HIV Drug Resistance Database

NNRTI Mutation Pattern & Susceptibility

243 patterns of major drug resistance mutations (defined here) from 38674 clinical isolates obtained from 34364 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2009-9-16). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Antimicrobial Agents and Chemotherapy, Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation Patterns	Number of Sequences	NVP fold_n	DLV fold_n	EFV fold_n
None	27306	0.7₄₁₂	0.7₄₀₃	0.6₃₉₈
103N	3756	51₇₅	31₇₃	22₇₄
103N,181C	1002	400₂₆	250₂₆	31₂₇
181C	933	148₃₉	35₃₉	1.3₃₉
100I,103N	676	69₂₅	200₂₁	680₂₅
188L	520	400₁₁	4.3₁₁	66₁₁
181C,190A	484	300₅	22₅	42₅
190A	393	85₁₇	0.3₁₇	6.5₁₇
103N,181C,190A	334	400₂	250₂	700₂
101E,181C,190A	280	400₇	23₇	105₇
103N,190A	273	500₁	37₁	213₁
101E,190A	182	590₄	4.0₄	197₄
101E	128	8.9₂	4.0₂	4.3₂
190S	123	196₁₀	0.4₈	80₁₀
106A	106	400₉	5.0₉	8.0₉
103S,190A	99	218₃	2.0₂	85₃
101P,103N	96	400₃	200₃	700₃
101E,190S	89	506₄	1.8₄	500₃
103N,188L	87	590₂	345₂	385₂
103N,230L	79	600₅	225₄	315₅
181I	71	400₄	21₄	0.8₄
181C,190S	65	300₁	12₁	400₁
101E,181C	64	400₁	250₁	4.0₁
101E,181C,190S	61
103N,106A	60	540₂	32₂	292₂
103N,106M	54
190E	52	600₅	5.6₅	700₅
106A,190A	52	417₁	0.9₁	13₁
106M	50	67₂	11₂	356₂
103N,188C	41
181V	40	400₁	152₁	3.9₁
190Q	39	500₄	8.1₄	533₄
101E,103N,190A	37
101E,103N	32
101P,190A	31
188C	28	216₂	58₂	352₂
230L	27	25₂	36₂	14₂
181C,188L	26
103N,190S	26
188L,190A	25
101P,103S	24	350₂	225₂	500₂
188H	23	3.6₁	12₁	7.3₁
103N,188H	23	378₂	250₁	493₂
103N,181I	23
236L	22	2.0₁	53₁	1.0₁
100I,188L	21
106M,190A	20
103S	20	5.0₁	10.0₁	2.4₁
101E,188L	19
101E,103N,181C,190A	19
103N,106A,181C	18
106A,181C	18
101P	16	303₂	36₂	34₂
103N,181C,188C	15
103T	15
106A,181C,190A	13
103S,181C,190A	13
103H,181C,190A	13
101P,188L	12
103N,179F,181C	12
190C	12	285₂	0.1₂	435₂
100I,103N,181C	11
100I,103N,190A	10
181C,230L	10	690₂	206₂	15₂
103N,106A,190A	9
101E,181I	9
100I	9	3.1₁	30₁	10.0₁
103N,179F,181C,190A	9
100I,103N,181C,190A	9
101E,103N,181C	9
106M,188C	8
103N,106A,181C,190A	8
101E,190C	8
103N,181C,190S	8
103S,181C	8
103N,106M,181C	8
103N,181V	7
106M,181C,190A	7
103N,236L	7	165₁	190₁	5.0₁
100I,103N,181I	7
101E,188L,190A	6
101E,181I,190A	6
101E,106M,190A	6
181C,188L,190A	6	300₁	120₁	400₁
101E,190V	6
106M,188L	6
100I,103N,188H	5
103N,181C,230L	5
103N,181C,188L	5
100I,103S	5
181C,188C	5
101E,181V	5
101E,106M	5
101P,181C	5
101E,179F,181C,190A	4
106M,181C	4
181I,190A	4
179F,181C,190A	4
181C,236L	4
103N,188C,190A	4
106M,230L	4
103N,106M,181C,190A	4
101E,188C	4
101P,103N,190A	4
100I,230L	4
101E,181V,190A	4	400₁	250₁	700₁
100I,103N,230L	3
103S,106M	3
179F,181C,190S	3
103N,106M,188C	3
103N,181I,190A	3
190V	3	600₂	0.1₂	270₂
101E,106A,190A	3
103N,181V,190A	3
101E,106A,181C,190A	3
103N,190E	3
101P,190S	3
190A,230L	3
101E,181I,188L,190A	3
179F,181C	2	400₁	200₁	21₁
100I,181I	2
101E,106M,181V,190A	2
103T,236L	2
103N,181C,188H	2
101E,181I,190S	2
103T,106A	2
103T,181C	2
103T,230L	2
100I,101E,190A	2
101E,181C,230L	2
181C,190C	2
100I,181I,190A	2
190T	2	356₁	0.1₁	150₁
100I,103N,106M	2
106A,190S	2
101E,103N,106A	2
100I,103N,188C	2
181V,190A	2
103S,190S	2
101E,103N,106A,181C,190A	2
100I,103N,188L	2
103S,188H,190A	2	800₁	7.4₁	800₁
100I,181C	2
106M,188H	2
101E,188H,190A	2
103N,188L,230L	2
106A,230L	2

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

The Team

The Data