIV-1 sequences, (ii) calculated estimate of susceptibility to each ARV of a class, (iii) the changes from the previous version of the algorithm to the current version. The NRTI spreadsheet has 2,221 unique patterns of scored mutations.

The spreadsheet has two worksheets:

  1. "Score Changes By Drug" shows only the patterns where there is a difference in score; for example, in the NNRTI spreadsheet, Rilpivirine (RPV) shows 231 rows indicating that the score of 641 drug resistance mutation patterns were left unchanged. More importantly, each row shows a mutation pattern with details on what the difference in scores is and what caused it; for example the first RPV row in the worksheet (shown below) shows the drug resistance mutation pattern "179D" a) occuring 562 times in our database, b) scoring 10 points, putting it in the second lowest resistance category, "Potential low-level resistance (2)", a one level increase from "Susceptible (1)" with a score of 5, and c) changing in levels because mutation 179D now scores 10 points.
    DRMPatternCountDrugOld version levelNew version levelLevel differenceOld version scoreNew version scoreNew Scores
    179D562RPV121510V179D(10)

  2. "Mutation Patterns" in the other hand shows all patterns in decreasing order of frequency with old (prefix 'o') and new (prefix 'n') drug intepretation levels.