Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

INI Scores Comparisons

Last updated on March 12, 2014 (ver 6.3.1 vs 7.0)
Individual Mutations
RALEVGDTG
51Y151510
66I10 => 1560 
66A1560 
66K606010
74M10105
92Q306010
92V30605
92G153010 => 5
95K5 => 105 => 10 
97A10 => 15105
114Y 5 => 0 
118R0 => 300 => 300 => 10
121Y30305
128T 5 => 0 
138K151510
138A151510
140S303010
140A303010
140C303010
143C600 => 10 
143R600 => 10 
143H45 => 600 => 10 
143K45 => 600 => 10 
143SGA0 => 600 => 10 
145S 60 
146P 30 => 60 
147G 60 
148H606020
148R606020
148K606030 => 20
151I5 => 05 => 0 
151A1530 
151L306015
153Y 1510
153F 1010
155H606010
155S3030 
155T3030 
157Q10 => 1510 => 15 
163R10 => 1510 => 15 
163K10 => 1510 => 15 
230R10 => 1510 => 15 
263K10 => 1520 => 3010 => 15

Combination of Mutations
RuleDTGEVG
148HRK+140SAC20 => 25 
148HRK+138AK20 => 25 
148HRK+74M5 
148HRK+97A5 
148HRK+163RK5 
143CRSGA+97A 0 => 5
143CRSGA+74MI 0 => 5
143CRSGA+163R 0 => 5
143CRSGA+230R 0 => 5

To further the transparency of these changes, we have included a spreadsheet with (i) unique mutation patterns from >40,000 HIV-1 sequences, (ii) calculated estimate of susceptibility to each ARV of a class, (iii) the changes from the previous version of the algorithm to the current version. The INI spreadsheet has 123 unique patterns of scored mutations.

The spreadsheet has two worksheets:

  1. "Score Changes By Drug" shows only the patterns where there is a difference in score; for example, in the NNRTI spreadsheet, Rilpivirine (RPV) shows 231 rows indicating that the score of 641 drug resistance mutation patterns were left unchanged. More importantly, each row shows a mutation pattern with details on what the difference in scores is and what caused it; for example the first RPV row in the worksheet (shown below) shows the drug resistance mutation pattern "179D" a) occuring 562 times in our database, b) scoring 10 points, putting it in the second lowest resistance category, "Potential low-level resistance (2)", a one level increase from "Susceptible (1)" with a score of 5, and c) changing in levels because mutation 179D now scores 10 points.
    DRMPatternCountDrugOld version levelNew version levelLevel differenceOld version scoreNew version scoreNew Scores
    179D562RPV121510V179D(10)

  2. "Mutation Patterns" in the other hand shows all patterns in decreasing order of frequency with old (prefix 'o') and new (prefix 'n') drug intepretation levels.