Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Scores Comparisons

Last updated on March 12, 2014 (ver 6.3.1 vs 7.0)
Individual Mutations
 EFVNVPETRRPV
98G5 => 1015 => 305 => 105 => 15
100I45453030 => 60
100V3015 => 301015
101E153010 => 1530
101P60604560
101H10 => 15151010
103N6060  
103S4560  
103T1560  
103H6060  
106A30 => 4560  
106M6060  
108I5 => 1010 => 15  
138A  5 => 1015
138K10101030
138Q5 => 105 => 101015
138G5 => 105 => 101015
138R5 => 105 => 101015
179D10105 => 105 => 10
179E10105 => 105 => 10
179T0 => 100 => 105 => 105 => 10
179L0 => 100 => 100 => 105 => 15
179F5 => 1010 => 151515
181C30603030
181I30606060
181V30606060
181S15601515
181F156015 => 3015 => 30
181G156015 => 3015 => 30
188C6060  
188H3060  
188L60601560
188F6030 30
190A456010 => 1510 => 15
190S606010 => 1510 => 15
190E60604545
190Q60604545
190C60601010
190V60601010
190T60601010
221Y0 => 105 => 100 => 105 => 10
225H3015 => 30  
227C30303030
227L1530  
230L30 => 45603030 => 45
230I15301530
238T15 => 3030 => 60  
238N1010  
318F1030  
348I1015  

Combination of Mutations
RuleNVPEFVETRRPV
103R+179D20200 => 15
103R+179E5 => 205 => 20
106A+227L15
106I+179D5 => 05 => 05 => 05 => 0
106I+181C5 => 05 => 0
90I+181C5 => 05 => 0
181C+179F1515
181IV+179F15 => 015 => 0
181C+190ASCVT1010
181C+221Y5 => 0
101E+184I30 => 20
138K+184I30

To further the transparency of these changes, we have included a spreadsheet with (i) unique mutation patterns from >40,000 HIV-1 sequences, (ii) calculated estimate of susceptibility to each ARV of a class, (iii) the changes from the previous version of the algorithm to the current version. The NNRTI spreadsheet has 872 unique patterns of scored mutations.

The spreadsheet has two worksheets:

  1. "Score Changes By Drug" shows only the patterns where there is a difference in score; for example, in the NNRTI spreadsheet, Rilpivirine (RPV) shows 231 rows indicating that the score of 641 drug resistance mutation patterns were left unchanged. More importantly, each row shows a mutation pattern with details on what the difference in scores is and what caused it; for example the first RPV row in the worksheet (shown below) shows the drug resistance mutation pattern "179D" a) occuring 562 times in our database, b) scoring 10 points, putting it in the second lowest resistance category, "Potential low-level resistance (2)", a one level increase from "Susceptible (1)" with a score of 5, and c) changing in levels because mutation 179D now scores 10 points.
    DRMPatternCountDrugOld version levelNew version levelLevel differenceOld version scoreNew version scoreNew Scores
    179D562RPV121510V179D(10)

  2. "Mutation Patterns" in the other hand shows all patterns in decreasing order of frequency with old (prefix 'o') and new (prefix 'n') drug intepretation levels.